Abstract：
:Amino acid uptake by slices of brain is greatly diminished by incubation of the slices in glucose-free media. Uptake can be restored by the addition of a number of substrates, e.g., lactate, citrate, or oxaloacetate. The mixture of succinate, malate, and pyruvate (SMP, 20, 5, and mM) restored amino acid uptake better than glucose after brain slices were incubated in glucose-free media to deplete endogenous energy stores. The degree of restoration of uptake was different with the various amino acid transport classes and was independent of the restoration of ATP levels in the tissue. After restoration of uptake with SMP the amino acid uptake was resistant to NaF, but was markedly more sensitive to arsenite and oligomycin. The results indicate the coupling of mitochondrial energy transducing systems to transport.
journal_name
Brain Resjournal_title
Brain researchauthors
Teller DN,Bana-Schwartz M,Deguzman T,Lajtha Adoi
10.1016/0006-8993(77)90524-8subject
Has Abstractpub_date
1977-08-12 00:00:00pages
321-34issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(77)90524-8journal_volume
131pub_type
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