Brief ganglioside treatment produces delayed enhancement of functional recovery after medial septal lesions.


:The effects of a 5-day ganglioside (GM1) treatment (30 mg/kg) on body weight and water intake subsequent to medial septal lesions were evaluated for 44 consecutive days. In addition, activity, rearing, and repetitive motor acts were measured on postsurgery days 5, 10, 40, and 60. The rate of increase in the body weights of rats with medial septal lesions treated with GM1 was equivalent to that of controls, while untreated rats with such lesions had reduced body weights. Rats with medial septal lesions treated with GM1 also exhibited movement times and frequency of repetitious motor acts similar to those of control rats by postsurgery day 60. No differences were found in water intake between any of the groups. Rats with medial septal lesions, whether treated with GM1 or not, had equivalent frequencies of rearings that were lower than control rats. This study emphasizes that even brief regimes of GM1 administration can exert behavioral changes in brain-damaged rats well after the treatment was administered, i.e. 40-60 days after surgery.


Brain Res


Brain research


Poplawsky A,Isaacson RL




Has Abstract


1989-08-28 00:00:00














  • Immunocytochemical localization of non-NMDA ionotropic excitatory amino acid receptor subunits in human neocortex.

    abstract::The distribution of immunocytochemically localized subunits that comprise ionotropic non-NMDA excitatory amino acid receptors was examined in human frontal, parietal and temporal association neocortex. AMPA/kainate receptor subunits were identified using a monoclonal antibody (3A11) that recognizes an epitope common t...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Vickers JC,Huntley GW,Hof PR,Bederson J,DeFelipe J,Morrison JH

    更新日期:1995-02-06 00:00:00

  • Proteomic analysis of rat cortical neurons after fluoxetine treatment.

    abstract::The known neurochemical effect of most currently available antidepressants is the enhancement of the synaptic levels of monoamine neurotransmitters. However, the existence of other mechanisms has been suggested to justify the significant delay between the modulation of the monoaminergic system and the clinical effects...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cecconi D,Mion S,Astner H,Domenici E,Righetti PG,Carboni L

    更新日期:2007-03-02 00:00:00

  • Presynaptic facilitation by tetracaine of glutamatergic spontaneous excitatory transmission in the rat spinal substantia gelatinosa - Involvement of TRPA1 channels.

    abstract::The amide-type local anesthetic (LA) lidocaine activates transient receptor potential (TRP) ankyrin-1 (TRPA1) channels to facilitate spontaneous l-glutamate release onto spinal substantia gelatinosa (SG) neurons, which play a crucial role in regulating nociceptive transmission. In contrast, the ester-type LA procaine ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Piao LH,Fujita T,Yu T,Kumamoto E

    更新日期:2017-02-15 00:00:00

  • Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse.

    abstract::It is suggested that altered neuroplasticity contributes to the pathophysiology of schizophrenia and antipsychotics may exhibit some of their therapeutic efficacies by improving neurogenesis and/or proliferation of neural progenitors. The aim of this study is to investigate whether chronic antipsychotics treatment aff...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chikama K,Yamada H,Tsukamoto T,Kajitani K,Nakabeppu Y,Uchimura N

    更新日期:2017-12-01 00:00:00

  • Region-specific alterations of calbindin-D28k immunoreactivity in the rat hippocampus following adrenalectomy and corticosterone treatment.

    abstract::The aim of this study was (i) to compare the immunocytochemical distribution of the calcium-binding protein calbindin-D28k (CB) in the hippocampus of rats with the pattern of neurodegeneration following adrenalectomy (ADX) using silver impregnation, and (ii) to investigate the CB-immunoreactivity in the hippocampus fo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Krugers HJ,Medema RM,Postema F,Korf J

    更新日期:1995-10-23 00:00:00

  • The adenosine binding enhancer, PD 81,723, inhibits epileptiform bursting in the hippocampal brain slice.

    abstract::The effects of adenosine and the adenosine binding enhancer, PD 81,723, on low magnesium-induced bursting in the in vitro hippocampal slice were examined. Extracellular recordings were obtained from the CA3 pyramidal cell layer while electrically stimulating in the stratum radiatum under low magnesium perfusion. Adeno...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Janusz CA,Berman RF

    更新日期:1993-08-13 00:00:00

  • C3H/HeJ mice are refractory to lipopolysaccharide in the brain.

    abstract::C3H/HeJ mice are refractory to lipolysaccharide (LPS) in the periphery, primarily because their macrophages do not respond to LPS and produce pro-inflammatory cytokines such as interleukin-1 (IL-1). To determine if they are also refractory to LPS in the brain, behavior of C3H/HeJ mice was compared to LPS-sensitive C3H...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Johnson RW,Gheusi G,Segreti S,Dantzer R,Kelley KW

    更新日期:1997-03-28 00:00:00

  • Phonological code retrieval during picture naming: Influence of consonant class.

    abstract::Investigations of the time course of various stages of lexical processing have indicated either early or late onset of brain activation for phonological code retrieval. The basis of the differential findings is unclear, but factors related to segmental phonology appear to be part of it. The purpose of the present stud...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cummings A,Seddoh A,Jallo B

    更新日期:2016-03-15 00:00:00

  • Effect of nitric oxide on mitogenesis and proliferation of cerebellar glial cells.

    abstract::In the brain, nitric oxide (NO) has been identified as a messenger molecule and a mediator of excitatory amino acid-induced neurotoxicity. In this study, the effects of NO on serum-induced mitogenesis and cell proliferation of the cerebellar glial cells were assessed. NO-generating agent, S-nitroso-N-acetylpenicillami...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Garg UC,Devi L,Turndorf H,Goldfrank LR,Bansinath M

    更新日期:1992-10-02 00:00:00

  • Dissociation of IGF2 and H19 imprinting in human brain.

    abstract::The human IGF2 and H19 genes are imprinted in most normal tissues. Alterations of genomic imprinting or loss of imprinting (LOI) have been observed in a number of malignant tumors. Although LOI has been linked to tumorigenesis, loss of IGF2 imprinting has also been observed in choroid plexus and leptomeninges in norma...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pham NV,Nguyen MT,Hu JF,Vu TH,Hoffman AR

    更新日期:1998-11-09 00:00:00

  • Involvement of M1 muscarinic receptors in the initiation of cholinergically induced epileptic seizures in the rat brain.

    abstract::The present study was designed to determine the types of acetylcholine receptors involved in the initiation of epileptic seizures from the zona incerta and surrounding structures by cholinergic stimulation in rats. Unilateral intracerebral microinjection of the mixed muscarinic and nicotinic agonist carbachol (3 micro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cruickshank JW,Brudzynski SM,McLachlan RS

    更新日期:1994-04-18 00:00:00

  • Hemoglobin as a novel protein developmentally regulated in neurons.

    abstract::We have attempted to identify some novel genes which were found to be more highly expressed in the embryonic brain than in the adult brain. Consequently, one of these clones was identified as alpha-globin cDNA. Actually, alpha-globin mRNA was detected in the neurons. In addition, beta-globin mRNA was detected in the n...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ohyagi Y,Yamada T,Goto I

    更新日期:1994-01-28 00:00:00

  • Superior colliculus stimulation enhances neocortical serotonin release and electrocorticographic activation in the urethane-anesthetized rat.

    abstract::Recent evidence indicates that the superior colliculus (SC), in addition to its functions in sensory detection, also participates in controlling the generalized activation state of the forebrain, as measured by the electroencephalogram (EEG) or electrocorticogram (ECoG). The mechanisms by which the SC modulates forebr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Dringenberg HC,Vanderwolf CH,Noseworthy PA

    更新日期:2003-02-21 00:00:00

  • The endogenous lectin RL-29 is transynaptically induced in dorsal horn neurons following peripheral neuropathy in the rat.

    abstract::Neurons containing immunoreactivity to the endogenous lactose-binding lectin, RL-29, were examined in the L4 segment of the spinal cord of rats with an experimental neuropathy. The cells appeared by 5 days and were also present at 14 and 28 days postoperatively. All neurons were found in the dorsal horn ipsilateral to...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cameron AA,Dougherty PM,Garrison CJ,Willis WD,Carlton SM

    更新日期:1993-08-20 00:00:00

  • Cerebrospinal fluid (CSF) and brain monoamine metabolites in the developing rat pup.

    abstract::Concentrations of the neurotransmitters, serotonin (5-HT), dopamine (DA), and norepinephrine (NE) were measured in the developing rat brain at 12, 19, 26 and 42 days of age. The amino acid precursors, tryptophan (TRP) and tyrosine (TYR) were measured along with the 5-HT and DA metabolites, 5-hydroxyindoleacetic acid (...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shaywitz BA,Anderson GM,Cohen DJ

    更新日期:1985-01-01 00:00:00

  • Localization of the NBMPR-sensitive equilibrative nucleoside transporter, ENT1, in the rat dorsal root ganglion and lumbar spinal cord.

    abstract::ENT1 is an equilibrative nucleoside transporter that enables trans-membrane bi-directional diffusion of biologically active purines such as adenosine. In spinal cord dorsal horn and in sensory afferent neurons, adenosine acts as a neuromodulator with complex pro- and anti-nociceptive actions. Although uptake and relea...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Governo RJ,Deuchars J,Baldwin SA,King AE

    更新日期:2005-10-19 00:00:00

  • Input-rate modulation of γ oscillations is sensitive to network topology, delays and short-term plasticity.

    abstract::Simulated networks of excitatory and inhibitory neurons have previously been shown to reproduce critical features of experimental data regarding neural coding in V1, such as a positive relationship between thalamic input spike rate and the power of gamma frequency oscillations. This effect, referred to as modulated ga...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: McDonnell MD,Mohan A,Stricker C,Ward LM

    更新日期:2012-01-24 00:00:00

  • Heterosynaptic stimulation modulates the duration of post-tetanic potentiation at an Aplysia synapse without affecting other aspects of synaptic transmission.

    abstract::Repetitive stimulation of an axon in the right visceropleural connective to the abdominal ganglion of Aplysia californica produces post-tetanic potentiation (PTP) of a unitary monosynaptic EPSP recorded from cell R15. PTP decays within one half hour following cessation of repatitive stimulation. Stimulation of the lef...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Newlin SA,Schlapfer WT,Barondes SH

    更新日期:1980-01-06 00:00:00

  • Dopaminergic regulation of prolactin and growth hormone synthesis in rat pituitary tumor cells.

    abstract::The dopaminergic regulation of prolactin (PRL) and growth hormone (GH) synthesis were studied in monolayer cultures of rat pituitary tumor (GH3) cells. PRL synthesis could not be inhibited by dopamine at concentrations ranging from 10(-9) to 10(-5) M. Bromocriptine inhibited PRL synthesis only at the very high concent...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cheung CY,Melmed S,Braunstein GD

    更新日期:1983-06-27 00:00:00

  • Presence of synapsin I in afferent and efferent nerve endings of vestibular sensory epithelia.

    abstract::The presence and localization of synapsin I were investigated in the cat vestibular epithelium, using a rabbit anti-synapsin I antibody. The staining was performed by immunofluorescence or by a peroxidase-anti-peroxidase technique. A strong immunoreactivity was observed with both methods. It appeared as spherical patc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Favre D,Scarfone E,Di Gioia G,De Camilli P,Dememes D

    更新日期:1986-10-08 00:00:00

  • Pre- and postsynaptic actions of valproic acid at the frog neuromuscular junction.

    abstract::The effect of valproic acid (VPA) on synaptic transmission was investigated at the frog neuromuscular junction using electrophysiological methods. The drug caused a dose-dependent decrease in the quantal content of the endplate potential (EPP) and a significant reduction in the input resistance of the postjunctional m...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Alkadhi KA,Banks FW

    更新日期:1984-07-23 00:00:00

  • Immunocytochemical localization of glutamic acid decarboxylase (GAD) and glutamine synthetase (GS) in the area postrema of the cat. Light and electron microscopy.

    abstract::The present study was designed to investigate the existence of two key enzymes involved in the metabolism of gamma-aminobutyric acid, glutamic acid decarboxylase (GAD) and glutamine synthetase (GS), in the area postrema (AP) of the cat. The results showed that punctuate structures of variable size corresponding to axo...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: D'Amelio FE,Mehler WR,Gibbs MA,Eng LF,Wu JY

    更新日期:1987-05-05 00:00:00

  • Immunocytochemical staining of neuropeptide Y (NPY) in the insular lobe of the monkey: a light microscopic study.

    abstract::Neuropeptide Y (NPY) has been detected immunocytochemically in cerebral cortex and subcortical white matter of the primate frontal, parietal, temporal, and occipital lobes. Because little is known about NPY in the primate insular lobe and because peptides play an important role in normal neuronal functioning and alter...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Augustine JR,Mascagni F,McDonald AJ,Blake CA

    更新日期:1993-02-19 00:00:00

  • Photoperiodic dependent changes in the number of neurons containing mRNA encoding neuropeptide Y in the intergeniculate leaflet of the Syrian hamster.

    abstract::The intergeniculate leaflet (IGL) is a distinct division of the lateral geniculate complex that participates in the regulation of the circadian rhythm through its projections to the circadian pacemaker located in the suprachiasmatic nuclei of the hypothalamus. A high number of neuropeptide Y (NPY) cell bodies has been...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Jacob N,Vuillez P,Moller M,Pévet P

    更新日期:1998-11-30 00:00:00

  • Interleukin 2 modifies the bioelectric activity of some neurosecretory nuclei in the rat hypothalamus.

    abstract::Introduction of 15-30 U of interleukin-2 (IL-2) into the 3rd ventricle of Wistar rats was followed by a marked and significant decrease in neuron discharge frequency in the ventromedial nucleus of hypothalamus and a marked increase in the supraoptic and paraventricular nuclei. The monoclonal antibody ART62 partly bloc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Bindoni M,Perciavalle V,Berretta S,Belluardo N,Diamantstein T

    更新日期:1988-10-11 00:00:00

  • Biochemical characterization of the intramembrane interaction between neurotensin and dopamine D2 receptors in the rat brain.

    abstract::In order to better understand the neuroleptic-like effects of neurotensin in vivo, the effects of neurotensin in vitro on dopamine D2 and D1 agonist and antagonist binding sites were characterized in membranes from the neostriatum and the subcortical limbic area. Neurotensin increased the KD but not the Bmax value of ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: von Euler G

    更新日期:1991-10-04 00:00:00

  • The effects of opioid receptor antagonists on electroacupuncture-produced anti-allodynia/hyperalgesia in rats with paclitaxel-evoked peripheral neuropathy.

    abstract::Research supports the effectiveness of acupuncture for conditions such as chronic low back and knee pain. In a five-patient pilot study the modality also improved the symptoms of chemotherapy-induced neuropathic pain. Using an established rat model of paclitaxel-induced peripheral neuropathy, we evaluated the effect o...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Meng X,Zhang Y,Li A,Xin J,Lao L,Ren K,Berman BM,Tan M,Zhang RX

    更新日期:2011-09-26 00:00:00

  • Quantitative immunoelectron microscopy and tannic acid study of dynamics of neurohaemal and non-synaptic peptide release by the caudodorsal cells of Lymnaea stagnalis.

    abstract::The caudodorsal cells (CDCs) of the freshwater snail Lymnaea stagnalis control egg laying and egg-laying associated behaviours by releasing various peptides including the ovulation hormone CDCH. Previously it has been shown that release occurs (1) into the haemolymph from neurohaemal axon terminals in the outer compar...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schmidt ED,Roubos EW

    更新日期:1989-06-12 00:00:00

  • Evidence that the deficit in sexual behavior in adult rats neonatally exposed to citalopram is a consequence of 5-HT1 receptor stimulation during development.

    abstract::Neonatal (postnatal days 8-21) exposure of rats to the selective serotonin reuptake inhibitor (SSRI), citalopram, results in persistent changes in behavior including decreased sexual activity in adult animals. We hypothesized that this effect was a consequence of abnormal stimulation of 5-HT(1A) and/or 5-HT(1B) recept...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Maciag D,Coppinger D,Paul IA

    更新日期:2006-12-13 00:00:00

  • Cardiovascular responses to electrical stimulation of the ventrolateral medulla of the spontaneously hypertensive rat.

    abstract::Cardiovascular responses to electrical microstimulation of the ventrolateral medulla were investigated in both Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) under pentobarbital anesthesia. The threshold intensity required to elicit a change in blood pressure (BP) and the cardiovascular responses in...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chan RK,Chan YS,Wong TM

    更新日期:1990-07-02 00:00:00