Abstract：
:Growth of cultured N1E-115 neuroblastoma cells in 1 microM A23187 for 2 days to elevate internal Ca reduced both membrane Na current and the transient, but not steady state, component of outward K current. Na channel mRNA abundance was reduced by an average value of 45% without effect on Kv3.1. Increases in internal Ca may therefore control excitability by independent regulation of Na and K channel mRNA abundance in neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Hirsh JK,Quandt FNdoi
10.1016/0006-8993(95)01340-7subject
Has Abstractpub_date
1996-01-15 00:00:00pages
343-6issue
2eissn
0006-8993issn
1872-6240pii
0006899395013407journal_volume
706pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Nutrients in the intestine inhibit food intake via an action on the vagal afferent pathway. The aim of the present study was to use immunochemical detection of Fos protein-like immunoreactivity (FLI) in the brainstem to trace the neuronal pathways activated by intestinal nutrients. Perfusion of the intestine of awake ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91272-6
更新日期：1994-11-14 00:00:00
abstract：:The effects of divalent and trivalent cations on the gamma-aminobutyric acid (GABA)-induced chloride current were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell configuration of the patch-clamp technique. Lanthanum (La3+) reversibly potentiated the GABA-induced current with a hal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91510-y
更新日期：1993-04-02 00:00:00
abstract：:We have previously shown that the HSV-2 anti-apoptotic protein ICP10PK is delivered by the replication incompetent virus mutant DeltaRR and prevents kainic acid (KA)-induced epileptiform seizures and neuronal cell loss in the mouse and rat models of temporal lobe epilepsy. The present studies used DeltaRR and the ICP1...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.078
更新日期：2006-11-13 00:00:00
abstract：:The goal of the present study was to identify the projection from the subdivisions of the amygdaloid nuclear complex to specified subregions of the dorsal raphe (DR) nucleus and to attempt to compare the density of amygdaloid input to the DR with that of inputs from other limbic structures. Use of a retrograde tracer,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.081
更新日期：2007-04-27 00:00:00
abstract：:Cholinergic systems modulate synaptic transmission across the neuraxis and play an important role in higher brain function including cognition, arousal and nociception. The anterior cingulate cortex (ACC) is a fundamental brain region for nociception and chronic pain, and receives cholinergic projections mainly from b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2018.10.013
更新日期：2019-02-01 00:00:00
abstract：:Neurite formation in neurones isolated from adult molluscs in culture has been shown to depend on the total content of Ca in the cells, intracellular Ca2+ concentration, intracellular acid-alkaline balance, extracellular pH, and the capacity and composition of buffers. The neurones with a low total Ca content prior to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90546-2
更新日期：1983-10-03 00:00:00
abstract：:The potential evoked in the pyriform cortex by single-pulse stimulation of the olfactory bulb was examined before and after single and repeated elicitation of an epileptiform afterdischarge produced by stimulation of the olfactory bulb. A single afterdischarge (AD) produced a rapid (i.e. within 5 min) increase in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91275-2
更新日期：1985-12-30 00:00:00
abstract：:Diphtheria toxin (DTX) kills cells by inactivating ribosomal translocation and when used to retrogradely intoxicate cat intercostal motoneurones produces marked morphological alterations in Nissl bodies, including those specifically sited postsynaptic to C-type axon terminals. Here, qualitative examinations of 'intoxi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90302-r
更新日期：1990-02-12 00:00:00
abstract：OBJECTIVE:To investigate the effect of salvinorin A (SA) on brain injury and neurologic function post-brain ischemia/reperfusion (I/R) using a rat forebrain ischemia model and further explore the effect of kappa opioid receptor (KOR) inhibition by SA on aquaporin-4 (AQP4) expression in the hippocampus, cortex and stria...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.024
更新日期：2016-04-15 00:00:00
abstract：:Peripheral input to lamina VIII interneurones was investigated by using extracellular and/or intracellular records from them. The interneurones were located in the L4-L5 spinal segments and projected to contralateral motor nuclei in the L7 segment. They constituted a non-homogeneous population but their input from mus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91618-q
更新日期：1990-12-10 00:00:00
abstract：:To elucidate the intracellular mechanism of the bursting activity which is characteristic of seizure discharge, the behavior of the intracellular cyclic nucleotide and the intracellular calcium during pentylenetetrazole (PTZ)-induced bursting activity in snail neurons was investigated. Cyclic AMP was increased about 3...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90137-3
更新日期：1983-06-20 00:00:00
abstract：:The hypothesis according to which BoTx and TeTx block neuromuscular transmission by impairing Ca2+ influx was tested by recording presynaptic membrane currents at motor endplates of the mouse by means of external electrodes. The use of K-channel blockers allowed us to observe inward Ca current which was unaffected by ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90617-0
更新日期：1983-07-04 00:00:00
abstract：:Long-term potentiation (LTP) has received considerable attention as a neurophysiological model for studying the biology of memory. The present experiments examined the susceptibility of LTP in the dentate gyrus to modification by peripheral injections of amphetamine and epinephrine. Both drugs enhanced the development...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91124-7
更新日期：1984-07-02 00:00:00
abstract：:Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.009
更新日期：2006-02-16 00:00:00
abstract：:We previously observed that substance P (SP) levels in the rat superior cervical ganglion (SCG) rise sharply when the ganglion is maintained in vitro. To define the cellular localization of SP, sections of cultured SCG were stained for the possible dual presence of SP and tyrosine hydroxylase (TOH). Immunoreactivity t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91442-2
更新日期：1984-04-30 00:00:00
abstract：:Tetanic but not low frequency stimulation of the perforant path in rat hippocampal slices results in changes in the metabolism of phosphoinositides and phosphatidic acid. The phosphorylation of other, non-inositol lipids was not affected by the high frequency stimulation. The observed changes in phosphoinositide metab...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90198-7
更新日期：1984-11-12 00:00:00
abstract：:Primary cultures of astrocytes exhibit a polygonal morphology, but on treatment with agents that increase cAMP they change to stellate cells. We found that astrocyte stellation also occurred on replacing the culture medium with saline buffered with HEPES. However, stellation did not occur when the medium was replaced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02819-6
更新日期：2002-08-09 00:00:00
abstract：:The rate and pattern of seizure development provoked by repeated electrical stimulation of the amygdala (kindling) was assessed in rats that had been pretreated with intracerebral injections of the selective catecholaminergic neurotoxin 6-hydroxy-dopamine. Rats with selective depletion of forebrain noradrenaline displ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90289-9
更新日期：1980-05-26 00:00:00
abstract：:An in vitro preparation of the medulla oblongata of the rat was used to examine the responses to reducing pH, at constant CO2, of neurons in several identified nuclei. Neurons in an area close to the ventral surface, which is thought to be the location of pH-sensitive central respiratory chemoreceptors, did not respon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90300-1
更新日期：1983-07-25 00:00:00
abstract：:The transcription factor Phox2b is necessary for the development of the nucleus of the solitary tract (NTS). In this brainstem nucleus, Phox2b is expressed exclusively within a subpopulation of glutamatergic neurons. The present experiments in the adult rat were designed to test whether this subpopulation includes the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.072
更新日期：2008-08-21 00:00:00
abstract：:Pregnenolone sulfate (PS) is an endogenous neurosteroid known to antagonize GABA(A) receptor-mediated inhibitory responses and potentiate NMDA receptor-mediated excitatory responses in vitro. To assess the actions of the steroid as a modulator of seizure susceptibility in vivo, PS (30-300 nmol) was administered intrac...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01287-1
更新日期：1999-06-12 00:00:00
abstract：:The biosynthetic activity of extra-hypothalamic vasopressin (VP) neurons in the bed nucleus of the stria terminalis (BNST) is regulated by gonadal steroids. These neurons have also been implicated in a number of behaviors that are impaired in aging. We previously reported that VP mRNA labelling in the BNST is decrease...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(10)80030-7
更新日期：1992-06-26 00:00:00
abstract：:The responses of spinocervical neurons to sinusoidal hair displacements were studied during and in the absence of radiant heating of parts of the hindpaw to noxious levels (45-65 degrees C). Noxious heat usually increased background discharge and lowered the signal-to-noise ratio at low frequencies of hair displacemen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90949-5
更新日期：1981-10-05 00:00:00
abstract：:The purpose of this study was to determine the ultrastructure of the blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) in G93A SOD1 mice modeling ALS at different stages of disease. Electron microscope examination of brainstem, cervical and lumbar spinal cords was performed in ALS mice at early and late s...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.04.044
更新日期：2007-07-09 00:00:00
abstract：:Morphological and physiological effects of kainic acid (KA) lesions in rat ventral lateral geniculate nucleus (LGV) were studied 1.5 and 6 h after KA injection. Morphological changes were examined mainly by electron micrographs. At 1.5 h after KA injection dendrites were dilated and some vacuolations occurred in both ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90033-4
更新日期：1989-03-27 00:00:00
abstract：:An experiment was performed in order to determine the role of the amygdala and surrounding cortex in quiet biting attack elicited from electrical stimulation of the hypothalamus. Stimulation of basal, cortical, and anterior amygdala as well as pyriform cortex and parahippocampal gyrus resulted in a suppression of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90433-3
更新日期：1980-09-15 00:00:00
abstract：:Aluminum (Al) is among the most abundant elements on earth, it has been associated with the etiology of Alzheimer's disease. In the present study, AlCl(3) was administered with the dose of 10, 50 or 300 mg/kg b.wt/day through diet for 100 days. On day 101, overnight-fasted animals were sacrificed, the whole brains wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.02.024
更新日期：2010-04-09 00:00:00
abstract：:Nestin is an intermediate filament protein, transiently and abundantly expressed early in embryogenesis, e.g., in neuroepithelial cells, radial glia, germinal matrix cells and vascular cells. In the adult rat brain, nestin is only present in endothelial and select subventricular cells. We tested the hypothesis that af...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01502-4
更新日期：1999-08-14 00:00:00
abstract：:Previous studies showed that hyperbaric oxygen (HBO) promoted cell proliferation in hypoxic-ischemic (HI) neonate rats. Neural stem cells (NSC) existed in the brain lifelong and can be activated. This study was undertaken to assess whether HBO treatment promoted the proliferation of NSC and repaired the brain damage r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.05.016
更新日期：2008-07-30 00:00:00
abstract：:The lateral hypothalamus (LH) is a site of integration for control mechanisms of feeding behavior as it has extensive reciprocal connections with multiple intrahypothalamic and extrahypothalamic brain areas. Evidence suggests that blockade of ionotropric gamma-aminobutyric acid (GABA) receptors in the LH elicits eatin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.05.064
更新日期：2009-08-04 00:00:00
