Abstract:
:The ability to recognize previous experience depends on two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection, slower-acting and more effortful. Familiarity appears to mature relatively early in development and is maintained with aging, whereas recollection shows protracted development and deteriorates with aging. To assess this model, ERP and behavioral data were recorded in children (9-10 years), adolescents (13-14), young (20-30) and older (65-85) adults during a recognition memory task in which the same items were studied and tested over four cycles. Participants decided whether each item was old or new and then whether the decision was associated with (Remember, R) or without (Know, K) contextual detail. Memory sensitivity was greatest in young adults, although all groups showed increases in memory sensitivity and R judgments with repetition. Familiarity-based processes (mid-frontal episodic memory, EM, effect) appeared to be used by adolescents, young and older adults, but apparently not to the same extent by children. Recollection-based processes (parietal EM effect) were recruited by children, adolescents and young adults, but to a much lesser extent by older adults. Repetition enhanced the parietal effect in all but older adults. However, post-hoc analyses indicated that reduced recollective processing was confined to poor-performing older adults. By contrast, children appeared to rely mainly on recollection concordant with their conservative decision criteria across tests. We conclude that episodic-memory development reflects the increasingly flexible and interchangeable use of familiarity and recollection with a breakdown in the latter at older ages, perhaps limited to poor-performing older adults.
journal_name
Brain Resjournal_title
Brain researchauthors
Friedman D,de Chastelaine M,Nessler D,Malcolm Bdoi
10.1016/j.brainres.2009.11.016subject
Has Abstractpub_date
2010-01-15 00:00:00pages
124-41eissn
0006-8993issn
1872-6240pii
S0006-8993(09)02442-1journal_volume
1310pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The myosin S-1 subfragment was used to label actin filaments in the developing rat brain. The results show actin filaments present throughout the dendritic region with highest concentrations within growth cones and regions of spine development. Between 6 and 25 days postnatal, spines became more complex and actin fila...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90253-1
更新日期:1986-06-01 00:00:00
abstract::Both nictitating membrane extension and eyelid EMG activity were measured during classical conditioning of rabbits to tone-airpuff pairings. Both measures were highly correlated. Over trials, learning criterion was met earlier with eyelid EMG activity than with nictitating membrane extension. Within a trial, eyelid EM...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91419-h
更新日期:1990-04-30 00:00:00
abstract::To elucidate the role of the large conductance calcium-activated potassium channel (BK(Ca) channel) in the production of bursting activity, which is characteristic of convulsions, effects of iberiotoxin (IbTX), a selective blocker of the BK(Ca) channel, on bursting activity, induced by various procedures were examined...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)01943-0
更新日期:2000-03-31 00:00:00
abstract::The effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its putative toxic metabolite 1-methyl-4-phenylpyridinium ion MPP+ were studied with specific neuronal and glial cell lines in vitro. MPTP had no morphological effect on actively growing neuroblastoma N2AB-1 cells or C6 glioma cells nor did it affe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90225-9
更新日期:1988-07-26 00:00:00
abstract::Reports suggested that the predominant site of action for the antihypertensive effects of clonidine is the rostral ventrolateral medulla (RVL), the presumed tonic vasomotor center. This study examined whether clonidine directly interacts with nerve terminal alpha 2-adrenergic receptors in the RVL to inhibit the releas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90355-f
更新日期:1990-12-24 00:00:00
abstract::Vagus nerve stimulation (VNS) has been used for years to treat patients with drug-resistant epilepsy. In the present study, the effect of different stimulation protocols of VNS on the hippocampal formation (HPC) type II theta field potentials were evaluated in anesthetized rats. The following theta parameters were ana...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.08.030
更新日期:2017-11-15 00:00:00
abstract::The morphology, dendritic stratification and laminal position of the soma of retinal ganglion cells were analyzed in Golgi preparations and in other rabbit retinas containing cells backfilled from the superior colliculus. Only one type, among 40 Golgi-impregnated types identified, always had its cell body displaced to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91838-8
更新日期:1990-12-03 00:00:00
abstract::Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.06.034
更新日期:2012-08-27 00:00:00
abstract::Projection neurons from the superior colliculus (SC) to the cuneiform region (CFR) of the midbrain form distinct cell clusters in the intermediate gray layer which precisely overlap the cholinergic fiber patches in this region of the cat SC (Jeon and Mize, J. Comp. Neurol., 337 (1993) 127-150). The acetylcholine (ACh)...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00563-x
更新日期:1996-09-16 00:00:00
abstract::From 4 or 5 postnatal days, rat pups were either reared by their mothers (MR) or artificially reared (AR) without their mothers by infusion of 'milk' through a gastric cannula. In AR, but not MR, pups the left eye was more likely to open first than the right eye (P less than 0.001). The left-biassed eye-opening of AR ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(86)90073-8
更新日期:1986-07-01 00:00:00
abstract::Soluble guanylyl cyclase is a heterodimeric (alpha, beta) enzyme generating the second messenger, cGMP, upon activation by the gaseous messenger, nitric oxide. The occurrence and distribution of alpha 1-, alpha 2-, beta 1- and beta 2-subunits were investigated in trigeminal and dorsal root ganglia on the mRNA and the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00097-2
更新日期:1996-05-20 00:00:00
abstract::Electrical synaptic transmission via gap junctions has become an accepted feature of neuronal communication in the mammalian brain, and occurs often between dendrites of interneurons in major brain structures, including the hippocampus. Electrical and dye-coupling has also been reported to occur between pyramidal cell...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.05.064
更新日期:2012-12-03 00:00:00
abstract::Abeta amyloidosis and tauopathy are characteristic changes in the brain of Alzheimer's disease. Although much evidence suggests that Abeta deposit is a critical initiation factor, the pathological pathway between Abeta amyloidosis and tau accumulation remains unclear. Tau accumulation was examined in the doubly transg...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.12.134
更新日期:2006-06-13 00:00:00
abstract::Previous research has shown that, in freely moving laboratory rats, the odors of benzyl alcohol, camphor, carvacrol, isopentenyl methyl sulfide, 2-propylthietane, salicylaldehyde, trimethylthiazoline, and xylene (plus other compounds) elicit high amplitude bursts of roughly 20-Hz waves (beta-waves) in the olfactory bu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03225-5
更新日期:2002-01-11 00:00:00
abstract::Spontaneous intracerebral hemorrhage (ICH) is one of the most devastating subtypes of stroke. Since angiogenesis is a fundamental process to brain development and repair by new blood vessel formation from pre-existing ones, mediated by numerous angiogenic factors including vascular endothelial growth factor (VEGF), th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.08.028
更新日期:2007-10-17 00:00:00
abstract::Excitatory actions of acromelic acid were investigated in the isolated newborn rat spinal cord. Test compounds were added to the perfusing fluid and the responses were recorded from the ventral root extracellularly. Acromelic acid caused a depolarizing response in a dose-dependent manner and the depolarizing activity ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90456-8
更新日期:1988-12-06 00:00:00
abstract::In view of the use of synthetic propentofylline (PPF) as a protective agent in brain ischemia, its possible side effects on vision capacities have been explored by electroretinography in comparative experiments with theophylline. We used eyecup preparations of small-spotted dogfish sharks and of European eels, particu...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02328-3
更新日期:2000-06-23 00:00:00
abstract::Neurons immunoreactive for the calcium-binding protein calretinin (CR) were visualized in the substantia nigra (SN) pars compacta (SNc), reticulata (SNr) and lateralis (SNl), the ventral tegmental area (VTA) and the subthalamic nucleus (STN) of squirrel monkeys. The density of CR perikarya was high in VTA, moderate in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01374-1
更新日期:1996-02-05 00:00:00
abstract::Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate brain. GABA activates both ionotropic (GABA(A)) and metabotropic (GABA(B)) receptors in mammals. Whether non-mammalian vertebrates possess receptors with similar characteristics is not well understood. We used a mammalian GABA(B)-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.008
更新日期:2006-06-13 00:00:00
abstract::Fluoro-Gold has been used previously to identify those trigeminal ganglion cells that innervate the central cornea. To examine the effects of Fluoro-Gold treatment on infection and spread of HSV in vivo, we measured the number of plaque forming units recovered from trigeminal ganglia 3 or 5 days after corneal scratch ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90137-c
更新日期:1993-10-15 00:00:00
abstract::Synapses from Mauthner to giant fibers in the hatchetfish are chemically transmitting excitatory axo-axonic synapses located in the medulla. The synapses are 4--10 mum in diameter and easily identified for electron microscopy. Presynaptic vesicles are clustered near the contact regions and are round, clear and 40-60 n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90002-5
更新日期:1975-11-14 00:00:00
abstract::Prominent cellular responses to axonal interruption include enhanced synthesis of RNA and protein in the neuronal perikaryon, and proliferation of reactive Schwann cells. Since morphine has been shown to significantly depress cellular metabolism, we examined its effect on these and other reparative responses underlyin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)91010-2
更新日期:1979-10-19 00:00:00
abstract::Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P anal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)00362-4
更新日期:1997-06-06 00:00:00
abstract::Using the teased fiber recording method, we have compared pathophysiological properties of afferent axons injured in the infraorbital nerve (ION) vs the sciatic nerve in rats. Both myelinated and unmyelinated axons ending in ION neuromas produced much less ongoing discharge than those ending in sciatic nerve neuromas....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90753-v
更新日期:1992-05-01 00:00:00
abstract::Using nerve growth factor (NGF), anti-NGF sera and dissociated neonatal mouse dorsal root ganglionic neurons we present a microculture assay methodology for (1) the titration of neurotrophic factor (NTF) activity in monolayer culture, (2) the titration of NTF antibodies which 'block' NTF biological activity, (3) the t...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90408-x
更新日期:1981-12-28 00:00:00
abstract::Hippocampal corticosteroid receptors are regulated by corticosterone as well as by neurotransmitters, such as serotonin (5-HT). Studies have demonstrated that long-term changes in 5-HT levels are associated with alterations in hippocampal glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) number. However...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00371-v
更新日期:1995-06-26 00:00:00
abstract::Quantitative in vitro autoradiography was used to examine [3H]D-Ala2, MePhe4, Gly-015 enkephalin (DAGO) (mu-agonist) and [3H]diprenorphine (general opiate antagonist) binding sites in the hippocampal formation of young (6-8 months) and aged (25-28 months) Long-Evans rats. Age-related changes in these binding sites wer...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)01211-7
更新日期:1996-01-22 00:00:00
abstract::By using immunocytochemistry we tested whether neurotransmitters, and enzymes specific to neurotransmitters synthesis are rhythmically expressed in the suprachiasmatic nuclei of the hypothalamus of Ruin lizards Podarcis sicula either kept in light-dark cycles or constant darkness. Within the suprachiasmatic nuclei, pr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02567-8
更新日期:2003-05-23 00:00:00
abstract::Studies of various strains of mice revealed marked differences in their analgesic sensitivity towards morphine (mu), U50,488H (kappa 1) and naloxone benzoylhydrazone (NalBzoH; kappa 3). Sensitivity to mu and kappa analgesia varied independently of the other. Analgesic sensitivity to morphine remained relatively consis...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91712-a
更新日期:1991-12-06 00:00:00
abstract::Neurons in the polymorph layer of the hippocampal dentate hilus were found to be the cells of origin for ipsilateral association and commissural projections to the dentate gyrus. Both afferent systems terminate in the proximal one-third of the stratum moleculare. The polymorph layer is the primary target for noradrene...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90512-6
更新日期:1981-06-29 00:00:00