Brain extracts that promote the proliferation of neuroblasts from chick embryo in culture.

abstract：:A study of complex I (NADH:ubiquinone oxidoreductase) activity in Parkinson's disease (PD) brain has identified loss of activity only in substantia nigra although loss of activity of this enzyme has been identified in a number of non-brain tissues. We investigated this paradox by studying complex I and other complexes...

journal_title：Brain research

authors： Parker WD Jr,Parks JK,Swerdlow RH

更新日期：2008-01-16 00:00:00

abstract：:Perfusion of hippocampal slices with normoxic medium containing no added sodium resulted in a rapid loss of the CA1 population spike, with only 35 +/- 10% (S.E.M.) (P < 0.001) recovery after a 15 min exposure. This injury was prevented by the non-competitive N-methyl-D-aspartate (NMDA) antagonist MK-801 (93 +/- 4% rec...

journal_title：Brain research

authors： Parsons JE,Wallis RA,Panizzon KL,Wasterlain CG

更新日期：1992-11-06 00:00:00

abstract：:Neurogenesis might influence oligodendrogenesis and selectively instruct myelination in the mammalian brain. Running exercise could induce neurogenesis and protect the myelin sheaths in the dentate gyrus of AD mice. It is unclear whether running exercise can protect myelin sheaths in the absence of neurogenesis in the...

journal_title：Brain research

authors： Chao FL,Zhang L,Zhang Y,Zhou CN,Jiang L,Xiao Q,Luo YM,Lv FL,He Q,Tang Y

更新日期：2018-04-01 00:00:00

abstract：:Human truncated tau protein is an active constituent of the neurofibrillary degeneration in sporadic Alzheimer's disease. We have shown that modified tau protein, when expressed as a transgene in rats, induced AD characteristic tau cascade consisting of tau hyperphosphorylation, formation of argyrophilic tangles and s...

journal_title：Brain research

authors： Hrnkova M,Zilka N,Minichova Z,Koson P,Novak M

更新日期：2007-01-26 00:00:00

abstract：:An enriched environment has been shown to improve cognitive, behavioral and histopathological outcome after focal cerebral ischemia and head trauma. The purpose of this study was to determine the effect of an enriched environment on histopathology following global cerebral ischemia. Wistar rats (21 weeks of age) were ...

journal_title：Brain research

authors： Belayev A,Saul I,Liu Y,Zhao W,Ginsberg MD,Valdes MA,Busto R,Belayev L

更新日期：2003-02-21 00:00:00

abstract：:Double-staining in either vibratome or paraffin sections using contrasting chromogens revealed an alpha-melanocyte-stimulating hormone (alpha-MSH)-containing cell group in the arcuate nucleus, a metorphamide-containing cell group in the paraventricular hypothalamus, and an extensive group of magnocellular perikarya in...

journal_title：Brain research

authors： Merchenthaler I,Maderdrut JL,Weber E,Petrusz P

更新日期：1988-06-14 00:00:00

abstract：:Astrocytes associated with beta-amyloid (Aβ)-deposited senile plaques are a common neuropathological feature of Alzheimer's disease (AD). There is little doubt that the association of Aβ with the major component in the central nervous system cells significantly influences disease progression, however, the molecular me...

journal_title：Brain research

authors： Satoh K,Akatsu H,Yamamoto T,Kosaka K,Yokota H,Yamada T

更新日期：2012-03-02 00:00:00

abstract：:SC1 is an extracellular matrix glycoprotein that is related to the multifunctional protein SPARC. These matricellular members play regulatory roles in modulating cellular interactions. SC1 expression is enriched in the central nervous system during embryonic and postnatal development as well as in the adult brain. In ...

journal_title：Brain research

authors： Mothe AJ,Brown IR

更新日期：2002-03-29 00:00:00

abstract：:Leumorphin, an opioid peptide whose functions are unknown, is found in mammalian brain and pituitary and stimulates lordosis behavior in estrogen-treated female rats. To elucidate the role of leumorphin in the physiological control of female sexual behavior, the levels of immunoreactive (ir) leumorphin as well as ir d...

journal_title：Brain research

authors： Suda M,Nakao K,Sakamoto M,Morii N,Sugawara A,Imura H

更新日期：1986-05-28 00:00:00

abstract：:Beta-amyloid (Aβ)-mediated inflammation plays a critical role in the initiation and progression of Alzheimer׳s disease (AD). Anti-inflammatory treatment may provide therapeutic benefits. In this study, the effect of hydroxy-safflor yellow A (HSYA) on Aβ1-42-induced inflammation in AD mice was investigated and the unde...

journal_title：Brain research

authors： Zhang ZH,Yu LJ,Hui XC,Wu ZZ,Yin KL,Yang H,Xu Y

更新日期：2014-05-14 00:00:00

abstract：:Functional magnetic resonance imaging studies on episodic memory (EM) retrieval have used a variety of paradigms/contrasts to yield many diverse findings, which raises the need for an integrative multifactorial view. To address this need, I begin by proposing a fourstage, quasi-sequential model of network activity dur...

journal_title：Brain research

authors： Kim H

更新日期：2020-11-15 00:00:00

abstract：:To investigate the role of the estrogen receptor (ER) in mediating neuroprotection, the neuroprotective profiles of selective ER agonists for ERalpha and ERbeta, propylpyrazole triol (PPT) and 2,3-bis(4-hydroxyphenyl) proprionitrile (DPN), respectively, were compared to that of 17beta-estradiol and 17alpha-estradiol i...

journal_title：Brain research

authors： Cordey M,Pike CJ

更新日期：2005-05-31 00:00:00

abstract：:In freely-moving rats treated with a combination of reserpine (10 mg/kg, i.p.) and scopolamine (5 mg/kg, i.p.), neocortical low voltage fast activity (LVFA) associated with continuous multiunit activity (MUA) was abolished and replaced by 2-6 Hz large irregular slow activity (LISA) above 1.5 mV associated with a burst...

journal_title：Brain research

authors： Dringenberg HC,Vanderwolf CH

更新日期：1996-07-29 00:00:00

abstract：:Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...

journal_title：Brain research

authors： Cummings A,Seddoh A,Jallo B

更新日期：2016-03-15 00:00:00

abstract：:7-Chlorokynurenic acid (7-Cl KYNA) has been reported to attenuate N-methyl-D-aspartate (NMDA) receptor functioning by a potent and selective inhibitory action mediated at the strychnine-insensitive glycine recognition site of the NMDA complex. Here we report that 7-Cl KYNA dose-dependently inhibits [3H]MK-801 binding ...

journal_title：Brain research

authors： Sircar R,Frusciante MJ,Javitt DC,Zukin SR

更新日期：1989-12-18 00:00:00

abstract：:Whole cell and perforated patch clamp experiments were conducted on cultured cortical rat neurones (7-21 days in vitro) in order to determine the effects of the anticonvulsant and glutamate release inhibitor Lamotrigine (10-100 microM), on CNS receptors and ion channels. The compound inhibited, indiscriminately, both ...

journal_title：Brain research

authors： Lees G,Leach MJ

更新日期：1993-05-28 00:00:00

abstract：:Error processing during motor control involves the evaluation of "high-level" errors (i.e., failures to meet a system goal) by a frontal system involving anterior cingulate cortex and the evaluation of "low-level" errors (i.e., discrepancies between actual and desired motor commands) by a posterior system involving po...

journal_title：Brain research

authors： Krigolson OE,Holroyd CB

更新日期：2007-06-25 00:00:00

abstract：:Aspartame (L-aspartyl-L-phenylalanine methyl ester), an artificial low-calorie sweetener, was shown to dose-dependently inhibit L-[3H]glutamate binding to its N-methyl-D-aspartate-specific receptors. L-Aspartic acid, a major endogenous metabolite of aspartame, inhibited the binding more stronger than aspartame, while ...

journal_title：Brain research

authors： Pan-Hou H,Suda Y,Ohe Y,Sumi M,Yoshioka M

更新日期：1990-06-18 00:00:00

abstract：:Loss of dopaminergic neurons from the pars compacta of the substantia nigra is the pathological hallmark of Parkinson's disease (PD) and results in a partial deafferentation to the striatum. Since deafferentation is known to induce transynaptic atrophy of postsynaptic cells, we examined by Golgi impregnation the morph...

journal_title：Brain research

authors： McNeill TH,Brown SA,Rafols JA,Shoulson I

更新日期：1988-07-05 00:00:00

abstract：OBJECTIVE:There is an increasing interest concerning the contribution of astrocytes to the intrinsic bioremediation of ischemic brain injury. The aim of this work was to disclose the effects and mechanism of dexmedetomidine (DEX) on the apoptosis of astrocytes under oxygen glucose deprivation (OGD) condition. METHODS:...

journal_title：Brain research

authors： Feng P,Zhang A,Su M,Cai H,Wang X,Zhang Y

更新日期：2021-01-01 00:00:00

abstract：:Following cholinergic denervation of the hippocampus by medial septal lesions, and unusual neuronal reorganization occurs, in which peripheral sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. Previously, we have found that both hippocampal sympathetic ingrowth (HSI) and ch...

journal_title：Brain research

authors： Harrell LE,Kolasa K,Parsons DS,Ayyagari V

更新日期：1995-04-10 00:00:00

abstract：:It is well documented that VMAT2 protects nigrostriatal DA neurons against MPP(+) by sequestering it inside vesicles away from its mitochondrial site of neurotoxic action. However, the implication of the VMAT2 in the mechanism of action exerted by 6-OHDA has received little attention. Therefore, the aim of the present...

journal_title：Brain research

authors： Cleren C,Naudin B,Costentin J

更新日期：2003-11-07 00:00:00

abstract：:Natural food sources constitute a promising source of new compounds with neuroprotective properties, once they have the ability to reach the brain. Our aim was to evaluate the brain accessibility of quercetin, epigallocatechin gallate (EGCG) and cyanidin-3-glucoside (C3G) in relation to their neuroprotective capabilit...

journal_title：Brain research

authors： Pogačnik L,Pirc K,Palmela I,Skrt M,Kim KS,Brites D,Brito MA,Ulrih NP,Silva RF

更新日期：2016-11-15 00:00:00

abstract：:Aluminum (Al) concentrations of the rat frontal cortex, parietal cortex, and hippocampus were measured by atomic absorption spectroscopy 16 days after a unilateral intracerebroventricular injection of Na gluconate, Al gluconate, or the cholinotoxin AF64A. A fourth group of rats were injected with AF64A 6 days before i...

journal_title：Brain research

authors： Szerdahelyi P,Kása P

更新日期：1988-03-22 00:00:00

abstract：:These experiments provide a direct test of the hypothesis that median raphe lesion- or PCPA-induced hyperactivity in the rat is mediated specifically by the hippocampus. Previous studies had shown that a marked depletion of hippocampal serotonin accompanied median lesion-induced hyperactivity. In the present studies, ...

journal_title：Brain research

authors： Jacobs BL,Trimbach C,Eubanks EE,Trulson M

更新日期：1975-08-29 00:00:00

abstract：:Horeradish peroxidase was injected at multiple sites in the mandibular and sublingual salivary glands in order to label the preganglionic salivatory neurons in the brain stem. The same injections resulted in retrograde labeling of the sympathetic and sensory neurons that project to these glands. Labeled fusiform and m...

journal_title：Brain research

authors： Chibuzo GA,Cummings JF

更新日期：1980-05-12 00:00:00

abstract：:The distribution of immunoreactive (IR) axons and neurons in the rat central nervous system (CNS) has been studied with an antiserum directed against the C-terminal sequence of rat a-calcitonin gene-related peptide (CGRP) and a durable peroxidase reaction product for detailed analysis in relation to normal cytoarchite...

journal_title：Brain research

authors： Kruger L,Mantyh PW,Sternini C,Brecha NC,Mantyh CR

更新日期：1988-11-01 00:00:00

abstract：:Marmoset monkeys (Callithrix jacchus) with bilateral transections of the anterior temporal stem, amygdala and fornix were unable to relearn a 2-choice object discrimination first learnt prior to surgery, and were very severely impaired at relearning a concurrent object discrimination task which they had learnt and rel...

journal_title：Brain research

authors： Maclean CJ,Gaffan D,Baker HF,Ridley RM

更新日期：2001-01-05 00:00:00

abstract：:Binding activities specific for each of [3H]prostaglandin (PG) D2, E2 and F2 alpha were detected in the P2 fraction of the human brain homogenates. The bindings were time-dependent, saturable and of high affinity; Kd values were 30 nM for all the PG bindings. Regional distribution of these binding activities was deter...

journal_title：Brain research

authors： Watanabe Y,Tokumoto H,Yamashita A,Narumiya S,Mizuno N,Hayaishi O

更新日期：1985-09-02 00:00:00

abstract：:Anterograde and retrograde tracing experiments employing WGA-HRP were used to identify an auditory projection area within the frontal telencephalon of the pigeon. The projection originates in a nucleus of the lateral lemniscus, travels with the quintofrontal tract and terminates within nucleus basalis. The location of...

journal_title：Brain research

authors： Arends JJ,Zeigler HP

更新日期：1986-11-29 00:00:00