Abstract：
:Intracerebroventricular injection of mast-cell degranulating peptide (MCD), dendrotoxin I (DTXI) and 4-aminopyridine (4-AP), 3 blockers of a subclass of K+ channel, produces seizures and convulsions. Three different K+ channel openers are potent blockers of MCD-induced hyperexicitatory effects when they are administered preventively but they are unable to inhibit the epileptogenic effects induced by DTXI and 4-AP which were thought to block the same K+ channel which is blocked by MCD.
journal_name
Brain Resjournal_title
Brain researchauthors
Gandolfo G,Gottesmann C,Bidard JN,Lazdunski Mdoi
10.1016/0006-8993(89)91236-5subject
Has Abstractpub_date
1989-08-21 00:00:00pages
189-92issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)91236-5journal_volume
495pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Prairie voles are socially monogamous mammals that form pair bonds and display paternal care. This study was focused on the male prairie vole's neuronal responses to infant-related odors. Using the fos protein as a measure of neuronal activation, we examined the brain responses of males to infant-related odors. Prior ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.02.023
更新日期：2019-07-01 00:00:00
abstract：:Recent studies, which have shown an increase of plasma vasopressin (VP) in experimental motion sickness and the efficacy of VP antagonists for motion sickness, suggest an important role of VP in the development of vestibulo-autonomic responses. We have recently found evidence of the co-existence of vasopressinergic ne...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02799-8
更新日期：2001-09-28 00:00:00
abstract：:The distribution of 125I-melatonin binding sites in 6 discrete brain regions of female rats at the estrous stage and the effects of ovariectomy and subsequent 17 beta-estradiol treatment on these binding sites were studied. Specific binding of 125I-melatonin was found in the hypothalamus, medulla-pons, hippocampus, ce...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91057-2
更新日期：1987-01-27 00:00:00
abstract：:In urodele amphibians, the hypothalamic neuropeptide arginine vasotocin and the adrenal steroid corticosterone interact to regulate reproductive behavior by actions in the brain. The present study investigated signal transduction pathways underlying acute effects of vasotocin and corticosterone, presumably mediated vi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.11.071
更新日期：2007-02-23 00:00:00
abstract：:Myelin, the lipid-rich sheath that insulates axons to facilitate rapid conduction of action potentials, is an evolutionary innovation of the jawed-vertebrate lineage. Research efforts aimed at understanding the molecular mechanisms governing myelination have primarily focused on rodent models; however, with the advent...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2015.10.011
更新日期：2016-06-15 00:00:00
abstract：:Symbolic visual cues indicating the location of an upcoming target are believed to invoke endogenous shifts of attention to cued locations. In the present study, we investigated how visual attention is shifted during such cuing paradigms by recording event-related potentials (ERPs). We focused on a component known to ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.011
更新日期：2009-11-10 00:00:00
abstract：:Chick pineal cells contain a circadian oscillator that derives rhythmic synthesis and secretion of melatonin even in dispersed cell culture. Here, we demonstrate that the mRNA encoding tryptophan hydroxylase (TPH), the first enzyme in the melatonin synthetic pathway, is expressed rhythmically under the control of the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00743-3
更新日期：1996-10-28 00:00:00
abstract：:Analgesia can be elicited following microinjections of morphine, mu-selective agonists and beta-endorphin into the amygdala. These analgesic responses are mediated by opioid synapses in the periaqueductal gray (PAG) since general (naltrexone), mu (beta-funaltrexamine) and delta2 (naltrindole isothiocyanate) opioid ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01115-3
更新日期：1998-01-01 00:00:00
abstract：:In vivo proton magnetic resonance spectroscopy was used to investigate intracerebral phenylalanine (Phe) concentrations in nine patients with classical phenylketonuria (PKU). The study included serial examinations (n = 31; plasma Phe levels: 0.47-2.24 mmol/l) of patients either receiving a Phe-restricted diet (200 mg ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01054-8
更新日期：1997-12-19 00:00:00
abstract：:The development of hypertension in spontaneously hypertensive rats (SHR) and hyperactive voiding in rats with urethral obstruction are characterized by abnormal smooth muscle growth, increased tissue levels of nerve growth factor (NGF) and altered patterns of innervation. The present study was undertaken to determine ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00061-4
更新日期：1998-04-20 00:00:00
abstract：:Infusion of 15 micrograms/microliters (approximately 120 micrograms/kg/h) of indomethacin within the ventral septal area of the rat brain significantly reduced a centrally induced prostaglandin E1 (PGE1) hyperthermia when compared with infusions of artificial cerebrospinal fluid. A bolus injection of a V1 receptor ant...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)90599-4
更新日期：1989-08-14 00:00:00
abstract：:We evaluated the effects of glycine exposure upon CA1-evoked response in the rat hippocampal slice. Exposure to 10 mM glycine for 16 min produced rapid neuronal firing and increased orthodromic population spike (PS), followed by loss of CA1 neural transmission. Upon recovery, CA1 orthodromic and antidromic PS regained...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91961-5
更新日期：1994-11-21 00:00:00
abstract：:Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glyco...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91197-x
更新日期：1980-01-27 00:00:00
abstract：:In this study the laminar localization of binding sites for the muscarinic radioligand [3H]3-quinuclidinylbenzilate was studied in somatosensory cortex of infant rat. Using light autoradiographic techniques, [3H]QNB was found to be concentrated in layer IV. Atropine-pretreated pups showed evenly dispersed, nonspecific...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90018-4
更新日期：1983-06-01 00:00:00
abstract：:Double-pulse stimulation of the perforant path input to the dentate gyrus was used in the following experiments to produce paired pulse depression in that site. This effect provided an estimate of GABA-mediated recurrent inhibition. The depression was enhanced by drugs that facilitate or mimic GABA action and attenuat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90909-5
更新日期：1983-10-24 00:00:00
abstract：:Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01064-1
更新日期：1999-03-06 00:00:00
abstract：:Potassium-evoked cholecystokinin (CCK) release from slices of caudate-putamen and cerebral cortex, but not hippocampus incubated in vitro was increased by 152-175% by preincubation for 40 min with 10 mM lithium. These results and previous studies suggest that although different physiological agents regulate CCK releas...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91030-4
更新日期：1987-06-16 00:00:00
abstract：:An indirect method of immunocytochemistry showed that cholera toxin and its B-subunit served as specific neuronal surface markers in conjunction with monoclonal anti-cholera toxin and FITC labeled anti-mouse Fab. The cell types which get specifically stained in culture were peripheral neurons from dorsal root ganglion...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90305-5
更新日期：1982-06-24 00:00:00
abstract：:The effect of somatostatin on muscarinic receptors (mAchR) was investigated through saturation experiments of [3H]oxotremorine-M-acetate and oxotremorine/[3H]N-methyl-scopolamine competition experiments. Somatostatin converted oxotremorine high affinity binding sites to low affinity sites in the hippocampus and cerebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90879-6
更新日期：1986-07-09 00:00:00
abstract：:Opioid peptides and their receptors have been localized to the inner ear of the rat and guinea pig mammalian models. The expression of mu opioid receptor (MOR) in the human and mouse cochlea is not yet known. We present MOR protein localization by immunohistochemistry and mRNA expression by in situ hybridization in th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.051
更新日期：2014-11-24 00:00:00
abstract：:Sokoloff's [14C]2-deoxyglucose method has been applied to investigate circadian variations in local cerebral glucose utilization (LCGU). Freely moving rats were tested during two phases of the circadian light/dark cycle. In the rats tested during darkness, elevations in LCGU, when compared with animals tested during t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91460-1
更新日期：1989-12-29 00:00:00
abstract：:The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding label...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90850-3
更新日期：1984-05-23 00:00:00
abstract：:The studies were performed on operation material from 17- to 63-year-old patients and on fetuses at 19-23 weeks gestational age. Formaldehyde histofluorescence showed the presence of numerous perivascular adrenergic nerves around pial and intracerebral vessels, the carotid system being better supplied than the vertebr...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(76)90356-5
更新日期：1976-10-22 00:00:00
abstract：:Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA receptor antagonist bicuculline or a glycine receptor antagonist strychnine (100 microM each), separately, restore...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.066
更新日期：2005-05-10 00:00:00
abstract：:Thalamocortical connections were studied after injections of retrograde tracers were made into rostral or caudal parts of cortical area Fr2 in adult rats. The data reveal that both rostral Fr2 (rFr2) and caudal Fr2 (cFr2) receive input from the centrolateral, central medial, interanteromedial, mediodorsal, paracentral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91420-6
更新日期：1991-12-24 00:00:00
abstract：:Mitochondria critically regulate cytoplasmic Ca(2+) concentration ([Ca(2+)]c), but the effects of sensory neuron injury have not been examined. Using FCCP (1µM) to eliminate mitochondrial Ca(2+) uptake combined with oligomycin (10µM) to prevent ATP depletion, we first identified features of depolarization-induced neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2014.09.040
更新日期：2014-11-17 00:00:00
abstract：:Chronic-intermittent hypoxia (CIH) was postulated to evoke c-fos expression in cortical regions that modulate sympathetic discharge. Animals exposed to CIH for 30 days exhibited c-fos labeling in medial prefrontal, cingulate, retrosplenial, and insular cortices. Our findings strongly suggest activation of cortical cir...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02170-3
更新日期：2000-07-07 00:00:00
abstract：:Whole-cell patch-clamp recordings were undertaken to characterize and compare the membrane properties of deep dorsal horn neurons in transverse slices of rat lumbar spinal cord in two age groups, postnatal days (P) 3-6 and 9-16. In both age groups, significant correlations were observed between membrane time constant ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00578-7
更新日期：1997-09-05 00:00:00
abstract：:In the rat, calbindin-like immunoreactivity was observed at both the light and electron microscopic levels within the chemoreceptor neurons of the vomeronasal organ (VNO) and both intragemmal cells and associated nerve fibers of the circumvallate taste buds. All VNO neurons were immunoreactive. Only a subset of intrag...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90493-s
更新日期：1992-02-14 00:00:00
abstract：:Brain edema (BE) is an uncommon but life-threatening complication of severe diabetic ketoacidosis (DKA) and its treatment. Despite advances in treatment of DKA, the pathogenesis of both initiation and progression of the associated BE is unclear. In the present study we examined the blood brain barrier (BBB) integrity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.100
更新日期：2009-02-13 00:00:00
