Abstract：
:(1) Input conductances of giant interneurons in the isolated spinal cord of lampreys were measured with two separate intracellular electrodes. Bath applications of 0.4--3 mM beta-alanine and taurine produced large, reversible conductance increases which were Cl-dependent. (2) Strychnine at 1--2.5 microM might be a competitive antagonist of both amino acids, but had a stronger effect on taurine. Bicuculline and picrotoxin were weak antagonists of beta-alanine and taurine in some cells. (3) A few giant interneurons desensitized after repeated application of the amino acids, but most became more sensitive. Responses to the amino acids also increase at low temperatures in in Na-free fluid, suggesting effect of uptake mechanisms.
journal_name
Brain Resjournal_title
Brain researchauthors
Homma Sdoi
10.1016/0006-8993(79)90628-0subject
Has Abstractpub_date
1979-09-14 00:00:00pages
287-93issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(79)90628-0journal_volume
173pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Chronic total sleep deprivation (TSD) of rats by the disk-over-water method reliably produces initial increases and subsequent decreases in waking intraperitoneal (Tip) and hypothalamic (Thy) temperatures, progressive increases in energy expenditure, skin lesions on the tail and plantar surfaces, debilitated appearanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)01071-8
更新日期：1995-12-12 00:00:00
abstract：:Choroid plexuses from the lateral (LVCP) and fourth ventricles (FVCP) of rats or rabbits were incubated in artificial cerebrospinal fluid (CSF) containing 1 microM [14C]L-carnitine with various concentrations of L-carnitine ranging from 0.01 mM to 1.0 mM. The time course of 1 microM [14C]L-carnitine uptake by the chor...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90188-2
更新日期：1991-07-19 00:00:00
abstract：:Climbing fiber responses (CFRs) evoked by white matter stimulation and parallel fiber responses (PFRs) elicited by the stimulation of the surface of the folium were compared using intracellular recording from the dendrites of Purkinje cells in the in vitro slice preparation of the guinea pig cerebellum. Intracellular ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90439-1
更新日期：1985-12-02 00:00:00
abstract：:GEC1 protein shares high identity with GABARAP (GABA(A) Receptor-Associated Protein), interacts with tubulin and GABA(A) receptors and is potentially involved in intracellular transport processes. Recently, using quantitative real time PCR, we have reported the gec1 mRNA expression in different rat brain areas. In the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.077
更新日期：2008-05-19 00:00:00
abstract：:We examined the effect of the peripheral application of glutamate and capsaicin to the temporomandibular joint (TMJ) in influencing the activation and central sensitization of TMJ-responsive nociceptive neurons in the trigeminal subnucleus caudalis/upper cervical cord (Vc/UCC). The activity of single neurons activated...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.056
更新日期：2009-02-09 00:00:00
abstract：:Intracellular assessments of the physiological actions of cannabinoid receptor agonists and antagonists on adult hippocampal CA1 pyramidal cells in the in vitro slice preparation were performed using current clamp and conventional sharp-electrode intracellular recording procedures. Several manipulations were performed...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02110-7
更新日期：2000-04-28 00:00:00
abstract：:Trigeminal hyperalgesia frequently appears in diabetic neuralgia altering the transmission of orofacial sensory information. This study was designed to explore the effects of trigeminal hyperalgesia in streptozotocin-induced diabetes monitoring the expression of nitric oxide synthase in the trigeminal ganglion cells. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02235-6
更新日期：2000-05-19 00:00:00
abstract：:We reported earlier that overnight change in explicit memory is positively related to the change in sleep spindle activity (between a control and a learning night). However, it remained unclear whether this effect was restricted to good memory performers and whether a general association of sleep spindles and a "sleep...
journal_title：Brain research
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.brainres.2007.10.106
更新日期：2008-01-29 00:00:00
abstract：:A search for vasomotor depressor sites in the lateral medullary brainstem of anesthetized cat using microinjections of AMPA has delineated a longitudinal column of sympathoinhibitory neurons consisting of the rostral depressor area, the caudal ventrolateral medulla, and a new intermediate depressor area. Systematic bl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91257-s
更新日期：1993-02-19 00:00:00
abstract：:Vanadate (VO-3), an essential trace element with insulin-mimetic actions, produces systemic hyperglycemia following central administration in mice. The hyperglycemic effect is due to specific action of vanadate or its reduced form, vanadyl (VO2+); other ions of similar atomic weight (Cr, Mn) or structure (phosphate) h...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90615-9
更新日期：1987-09-01 00:00:00
abstract：:It is now well known that dopamine (DA) receptors agonists can reduce striatal DA release. These compounds are generally thought to produce short-term effects. However, in a recent in vivo study we have reported that the D1/D2 receptor agonist apomorphine might induce decrements in striatal DA release that lasted seve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90922-9
更新日期：1994-04-11 00:00:00
abstract：:After a moderate global cerebral ischemia, two hypothetical populations of pyramidal neurons are present among the hippocampal CA1 pyramidal neurons: one that will die and another one that will survive. Prior analysis of dissected hippocampal CA1 regions has shown a reduction of the GluR1-3 mRNA following ischemia. In...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)01985-0
更新日期：2001-03-09 00:00:00
abstract：:The default mode network (DMN) is characterised by coherent very low frequency (VLF) neural oscillations in the resting brain. The attenuation of this activity has been demonstrated following the transition from rest to performance of a broad range of cognitive goal-directed tasks. Whether the activity of resting stat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.05.043
更新日期：2013-08-02 00:00:00
abstract：:The prostacyclin (PGI2) formation in cerebral vessels, as reflected by the difference in concentration of internal carotid arterial and internal jugular venous radioimmunoassayed 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), was determined under normocapnic and hypercapnic conditions in 5 patients with mild cereb...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91272-6
更新日期：1983-01-24 00:00:00
abstract：:The primary objective of this study was to test the hypothesis that intravenous administration of autologous bone marrow cells could improve functional recovery after middle cerebral artery occlusion (MCAO) for 45 min in the rat and to determine specific time windows for efficacy. Mononuclear cells from autologous bon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.09.084
更新日期：2004-05-08 00:00:00
abstract：:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90488-9
更新日期：1986-04-09 00:00:00
abstract：:A review of the available literature reveals that proliferation of ependyma occurs during embryological and early postnatal periods of development. Turnover, however, declines significantly during postnatal life and only low levels of residual activity persist into adulthood under normal conditions. In some regions of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/0165-0173(85)90016-5
更新日期：1985-04-01 00:00:00
abstract：:Three different estrogen receptors (ERs) have been characterized in teleost fish, i.e. Esr1, Esr2a and Esr2b. In this study we carried out in situ hybridizations in the brain and pituitary of the sea bass (Dicentrarchus labrax) to study the putative involvement of Esr2 subtypes in the control of gonadotropin secretion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.053
更新日期：2008-05-19 00:00:00
abstract：:The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90977-4
更新日期：1991-05-03 00:00:00
abstract：:The neurons that produce gonadotrophin-releasing hormone (GnRH) are mainly found in the medial preoptic area (MPOA) and constitute a common final pathway to the control of luteinizing hormone (LH) surge on proestrus. The control of GnRH secretion depends on several neurotransmitters, such as serotonin (5-HT), noradren...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.045
更新日期：2007-04-20 00:00:00
abstract：:We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01472-9
更新日期：1999-06-12 00:00:00
abstract：:The neuroprotective effect of tachykinins against excitotoxic death of cholinergic neurons was studied in rat striatal cell cultures. Quinolinic acid (QUIN) and kainic acid (KA) produced a dose dependent decrease in choline acetyltransferase activity, but KA was more potent. Our results show that substance P (SP) tota...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00879-7
更新日期：1996-11-18 00:00:00
abstract：:Veratridine-induced depolarization caused a large increase in Ca uptake in the rat hippocampal slice (30.2 vs. 9.0 nM/mg dry weight). This uptake was reduced to 18.4 nM/mg when veratridine was combined with anoxia. When compared with veratridine exposure alone, the combination of anoxia and veratridine increased intra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91547-4
更新日期：1994-01-07 00:00:00
abstract：:Kinins, a special class of polypeptides, are represented by bradykinin (BK), kallidin (Lys-BK), as well as their metabolites. The biological actions of these polypeptides binding on their receptors (B1 and B2) have been related to inflammation process, cytokines action, glutamate release and prostaglandins production....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.12.050
更新日期：2004-04-23 00:00:00
abstract：:Traumatic brain injury (TBI) in humans typically produces neurological suppression and a longer lasting impairment of memory clinically defined as post-traumatic amnesia. An animal model that reliably reproduces the physiological changes associated with TBI was used to assess the memory deficits following brain injury...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91014-j
更新日期：1993-06-18 00:00:00
abstract：:Pathophysiological responses to peripheral nerve injury include alterations in the activity, intrinsic membrane properties and excitability of spinal neurons. The intrinsic excitability of α-motoneurons is controlled in part by the expression, regulation, and distribution of membrane-bound ion channels. Ion channels, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.12.012
更新日期：2014-02-14 00:00:00
abstract：:Distribution and time course of the occurrence of "dark" neurons were compared with the EEG activity and behavior of rats during 4-aminopyridine (4-AP) induced epileptic seizures. A crystal of the K(+) channel blocker 4-AP (0.5 mg/kg) was placed onto the exposed parieto-occipital cortex of Halothane-anesthetized rats ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.06.044
更新日期：2008-09-04 00:00:00
abstract：:Neuronal degeneration was detected in the tenia tecta and other regions of the anterior limbic system of male weanling rats 3 days after four doses of 5 mg/kg d-amphetamine (4 x 5 mg/kg AMPH) when seizures occurred during AMPH exposure. Neurodegeneration in the parietal cortex, loss of tyrosine hydroxylase immunoreact...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02925-5
更新日期：2000-12-08 00:00:00
abstract：:The possibility of retinotopic organization of pathways of retinal fibers within the optic tract and the tectum of the frog was studied by selective labeling of the retinal fibers with horseradish peroxidase. Within the optic tract the pathways of the ventral, temporal and dorsal retinal fibers were ordered from the d...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90097-4
更新日期：1981-02-09 00:00:00
abstract：:Purkinje cell degeneration (pcd) mutant mice lose virtually all Purkinje cells. It was found that the pcd mutants did not show within-sessions habituation in terms of hole-poking responses. This type of perseverative responding has been found in rats with limbic system damage and implies a role for the cerebellum in b...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91354-1
更新日期：1989-02-06 00:00:00
