Vagus nerve stimulation produces a hippocampal formation theta rhythm in anesthetized rats.

Abstract:

:Vagus nerve stimulation (VNS) has been used for years to treat patients with drug-resistant epilepsy. In the present study, the effect of different stimulation protocols of VNS on the hippocampal formation (HPC) type II theta field potentials were evaluated in anesthetized rats. The following theta parameters were analysed: power, frequency and duration of theta epochs. We documented for the first time the presence of HPC type II theta in response to the application of VNS. A VNS-induced theta rhythm appeared in different experimental protocols and, depending on the current intensity, could occur directly during VNS (brief effect) or after vagal stimulation (delayed effect), using lower intensity stimuli.

journal_name

Brain Res

journal_title

Brain research

authors

Broncel A,Bocian R,Kłos-Wojtczak P,Konopacki J

doi

10.1016/j.brainres.2017.08.030

subject

Has Abstract

pub_date

2017-11-15 00:00:00

pages

41-50

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(17)30374-8

journal_volume

1675

pub_type

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