Abstract：
:The immunosuppressive macrolide FK-506 has been shown to protect neurons in culture against glutamate excitotoxicity. This effect was attributed to the binding of immunosuppressants to calcineurin-inhibiting immunophilins. We now report that also the non-immunosuppressive macrolide antibiotics protect neurons in culture against NMDA- but not kainate-mediated excitotoxicity. The effect was structure-dependent: larger macrolide rings were more active. Macrolides did not affect the 3-(2-carboxypiperazin-4yl)-propyl-1-phosphonic acid (CPP) binding or the NMDA-mediated calcium influx.
journal_name
Brain Resjournal_title
Brain researchauthors
Manev H,Favaron M,Candeo P,Fadda E,Lipartiti M,Milani Ddoi
10.1016/0006-8993(93)90098-8subject
Has Abstractpub_date
1993-10-08 00:00:00pages
331-5issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(93)90098-8journal_volume
624pub_type
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