Abstract：
:Fasting induced a reduction in neuronal nitric oxide synthase (nNOS) mRNA in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) of rats. The effect of intracerebroventricular (i.c.v.) administration of leptin on the nNOS mRNA level in the PVN and SON of fasting rats was studied by in situ hybridization histochemistry. Leptin (10 microg/kg b.wt) or vehicle was administered i.c.v. at 1700 h on two successive days fasting for 2 days. Fasting for 2 days with i.c.v. administration of vehicle induced a significant reduction of nNOS mRNA in the PVN and SON. Central administration of leptin prevented the fasting-induced reduction of nNOS mRNA in the PVN and SON. Administration of leptin also prevented the fasting-induced reductions of thyrotropin-releasing hormone (TRH) and corticotropin-releasing hormone (CRH) mRNAs in the parvocellular division of the PVN. These results suggest that leptin is associated with fasting-induced reduction of nNOS mRNA in the PVN and SON as well as TRH and CRH mRNAs in the PVN.
journal_name
Brain Resjournal_title
Brain researchauthors
Isse T,Ueta Y,Serino R,Noguchi J,Yamamoto Y,Nomura M,Shibuya I,Lightman SL,Yamashita Hdoi
10.1016/s0006-8993(99)02065-xsubject
Has Abstractpub_date
1999-11-06 00:00:00pages
229-35issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(99)02065-Xjournal_volume
846pub_type
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