当前位置： SCI文献检索 > BRAIN RESEARCH期刊下所有文献 > Hypovolemia upregulates the expression of neuronal nitric oxide synthase gene in the paraventricular and supraoptic nuclei of rats.

Hypovolemia upregulates the expression of neuronal nitric oxide synthase gene in the paraventricular and supraoptic nuclei of rats.

Abstract：

:We have examined the effects of isotonic hypovolemia on the expression of the neuronal nitric oxide synthase (nNOS) gene in the paraventricular (PVN) and supraoptic nuclei (SON) of the rat, using in situ hybridization histochemistry with a 35S-labelled oligodeoxynucleotide probe complementary to nNOS mRNA. Intraperitoneal (i.p.) administration of polyethylene glycol (PEG) (MW 4000, 20 ml/kg body weight) dissolved in 0.9% saline (20% w/v) induced isotonic hypovolemia. The expression of the nNOS gene in the PVN and SON 6 h after i.p. administration of PEG was increased significantly in comparison with controls. The dual staining for NADPH diaphorase activity and Fos-like immunoreactivity (Fos-LI) showed that at 3 and 6 h after i.p. administration of PEG, a subpopulation of NADPH diaphorase-positive cells in the PVN and SON exhibited nuclear Fos-LI. These results suggest that NO in the PVN and SON may be involved in the neuroendocrine and autonomic responses to non-osmotic hypovolemia.

journal_name

Brain Res

journal_title

Brain research

authors

Ueta Y,Levy A,Lightman SL,Hara Y,Serino R,Nomura M,Shibuya I,Hattori Y,Yamashita H

doi

10.1016/s0006-8993(97)01531-x

subject

Has Abstract

pub_date

1998-04-20 00:00:00

pages

25-32

issue

1-2

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(97)01531-X

journal_volume

790

pub_type

杂志文章

相关文献

BRAIN RESEARCH文献大全
  • Spinal cord serotonin release and raised blood pressure after brainstem kainic acid injection.

    abstract：:The recently developed technique of in vivo dialysis has permitted us to make direct measurements of serotonin release in a specific region of the spinal cord and to relate this to changes in blood pressure elicited by chemical stimulation of the brainstem. In the present experiments we have shown that chemical stimul...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)91318-1

    authors： Pilowsky PM,Kapoor V,Minson JB,West MJ,Chalmers JP

    更新日期：1986-02-26 00:00:00

  • Electrophysiological analysis of factors involved in the primary demyelinating diseases: the rabbit eye model system.

    abstract：:This study explores the longitudinal assessment of visual evoked potentials (VEPs) in the rabbit as a method for defining factors underlying functional and structural changes associated with optic neuritis and the inflammatory demyelinating diseases. In rabbits with experimental autoimmune encephalomyelitis (EAE) indu...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)90557-4

    authors： Arezzo JC,Brosnan CF,Schroeder CE,Litwak MS,Bornstein MB

    更新日期：1988-10-18 00:00:00

  • Systemic 3-nitropropionic acid: long-term effects on locomotor behavior.

    abstract：:Systemic administration of 3-nitropropionic acid (3-NP) results in striatal atrophy by irreversibly inhibiting the citric acid cycle, and thereby resulting in cellular ATP depletion. The neuropathological outcome following 3-NP injections is thought to resemble that seen in Huntington's disease (HD) [1]. The current s...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)90085-x

    authors： Koutouzis TK,Borlongan CV,Scorcia T,Creese I,Cahill DW,Freeman TB,Sanberg PR

    更新日期：1994-05-23 00:00:00

  • The retrograde transport of horseradish peroxidase from the developing limb of the chick embryo.

    abstract：:Chick embryos ranging in age from 4.0 to 18 days of incubation and 1-2-day-old hatchlings received injections of HRP solutions directly into the leg musculature. After survival periods of from 5 to 25 h motoneurons and cells in the spinal sensory ganglia were found to be stained with the HRP reaction product. It was f...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(75)90007-4

    authors： Oppenheim RW,Heaton MB

    更新日期：1975-11-14 00:00:00

  • Essential roles of mitochondrial depolarization in neuron loss through microglial activation and attraction toward neurons.

    abstract：:As life spans increased, neurodegenerative disorders that affect aging populations have also increased. Progressive neuronal loss in specific brain regions is the most common cause of neurodegenerative disease; however, key determinants mediating neuron loss are not fully understood. Using a model of mitochondrial mem...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2013.02.005

    authors： Nam MK,Shin HA,Han JH,Park DW,Rhim H

    更新日期：2013-04-10 00:00:00

  • Increased binding at 5-HT(1A), 5-HT(1B), and 5-HT(2A) receptors and 5-HT transporters in diet-induced obese rats.

    abstract：:5-Hydroxytryptamine (5-HT, serotonin), synthesized in midbrain raphe nuclei and released in various hypothalamic sites, decreases food intake but the specific 5-HT receptor subtypes involved are controversial. Here, we have studied changes in the regional density of binding to 5-HT receptors and transporters and the l...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)02055-7

    authors： Park S,Harrold JA,Widdowson PS,Williams G

    更新日期：1999-11-13 00:00:00

  • Centrifugal fibers to the rat retina from the medial pretectal area and the periaqueductal grey matter.

    abstract：:Intraocular injections of several different retrograde tracers were made in albino rats. Retrogradely filled neurons were observed in two locations: the medial pretectal area and the contralateral periaqueductal grey matter, indicating that the pretectum and the mesencephalon are sources of centrifugal innervation to ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)90046-0

    authors： Itaya SK,Itaya PW

    更新日期：1985-02-11 00:00:00

  • Effects of chronic fenfluramine administration on hypothalamic neuropeptide mRNA expression.

    abstract：:Appetite suppressants lose efficacy when given chronically; the mechanisms are unknown. We gave male rats once-daily dl-fenfluramine (dl-FEN, 5 mg/kg, i.p.) injections for 15 days and measured mRNA expression of corticotropin releasing factor (CRF), neuropeptide Y (NPY) and proopiomelanocortin (POMC) in hypothalamic n...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.02.129

    authors： Choi S,Blake V,Cole S,Fernstrom JD

    更新日期：2006-05-04 00:00:00

  • Acute and chronic effects of neurotrophic factors BDNF and GDNF on responses mediated by thermo-sensitive TRP channels in cultured rat dorsal root ganglion neurons.

    abstract：:Neurotrophic factors (NTFs), beside regulating neuronal survival in the central and peripheral nervous system, are also involved in the modulation of neuronal function in the adult animal. Both brain-derived neurotrophic factor (BDNF) and glial cell-derived neurotrophic factor (GDNF) levels are altered in pathological...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2009.06.014

    authors： Ciobanu C,Reid G,Babes A

    更新日期：2009-08-11 00:00:00

  • Effect of olfactory bulb kindling on evoked potentials in the pyriform cortex.

    abstract：:The potential evoked in the pyriform cortex by single-pulse stimulation of the olfactory bulb was examined before and after single and repeated elicitation of an epileptiform afterdischarge produced by stimulation of the olfactory bulb. A single afterdischarge (AD) produced a rapid (i.e. within 5 min) increase in the ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)91275-2

    authors： Russell RD,Stripling JS

    更新日期：1985-12-30 00:00:00

  • Distribution of histaminergic, muscarinic and serotonergic binding sites in cat spinal cord with emphasis on the region surrounding the central canal.

    abstract：:[3H]Quinuclidinyl benzilate (QNB), [3H]lysergic acid diethylamide (LSD) and [3H]pyrilamine were used with radiohistochemistry to determine the distribution of muscarinic, serotonergic and histaminergic binding sites, respectively, in cat spinal cord. Each ligand displayed a unique pattern of binding sites in the super...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(85)91128-x

    authors： Seybold VS

    更新日期：1985-09-09 00:00:00

  • High density of cholinergic muscarinic receptors accompanies high intensity acetylcholinesterase-staining in layer IV of infant rat somatosensory cortex.

    abstract：:In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0165-3806(83)90018-4

    authors： Kristt DA,Kasper EK

    更新日期：1983-06-01 00:00:00

  • Age- and gender-related metabonomic alterations in striatum and cerebellar cortex in rats.

    abstract：:In order to identify the neurochemical alterations in motor associated subcortical nuclei, and enhance our understanding of neurophysiology of progressive reduction in fine motor control with aging, the metabolic changes in striatum and cerebellar cortex in SD rats along with aging were investigated using a metabonomi...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2013.02.033

    authors： Zhang X,Wu J,Liu H,Zhang X

    更新日期：2013-04-24 00:00:00

  • Inhibition of long-term potentiation of the hippocampal CA1 EPSP by a negative cooperativity.

    abstract：:Tetanization of commissural-CA1 input to the apical dendrites of the dorsal hippocampal CA1 area was found to produce a marked long-term potentiation of the field EPSP. Whereas by concurrent tetanization of the commissural pathway and medial septo-CA1 input, this potentiation was significantly reduced. Thus a negative...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(88)91201-2

    authors： Xie XP

    更新日期：1988-04-05 00:00:00

  • Direct projections from caudal ventrolateral medullary depressor sites to the subfornical organ.

    abstract：:Experiments were performed in the male Wistar rat to investigate the projections from cardiovascular responsive sites in the ventrolateral medulla (VLM) to the subfornical organ (SFO). Unilateral iontophoretic injections of Phaseolus vulgaris leucoagglutinin (PHA-L) were made into either caudal VLM (CVLM) sites at whi...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2003.12.029

    authors： Babic T,Roder S,Ciriello J

    更新日期：2004-04-02 00:00:00

  • Synergistic interactions of endogenous opioids and cannabinoid systems.

    abstract：:Cannabinoids and opioids are distinct drug classes historically used in combination to treat pain. Delta(9)-THC, an active constituent in marijuana, releases endogenous dynorphin A and leucine enkephalin in the production of analgesia. The endocannabinoid, anandamide (AEA), fails to release dynorphin A. The synthetic ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(99)01908-3

    authors： Welch SP,Eads M

    更新日期：1999-11-27 00:00:00

  • Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry.

    abstract：:The effects of a wide range of doses of systemically administered cysteamine were studied on locomotor behavior, passive avoidance memory, cortical and cerebrospinal fluid somatostatin-like immunoactivity and cortical levels of dopamine and norepinephrine. High doses of cysteamine (200 and 250 mg/kg s.c.) led to susta...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(87)90060-6

    authors： Haroutunian V,Mantin R,Campbell GA,Tsuboyama GK,Davis KL

    更新日期：1987-02-17 00:00:00

  • Lectin affinity and PAGE analysis of soluble axonally transported glycoconjugates in the rat visual system.

    abstract：:Recent reports of the transsynaptic transfer of wheat germ agglutinin (WGA) in several systems are consistent with the hypothesis that WGA binds to endogenous glycoproteins(s) which undergo transsynaptic transfer. Such molecules might be involved in trophic interactions between neurons. Since these hypothetical glycop...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(86)90599-8

    authors： Rhodes CH,Gonatas NK

    更新日期：1986-12-03 00:00:00

  • Hippocampal sympathetic ingrowth and cholinergic denervation uniquely alter muscarinic receptor subtypes in the hippocampus.

    abstract：:Following cholinergic denervation of the hippocampus by medial septal lesions, and unusual neuronal reorganization occurs, in which peripheral sympathetic fibers, originating from the superior cervical ganglia, grow into the hippocampus. Previously, we have found that both hippocampal sympathetic ingrowth (HSI) and ch...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(95)00070-7

    authors： Harrell LE,Kolasa K,Parsons DS,Ayyagari V

    更新日期：1995-04-10 00:00:00

  • Neurochemical and morphological changes during the development of cobalt-induced epilepsy in the rat.

    abstract：:Following the implantation of cobalt-gelatine pellets into the frontal cortex, epileptiform spikes in both primary and secondary foci developed and reached a peak between 7-12 days post implantation. Histological examination showed a necrotic lesion with terminal and fibre degeneration in brain areas connected with th...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(75)90288-7

    authors： Emson PC,Joseph MH

    更新日期：1975-07-25 00:00:00

  • Neurokinin-1 receptors and spinal cord control of blood pressure in spontaneously hypertensive rats.

    abstract：:In this study we examined blood pressure and heart rate responses to intrathecal administration of a synthetic NK1-receptor agonist, H2N-(CH2)4-CO-Phe-Phe-Pro-NmeLeu-Met-NH2 (GR 73,632), in spontaneously hypertensive rats (SHR) and their progenitor strain, the Wistar-Kyoto rat (WKY). Sodium pentobarbitone anaesthetise...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/s0006-8993(98)01107-x

    authors： Solomon SG,Llewellyn-Smith IJ,Minson JB,Arnolda LF,Chalmers JP,Pilowsky PM

    更新日期：1999-01-02 00:00:00

  • Penicillin-induced epileptic phenomena in the rabbit's neocortex II. Laminar specific generation of interictal spikes after the application of penicillin to different cortical depths.

    abstract：:To elucidate the generation mechanisms of interictal spikes we analyzed the electrical events in the different layers of the rabbit's neocortex after application of penicillin to distinct cortical layers. Field potentials (FP) recorded simultaneously from all layers with a 16-fold micro-electrode-assembly were subject...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：

    authors： Pockberger H,Rappelsberger P,Petsche H

    更新日期：1984-09-10 00:00:00

  • 'Real-motion' cells in the primary visual cortex of macaque monkeys.

    abstract：:Extracellular recordings were carried out in the primary visual cortex of behaving macaque monkeys. Neurons were activated by moving a visual stimulus across their receptive fields during periods of steady fixation and by moving their receptive fields (by visual tracking) across a motionless visual stimulus, taking ca...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(84)90406-2

    authors： Galletti C,Squatrito S,Battaglini PP,Grazia Maioli M

    更新日期：1984-05-28 00:00:00

  • Gene expression of serotonin and dopamine receptors and monoamine oxidase-A in the brain of dominant and subordinate pubertal domestic pigs (Sus scrofa) fed a β-adrenoreceptor agonist.

    abstract：:Aggression is a major source of social stress with negative effects on health and well-being, yet limited information is known about the molecular mechanisms mediating aggressive behavior in swine. Ractopamine (RAC) is a β-adrenoreceptor agonist that enhances growth but increases aggressive behaviors in female pigs. T...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2010.11.035

    authors： Poletto R,Cheng HW,Meisel RL,Richert BT,Marchant-Forde JN

    更新日期：2011-03-24 00:00:00

  • CA1 ischemic injury does not affect the ability of Mongolian gerbils to solve response, direction, or place problems.

    abstract：:Open field and T-maze paradigms are used to test the effects of hippocampal lesions on spatial memory in rodents. Place cells in the dorsal CA1 region of the hippocampus are known to be responsible for the formation of global place maps, while CA3 neurons respond to changes in local contexts. It is proposed here that ...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2007.10.050

    authors： Walsh SJ,Harley CW,Corbett D,Skinner DM,Martin GM

    更新日期：2008-01-02 00:00:00

  • Differential antinociceptive effects of sendide, a NK1-receptor antagonist, and morphine in the capsaicin test.

    abstract：:The peptide NK1-receptor antagonists, sendide and [D-Trp7]sendide, have been evaluated for antinociceptive activity in the capsaicin test. Both peptides, injected intrathecally (i.t.) 5 min prior to intraplantar capsaicin, produced a dose-dependent reduction of the capsaicin-induced paw licking response. Naloxone (4.0...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(94)91080-4

    authors： Sakurada T,Yogo H,Katsumata K,Tan-No K,Sakurada S,Kisara K,Ohba M

    更新日期：1994-06-27 00:00:00

  • Regional and cellular localisation of Parkin co-regulated gene in developing and adult mouse brain.

    abstract：:Parkin Co-Regulated Gene (PACRG) is a novel gene that is oriented in a head-to-head array with parkin, and expression of the two genes is regulated by a shared bi-directional promoter. Mutations in parkin are the most common cause of early-onset autosomal recessive Parkinson's disease, however the function of PACRG an...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2008.01.050

    authors： Brody KM,Taylor JM,Wilson GR,Delatycki MB,Lockhart PJ

    更新日期：2008-03-27 00:00:00

  • The human lateral tuberal nucleus: Immunohistochemical characterization and analogy to the rodent PV1-nucleus.

    abstract：:The lateral tuberal nucleus (LTN) is a hypothalamic region that has been identified with certainty only in humans and primates. It is composed of three small round globular units which protrude the basal surface of the brain along the optic tract. The function of the LTN is unknown. Recently, a tiny, parvalbumin-posit...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/j.brainres.2006.12.093

    authors： Gerig AT,Celio MR

    更新日期：2007-03-30 00:00:00

  • Expression of c-fos protein by immunohistochemically identified oxytocin neurons in the rat hypothalamus upon osmotic stimulation.

    abstract：:Double immunostaining for c-fos and oxytocin (OXY) was used to study the topography and time course of the metabolic activation of the hypothalamic oxytocinergic system upon osmotic stress in the male rat. Animals injected i.p. with hypertonic saline expressed c-fos-like immunoreactivity (FLI) in the paraventricular (...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(92)91342-c

    authors： Giovannelli L,Shiromani PJ,Jirikowski GF,Bloom FE

    更新日期：1992-08-14 00:00:00

  • A linked active transport system for Na+ and K+ in a glial cell line.

    abstract：:Ouabain (5 X 10(-4) M) induced a 6-fold increase in intracellular Na+ and a 65% loss of cellular K+ in C6 glial cells which was accompanied by a 12 mV decrease in the resting membrane potential. Following ouabain washout intracellular ion concentrations and the membrane potential returned to control levels suggesting...

    journal_title：Brain research

    pub_type： 杂志文章

    doi：10.1016/0006-8993(76)90649-1

    authors： Kukes G,De Vellis J,Elul R

    更新日期：1976-03-05 00:00:00