Abstract：
:The ability of neutral red to serve as an internal pH indicator in biological systems was tested in the rat brain after parenteral adminstration of the dye. The injected dye is avidly taken up by the brain cells and is distributed mainly in intracellular organelles. The ratio of optical signals recorded from the frozen brain at 445 and 530 nm and compared with calibration curves provides pH values. Color transition of neutral red ranges from 6.0 to 8.0 pH units. Topographic application of this method is particularly useful in studying local pH changes in brains with developing ischemic foci.
journal_name
Brain Resjournal_title
Brain researchauthors
Kogure K,Alonso OF,Martinez Edoi
10.1016/0006-8993(80)90869-0subject
Has Abstractpub_date
1980-08-11 00:00:00pages
95-109issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(80)90869-0journal_volume
195pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Intracerebroventricular administration into sedentary mice of the high molecular mass fraction of cerebrospinal fluid (CSF) from exercise-exhausted rats produced a decrease in spontaneous motor activity [K. Inoue, H. Yamazaki, Y. Manabe, C. Fukuda, T. Fushiki, Release of a substance that suppresses spontaneous motor a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01966-6
更新日期：1999-11-06 00:00:00
abstract：:Mice were treated with dopamine (DA) receptor agonist and antagonist drugs: Agonists: (+/-)-SKF 38393 ((+/-)-1-phenyl-2,3,4, 5-tetrahydro-(1H)-3-benzazepine-7,8-diol) [DA D1-like]; bromocriptine, [DA D2 selective]; quinpirole, [DA D2/D3 preferring]; (+/-)-7-hydroxy-dipropylamino-tetralin (7-OH-DPAT), [DA D3/D2 preferr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01395-5
更新日期：1999-06-05 00:00:00
abstract：:The response of neurons in the preoptic and adjacent regions of the brain to intracarotid injection of hyperosmotic solutions was studied in 22 anesthetized cats. NaCl (0.5 M) caused a brisk acceleration of frequency lasting over 100 s in 120 of 207 units (58%). Glucose (2 M) and sucrose (2 M) had similar but smaller ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91026-1
更新日期：1985-10-21 00:00:00
abstract：:Subnanomolar concentrations of melatonin inhibit cyclic AMP and cyclic GMP accumulation in neonatal rat anterior pituitary stimulated in vitro with luteinizing-hormone releasing-hormone. Melatonin also inhibited forskolin-stimulated cyclic AMP accumulation in pars tuberalis. Inhibition of cyclic AMP accumulation is sp...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90129-7
更新日期：1989-12-25 00:00:00
abstract：:It has been confirmed that gabapentin (GBP) induced a inhibition of the voltage-gated persistent sodium current in chronically compressed dorsal root ganglion (DRG) neurons. The persistent sodium current is found in excitable DRG neurons of painful diabetic neuropathy (PDN) rats where it is mediated by tetrodotoxin (T...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.11.032
更新日期：2013-02-01 00:00:00
abstract：:Previous findings from this laboratory demonstrating changes in dopamine (DA) transporter and D2 receptors in the amygdaloid complex of subjects with major depression indicate that disruption of dopamine neurotransmission to the amygdala may contribute to behavioral symptoms associated with depression. Quantitative re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.009
更新日期：2008-05-01 00:00:00
abstract：:Low concentrations of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) enhanced neuronal and glial survival and/or differentiation in dissociated cultures of 14-day mouse embryo brain. Posttrial intracisternal injection into the brains of mice undergoing active avoidance training alleviated amn...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90807-9
更新日期：1987-03-17 00:00:00
abstract：:Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90721-7
更新日期：1983-09-12 00:00:00
abstract：:We previously showed that local striatal injections of malonate produce age-dependent excitotoxic lesions. In the present study volumetric analysis confirmed that malonate produces age-dependent striatal lesions. Pretreatment with the non-competitive and competitive NMDA receptor antagonists, MK-801 and LY274614, and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91412-5
更新日期：1994-05-30 00:00:00
abstract：:The neurophysiological correlates of autoinhibition at the terminals of nigrostriatal dopaminergic neurons were studied by measuring the changes in antidromic excitability of nigrostriatal neurons following local infusions of various catecholamine agonists and antagonists into the neostriatum. Infusions of apomorphine...
journal_title：Brain research
pub_type： 杂志文章
doi：
更新日期：1984-09-10 00:00:00
abstract：:In the adult brain, γ-amino butyric acid (GABA) is an inhibitory neurotransmitter, whereas it acts as an excitatory transmitter in the immature brain, and may be involved in morphogenesis. In the present study, we immunohistochemically examined the developmental changes in GABA signaling in the embryonic mouse cervica...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.10.003
更新日期：2012-11-27 00:00:00
abstract：:Malignant glioma cells maintain an elevated intracellular pH (pH(i)) within hypoxic-ischemic tumor microenvironments through persistent activation of sodium-proton transport (McLean et al., 2000). Amiloride has been reported to selectively kill human malignant glioma cell lines but not primary astrocytes (Hegde et al....
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.09.059
更新日期：2010-12-02 00:00:00
abstract：:Brain and anterior pituitary growth hormone (GH), thyroid-stimulating hormone (TSH) and luteinizing hormone (LH) were measured during fetal, neonatal, and pubertal life and into adulthood. Immunoassayable GH and TSH could be found in the fetal whole brain before their detection in the fetal pituitary. Developmental pa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90186-9
更新日期：1982-08-01 00:00:00
abstract：:Previous studies have clearly shown that the progressive decrease of growth hormone (GH) secretion occurring during ageing is coupled with a reduced responsiveness of pituitary GHRH receptors both in terms of GH secretion and activation of the adenylyl cyclase (AC), in the presence of increased basal values of the enz...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90340-9
更新日期：1994-04-25 00:00:00
abstract：:The understanding of sentences involves not only the retrieval of the meaning of single words, but the identification of the relation between a verb and its arguments. The way the brain manages to process word meaning and syntactic relations during language comprehension on-line still is a matter of debate. Here we re...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2006.08.038
更新日期：2007-05-18 00:00:00
abstract：:Quantitative in situ hybridization histochemistry was used to compare the effects of AMPH administration on mRNAs coding for zif/268, a member of the zinc finger family of immediate early genes, and the opioid peptides, preprodynorphin (PPD) and preproenkephalin (PPE), in rat striatum after 3 dosing schedules: (1) acu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01422-e
更新日期：1995-03-06 00:00:00
abstract：:We have monitored the expression of c-fos protein in the medulla oblongata of the ferret, using immunocytochemistry, to identify the brainstem pathways involved in the mediation of nausea and vomiting caused by the antineoplastic drug cisplatin. Cisplatin administration resulted in c-fos-like immunoreactivity (FLI) in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91654-j
更新日期：1991-11-29 00:00:00
abstract：:Nuclear factor κB (NFκB) signaling plays ubiquitous roles in inflammation, immune response and neurogenesis. G protein-coupled receptor kinase 5 (GRK5) can protect neurons from degeneration. GRK5 also mediates tumor necrosis factor-α (TNFα)-induced NFκB signaling through the phosphorylation of IκBα. Here, we show that...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2015.02.041
更新日期：2015-05-22 00:00:00
abstract：:The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90800-o
更新日期：1992-03-06 00:00:00
abstract：:A normobar hypoxia (9% oxygen) of 8 h reduces the neurotoxicity of a subcutaneous injection of 10 mg/kg kainic acid given one week later. Both seizures and degenerative changes, including cell death of hippocampal and cortical neurons are markedly decreased by hypoxia. It is also shown that hypoxia also markedly reduc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91693-4
更新日期：1994-05-02 00:00:00
abstract：:Male Fischer-344 rats were injected i.p. with diethyldithiocarbamate or dithizone 15 min after kainic acid (KA), s.c. Diethyldithiocarbamate and dithizone reduced both the number of wet dog shakes and the latency to onset of seizures induced by KA. Moreover, they increased the severity of seizures. These compounds may...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91273-j
更新日期：1990-01-08 00:00:00
abstract：:The effects of the imidazothienodiazepinone Ro 19-4603 were investigated in mice. Ro 19-4603 (0.03-0.3 mg/kg) caused a dose-related reduction in seizure threshold to i.v. bicuculline. Doses of 0.1-3 mg/kg induced seizures in some but not all mice, consistent with its suggested action as a partial benzodiazepine recept...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90551-9
更新日期：1989-03-13 00:00:00
abstract：:A combined retrograde transport-immunohistochemical method was used to compare the numbers of corticotropin-releasing factor (CRF) and vasopressin-immunoreactive neurons in the paraventricular nucleus of the hypothalamus (PVH) that could be retrogradely labeled after tracer injections in the dorsomedial medulla or the...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91641-6
更新日期：1987-12-29 00:00:00
abstract：OBJECTIVE:To investigate the effect of salvinorin A (SA) on brain injury and neurologic function post-brain ischemia/reperfusion (I/R) using a rat forebrain ischemia model and further explore the effect of kappa opioid receptor (KOR) inhibition by SA on aquaporin-4 (AQP4) expression in the hippocampus, cortex and stria...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.02.024
更新日期：2016-04-15 00:00:00
abstract：:Three priming injections with the D1/D2 dopamine agonist apomorphine permits a challenge with the D2 agonist quinpirole to elicit robust contralateral rotation and ipsilateral striatal Fos expression in 6-hydroxydopamine lesioned rats. Pretreatment with NMDA glutamate antagonists MK-801 or CPP dose-dependently attenua...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02086-8
更新日期：2001-04-06 00:00:00
abstract：:The neurotoxic effects of amyloid-beta(1-42) and amyloid-beta(25-35) (A beta) on cholinergic and acetylcholinesterase-positive neurons were investigated in primary cultures derived from embryonic 18-day-old rat basal forebrain. After various time intervals, the cultures were treated with 1, 5, 10 or 20 microM A beta f...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2003.11.021
更新日期：2004-02-13 00:00:00
abstract：:Bilateral intraventricular injections of 6-hydroxydopamine depleted dopamine (DA) in striatal tissue of rats by 88%. Tail shock increased DA in striatal extracellular fluid of these rats from 10 to 17 pg/20 microliters as measured by microdialysis, values less than half those seen in normal striatum. The increase was ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91158-d
更新日期：1990-09-17 00:00:00
abstract：:Adolescence is a critical period for neurodevelopment. In the present study, we investigated the effects of peri-adolescent social isolation on latent inhibition (LI) and dopamine D2 receptor expression in the medial prefrontal cortex (mPFC) and nucleus accumbens (NAc) of young adult rats. Male Sprague-Dawley rats wer...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.01.058
更新日期：2012-04-04 00:00:00
abstract：:Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91232-7
更新日期：1994-02-21 00:00:00
abstract：:Our recent results showed that angiotensin II or III (AII, AIII) microinjected into the zona incerta (ZI) significantly increased water intake. The most effective doses of AII and AIII were also defined. The two neuropeptides had their effects differently on drinking via different receptors. AII bound to AT(1) that wa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.002
更新日期：2004-03-26 00:00:00
