Abstract：
:Previously, we had shown that ammonium chloride (ammonia)-induced accumulation of cyclic GMP in the microdialysates of rat striatum is blocked by taurine. In this study, coinfusion with taurine of a GABAA receptor antagonist bicuculline or a glycine receptor antagonist strychnine (100 microM each), separately, restored ammonia-induced release of cGMP to the extracellular fluid to approximately 29% and 18% of the level measured in the absence of taurine, respectively. Simultaneous coinfusion of both antagonists or of 100 muM picrotoxin, which is an antagonist of both GABAA and Gly receptors, offsets most of the taurine block. Ammonia-induced accumulation of cyclic GMP was attenuated by approximately 12% upon coinfusion of a GABAA receptor agonist muscimol (100 microM). The results suggest that stimulation of both GABAA and glycine receptors is involved in the mechanism by which taurine limits the activation of the NMDA/NO/cGMP pathway by ammonia in the striatum.
journal_name
Brain Resjournal_title
Brain researchauthors
Hilgier W,Oja SS,Saransaari P,Albrecht Jdoi
10.1016/j.brainres.2005.02.066subject
Has Abstractpub_date
2005-05-10 00:00:00pages
242-6issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)00356-2journal_volume
1043pub_type
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