Tetanic stimulation affects the metabolism of phosphoinositides in hippocampal slices.

Abstract:

:Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of other, non-inositol lipids was not affected by the high frequency stimulation. The observed changes in phosphoinositide metabolism are complex and biphasic, lasting at least 4 h after the termination of the tetanus. The present data support the notion that membrane phosphoinositides play a role in synaptic function.

journal_name

Brain Res

journal_title

Brain research

authors

Bär PR,Wiegant F,Lopes da Silva FH,Gispen WH

doi

10.1016/0006-8993(84)90198-7

subject

Has Abstract

pub_date

1984-11-12 00:00:00

pages

381-5

issue

2

eissn

0006-8993

issn

1872-6240

pii

0006-8993(84)90198-7

journal_volume

321

pub_type

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