Abstract：
:Porcine calcitonin (pCT) encapsulated in sulfatide-containing reverse-phase evaporation vesicles (REVs) was shown to induce long-lasting and dose-dependent antinociceptive effect by systemic injection in mice. Its antinociceptive activity is found to be dependent on the route of administration. In contrast, neither unencapsulated pCT nor pCT encapsulated in sulfatide-free REVs was effective. These results suggest that pCT entrapped in sulfatide-containing liposomes might be able to cross the blood-brain barrier (BBB) and to produce central antinociception in mice.
journal_name
Brain Resjournal_title
Brain researchauthors
Chen D,Li QT,Lee KHdoi
10.1016/0006-8993(93)91311-fsubject
Has Abstractpub_date
1993-02-12 00:00:00pages
139-42issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(93)91311-Fjournal_volume
603pub_type
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