Abstract：
:In many persons with temporal lobe epilepsy, dentate granule cells form an interconnected synaptic network. This recurrent mossy fiber circuit mediates reverberating excitation that may facilitate seizure propagation by synchronizing granule cell discharge. The involvement of specific glutamate receptors in granule cell epileptiform activity evoked by stimulating the mossy fibers was investigated with use of rat hippocampal slices superfused with bicuculline, with or without increasing [K+](o) to 6 mM. The occurrence of short-latency mossy fiber-evoked granule cell epileptiform activity in slices from pilocarpine-treated rats correlated with the presence and extent of recurrent mossy fiber growth. Blockade of AMPA receptors nearly abolished the orthodromic component of the response; subsequent antagonism of kainate receptors as well appeared to have no further action. Antagonism of NMDA receptors reduced the duration of epileptiform discharge, but increased the amplitude of population spikes within the evoked burst. Thus AMPA and NMDA, but perhaps not kainate, receptors play an important role in this type of epileptiform activity. Activation of type II metabotropic glutamate receptors, which inhibits the release of glutamate from mossy fiber boutons, reduced the magnitude of epileptiform discharge. This action was reversed by a partial agonist of these receptors. However, neither an agonist nor an antagonist of type III metabotropic glutamate receptors significantly altered the response. Considering the importance of synchronous granule cell discharge for seizure propagation from the entorhinal cortex to the hippocampus, agonists of type II metabotropic glutamate receptors may be useful in suppressing such discharge both experimentally and clinically.
journal_name
Brain Resjournal_title
Brain researchauthors
Okazaki MM,Nadler JVdoi
10.1016/s0006-8993(01)02824-4subject
Has Abstractpub_date
2001-10-05 00:00:00pages
58-69issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(01)02824-4journal_volume
915pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Clozapine therapy has been associated with a high degree of urinary disturbances. The purpose of this study is to examine the effect of clozapine on urodynamic parameters and on the activity of the external urethral sphincter in anesthetized rats. Single cystometrograms (CMG) were performed on urethane-anesthetized fe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02352-6
更新日期：2001-05-18 00:00:00
abstract：:Visual acuity was measured by determining the highest spatial acuity at which chickens aged 1-25 days jumped consistently to a physically supported grating instead of to an unsupported homogeneous field. In contrast to the gradual visual development found for kittens, monkeys, and humans, the chicken exhibits asymptot...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90967-7
更新日期：1981-05-04 00:00:00
abstract：:The syndrome of vacuous chewing movements (VCMs) in rats is similar in many respects to tardive dyskinesia (TD) in humans. Both syndromes are characterized by delayed onset of persistent orofacial dyskinesias in a sub-group of subjects chronically treated with neuroleptics. Using the rat model, we examined the role of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00196-6
更新日期：1998-06-15 00:00:00
abstract：:Intracisternal (i.c.) administration of the glutamate-receptor antagonist kynurenate to halothane-anesthetized rats (paralyzed, ventilated) produced an initial hypertension associated with an increase in lumbar sympathetic nerve discharge. Kynurenate (i.c.) blocked or greatly reduced all sympathetic reflexes investiga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91320-0
更新日期：1988-01-12 00:00:00
abstract：:The spatio-temporal characteristics of release of acetylcholinesterase from the in vivo substantia nigra can now be described using a chemiluminescent reaction. Electrical stimulation of the striatum caused an increase in release of acetylcholinesterase within the ipsilateral substantia nigra; however, this increase i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90128-5
更新日期：1989-12-25 00:00:00
abstract：:We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was de...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.097
更新日期：2005-04-25 00:00:00
abstract：:The central amygdaloid nucleus (CeA) receives projection from the parabrachial nucleus (PBN) gustatory neurons and descendingly projects to the PBN, and taste responses in the PBN are significantly affected by stimulation or lesion of the CeA. To examine whether the GABA receptors within the CeA are involved in this m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.08.068
更新日期：2004-11-26 00:00:00
abstract：:Blink movement metrics were studied in three alert cynomolgus monkeys using electromagnetic search coils attached to the eyelids bilaterally. Monkey blinks averaged approximately 24 degrees. Down-phase peak velocities were approximately twice those of the corresponding up phases. Most blinks were symmetrical with clos...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90869-o
更新日期：1993-04-23 00:00:00
abstract：:Brief force perturbations were applied 30-120 ms prior to onset of step-tracking forearm movements by normal humans. The perturbations altered the first agonist burst of the movement-related triphasic EMG pattern. Perturbations opposing the movement resulted in an increase in the magnitude of the late part of the firs...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)91224-5
更新日期：1981-09-14 00:00:00
abstract：:Brain activity was measured autoradiographically using [1-14C]octanoate (OCTO) as a fast functional tracer in rats receiving either saline, heroin or cocaine. Regional optical densities were normalized to a relative optical density index for comparisons of OCTO labeling between treatment groups. Heroin significantly i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91323-6
更新日期：1988-01-12 00:00:00
abstract：:Repeated exposure to stressful stimuli or psychostimulants increases sensitivity to the motoric effects of these drugs, i.e. behavioral sensitization. The objective of the present experiment was to determine the interaction between factors that modulate psychostimulant sensitivity, i.e. sex and circulating gonadal hor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91651-9
更新日期：1994-05-09 00:00:00
abstract：:Immunohistochemical and retrograde tracing techniques were combined to demonstrate the occurrence of displaced ganglion cells (DGCs) exhibiting substance P-like immunoreactivity (SP-LI) in the pigeon retina. Following injections of rhodamine-labeled latex microspheres into the nucleus of the basal optic root (accessor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91159-x
更新日期：1991-04-12 00:00:00
abstract：:Recent studies stressed the importance of comparing exemplars both for improving performance by artificial classifiers as well as for explaining human category-learning strategies. In this report we provide a theoretical analysis for the usability of exemplar comparison for category-learning. We distinguish between tw...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.079
更新日期：2008-08-15 00:00:00
abstract：:Epidemiological studies have shown that steroidal as well as non-steroidal anti-inflammatory drugs lower the risk of developing Alzheimer's Disease (AD). A suppressive effect of these anti-inflammatory drugs on local inflammatory events in AD brains has been suggested, however the mechanisms responsible are still unkn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01204-3
更新日期：1997-11-28 00:00:00
abstract：:The blockade of central histaminergic H(2) receptors has been reported to aggravate ischemic neuronal damage. Since excess release of excitatory neurotransmitters is closely related to ischemic neuronal damage, the effects of ranitidine on ischemic release of dopamine were investigated in gerbil striatum. Changes in t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03107-9
更新日期：2002-02-01 00:00:00
abstract：:Our previous work has demonstrated that 100-Hz electroacupuncture (EA) or 100-Hz transcutaneous electrical nerve stimulation (TENS) was very effective in ameliorating the morphine withdrawal syndrome in rats and humans. The mechanism was obscure. (1) Rats were made dependent on morphine by repeated morphine injections...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02069-7
更新日期：1999-12-18 00:00:00
abstract：:The present study sought to determine if axonal connectivity is established between 6-month-old neostriatal transplants and the host substantia nigra. Cell suspensions of fetal neostriatum were transplanted into the adult rat neostriatum lesioned previously by kainic acid. Horseradish peroxidase injections into the ip...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91256-0
更新日期：1989-01-09 00:00:00
abstract：:The effect of central and peripheral administration of a nitric oxide synthase inhibitor, N-nitro-L-arginine methyl ester (L-NAME), on morphine hyperthermia was studied in male Sprague-Dawley rats. The first series of experiments examined the effect of subcutaneous (s.c.) administration of L-NAME on the hyperthermia i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02025-x
更新日期：2001-03-16 00:00:00
abstract：:There is a strong link between cognitive impairment and depression, but up to date it is not clear whether cognitive impairment is 'cause' or 'consequence' of depression. Therefore, we here examined the effect of cognitive impairment induced by permanent occlusion of common carotid arteries, a model known as two-vesse...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.056
更新日期：2015-01-30 00:00:00
abstract：:Local circuit neurons in the human anterior thalamus (AT) were identified on the basis of glutamic acid decarboxylase immunoreactivity (GAD-IR). GAD-IR neurons of the AT displayed small diameter somas with thin, sparsely-branching dendrites, consistent with the morphological characteristics of local circuit neurons fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)03194-8
更新日期：2001-12-27 00:00:00
abstract：:Previous studies found that injection of the GABA uptake inhibitor nipecotic acid into the nucleus tractus solitarius (NTS) increases arterial pressure. This effect of nipecotic acid was not antagonized by the selective GABAA receptor blocking agent bicuculline, suggesting that the action of nipecotic acid was mediate...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91227-8
更新日期：1990-09-03 00:00:00
abstract：:Microinjection of a substance P analogue (1 mM; 7 or 10 nl) into laminae I and II of the L7 dorsal horn of decerebrate cats significantly potentiated (P < 0.05) the increase in arterial pressure evoked by microinjection of L-glutamate (109 mM; 7 or 10 nl) into these spinal sites. Microinjection of the substance P anal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00362-4
更新日期：1997-06-06 00:00:00
abstract：:From 4 or 5 postnatal days, rat pups were either reared by their mothers (MR) or artificially reared (AR) without their mothers by infusion of 'milk' through a gastric cannula. In AR, but not MR, pups the left eye was more likely to open first than the right eye (P less than 0.001). The left-biassed eye-opening of AR ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90073-8
更新日期：1986-07-01 00:00:00
abstract：:Exercise has been shown to influence learning and memory. Most studies were performed with a voluntary running paradigm (e.g. running wheel) in mice. However, such effects of exercise on learning and memory are less well demonstrated using a forced running paradigm (e.g. treadmill). The present study was designed to e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.07.023
更新日期：2006-10-03 00:00:00
abstract：:This study in lightly anesthetized rats found that unilateral electrical stimulation delivered to the ventral part of the thalamic nucleus submedius (Sm), the thalamic reuniens nucleus (Re) and the hypothalamic dorsal area (DA) markedly depressed the TF reflex, and this inhibitory effect increased following increasing...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00856-l
更新日期：1995-10-23 00:00:00
abstract：:Quantal analysis of transmitter release is useful in examining presynaptic mechanisms involved in synaptic transmission. However, in central neurons, the presence of multiple synapses makes it difficult to use the traditional quantal analysis, developed for the neuromuscular transmission. We developed a method to mini...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.056
更新日期：2008-05-01 00:00:00
abstract：:We measured the uptake of a radiolabeled analogue of glucose ([3H]FDG) into muscles during treadmill walking so as to determine whether sensory deafferentation of a limb affects the muscles' metabolic response to the exercise. The muscles on the deafferented side took up less tracer than those in the intact side with ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91526-4
更新日期：1985-02-18 00:00:00
abstract：:The effects of lesions in the pars compacta of the substantia nigra of 4-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY) were studied on (a) changes in blood pressure during a period of 6 weeks following lesioning, and (b) dopamine and metabolite concentrations in the caudate nu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91739-6
更新日期：1994-03-14 00:00:00
abstract：:Several regulated mRNAs were detected by applying differential display to the mouse cerebellum during postnatal development. One cDNA fragment, referred to as CPD1 (GenBank U89345), was characterized and cloned. Northern blots showed maximum mRNA expression at postnatal day seven (P7). The mRNA encodes a protein of 26...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02351-4
更新日期：2001-07-13 00:00:00
abstract：:Bombesin-like immunoreactivity occurs in a dense network of nerve fibres in the rat coeliac-superior mesenteric ganglion. No bombesin immunoreactive cell bodies have been observed in this ganglion. An origin outside the ganglion was therefore assumed for the bombesin immunoreactive fibres. Ligation of the mesenteric n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90981-2
更新日期：1983-06-13 00:00:00
