Abstract：
:Error processing during motor control involves the evaluation of "high-level" errors (i.e., failures to meet a system goal) by a frontal system involving anterior cingulate cortex and the evaluation of "low-level" errors (i.e., discrepancies between actual and desired motor commands) by a posterior system involving posterior parietal cortex. We have recently demonstrated that high-level errors committed within the context of a continuous tracking task elicited an error-related negativity (ERN) -- a component of the event-related brain potential (ERP) generated within medial-frontal cortex that is sensitive to error commission. The purpose of the present study was to demonstrate that low-level motor errors do not elicit an ERN, but may instead evoke other ERP components associated with visual processing and online motor control. Participants performed a computer aiming task in which they manipulated a joystick to move a cursor from a start to a target position. On a random subset of trials the target jumped to a new position at movement onset, requiring the participants to modify their current motor command. Further, on one half of these "target perturbation" trials the cursor did not respond to corrective movements of the joystick. Consistent with our previous findings, we found that the uncorrectable errors elicited an ERN. We also found that the target perturbations on both correctable and uncorrectable trials did not elicit an ERN, but rather evoked two other ERP components, the N100 and P300. These results suggest that medial-frontal cortex is insensitive to low-level motor errors, and are in line with a recent theory that holds that the P300 reflects stimulus-response optimization by the impact of locus coeruleus activity on posterior cortex.
journal_name
Brain Resjournal_title
Brain researchauthors
Krigolson OE,Holroyd CBdoi
10.1016/j.brainres.2007.04.024subject
Has Abstractpub_date
2007-06-25 00:00:00pages
70-80eissn
0006-8993issn
1872-6240pii
S0006-8993(07)00909-2journal_volume
1155pub_type
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