Abstract：
:Nutrients in the intestine inhibit food intake via an action on the vagal afferent pathway. The aim of the present study was to use immunochemical detection of Fos protein-like immunoreactivity (FLI) in the brainstem to trace the neuronal pathways activated by intestinal nutrients. Perfusion of the intestine of awake rats via an indwelling duodenal catheter with iso-osmotic mannitol, hydrochloric acid or casein hydrolysate had no effect on the number of FLI neurons in the nucleus of the solitary tract (NTS). Lipid emulsion (20%) and 2.7 M glucose significantly increased the number of immunopositive cells in the NTS. There was a significant increase in the number of immunopositive cells from caudal to rostral NTS. Nutrients effective at decreasing food intake (carbohydrate and fat) produced significant increases in Fos-like immunopositive cells in the NTS.
journal_name
Brain Resjournal_title
Brain researchauthors
Zittel TT,De Giorgio R,Sternini C,Raybould HEdoi
10.1016/0006-8993(94)91272-6subject
Has Abstractpub_date
1994-11-14 00:00:00pages
266-70issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91272-6journal_volume
663pub_type
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