Abstract:
:The dentato-olivary projection has been ultrastructurally studied in rats that received a wheatgerm agglutinin-horseradish peroxidase (WGA-HRP) injection in the nucleus lateralis. Ultrathin sections containing the inferior olive have been double-labelled with the GABA-immunogold method. About 97% of the WGA-HRP labelled axon terminals are GABA-immunopositive. Most of them belong to a single type consisting of small boutons establishing symmetrical synapses on dendrites. Nevertheless, there is some morphological and neurochemical diversity among the labelled terminals, and particularly, a small contingent are GABA-immunonegative. Of the GABAergic dentato-olivary boutons, 4% occupy a privileged position, with synaptic contacts straddling two dendritic profiles linked by gap junctions. The strategic location of these inhibitory dentato-olivary synapses suggests that they can modulate the electrotonic coupling rate between sets of inferior olivary neurons.
journal_name
Brain Resjournal_title
Brain researchauthors
Angaut P,Sotelo Cdoi
10.1016/0006-8993(89)91641-7subject
Has Abstractpub_date
1989-02-13 00:00:00pages
361-5issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(89)91641-7journal_volume
479pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::In order to explore the anatomical nature of the inhibitory GABAergic control of cerebral serotonergic neurons exerted at the level of the anterior raphé cells in the rat, we have studied the effect of GABA agonist agents (given systemically or infused locally into the raphé dorsalis or medianus) on cerebral 5-hydroxy...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90717-6
更新日期:1985-04-01 00:00:00
abstract::The insula has emerged as a critical target for electrical stimulation since it influences pathological pain states. We investigated the effects of repetitive electrical stimulation of the insular cortex (ESI) on mechanical nociception, and general locomotor activity in rats subjected to chronic constriction injury (C...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147237
更新日期:2021-01-02 00:00:00
abstract::Thyrotropin-releasing hormone (TRH)-like immunoreactivity was examined in the rat olfactory bulb by an immunohistochemical method using antiserum against the tripeptide TRH. TRH-immunoreactive neurons and neuronal processes were localized in both main and accessory olfactory bulb, including the glomerular layer, exter...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90983-3
更新日期:1988-04-26 00:00:00
abstract::This experiment was conducted to determine if nigrostriatal dopamine (DA) neurons are necessary for the contraversive rotational behavior evoked by electrical stimulation in the lateral hypothalamus. Rats were tested daily for electrical stimulation-induced rotational behavior (ESRB) for 5 days, and then given an inje...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91508-2
更新日期:1985-02-18 00:00:00
abstract::Manipulations of either discrete emotions (e.g. happiness) or affective dimensions (e.g. positivity) have a long tradition in emotion research, but interactive effects have never been studied, based on the assumption that the two underlying theories are incompatible. Recent theorizing suggests, however, that the human...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.03.045
更新日期:2014-05-20 00:00:00
abstract::GABAA receptors (GABAARs) and glycine receptors (GlyRs) are two principal inhibitory chloride ion channels in the central nervous system. The two receptors do not function independently but cross-talk to each other, i.e., the activation of one receptor would inhibit the other. This cross-talk is present in different p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147071
更新日期:2020-12-01 00:00:00
abstract::The electric activities of cortical pyramidal neurons are supported by structurally stable, morphologically complex axo-dendritic trees. Anatomical differences between axons and dendrites in regard to their length or caliber reflect the underlying functional specializations, for input or output of neural information, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2020.147069
更新日期:2020-12-01 00:00:00
abstract::An immunoneutralization technique with specific antibodies was used to explore the role of endogenous neuropeptide Y (NPY) in the adrenocorticotropic hormone (ACTH) release after hypoglycemic stress in the dog. Dogs received injections of rabbit antihuman NPY gamma-globulin (anti-NPY) or normal gamma-globulin (NGG) in...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91369-r
更新日期:1990-03-05 00:00:00
abstract::Simultaneous extracellular recordings from one electrode of 'local' groups of 3-6 neurons were obtained from the auditory cortex of unanesthetized, paralyzed cats. The activity and functional connectivity of local microenvironments were examined under various auditory stimuli. Single cell response patterns were examin...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90567-x
更新日期:1983-08-08 00:00:00
abstract::The impact of perinatal exposure to environmental tobacco smoke (ETS) on cognitive development is controversial. We exposed rhesus monkeys to ETS or filtered air (5 animals per group) beginning in utero on day 50 of pregnancy and continuing throughout postnatal testing. In infancy, we evaluated both groups for visual ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.03.001
更新日期:2007-06-02 00:00:00
abstract::The effect of suprachiasmatic nucleus (SCN) ablation on rhythms in brain neurotransmitter receptors was studied. In control animals, the rhythms in the number of alpha-adrenergic and benzodiazepine receptors were circadian, whereas the rhythms in beta-adrenergic and acetylcholine receptors were ultradian. SCN ablation...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91533-1
更新日期:1985-02-18 00:00:00
abstract::The present study attempts to elucidate the possible role of adenosine 3',5'-monophosphate (cAMP) and prostaglandin E2 (PGE2) in the function of the neural luteinizing hormone-releasing hormone (LH-RH) apparatus. To this end, in vitro LH-RH release from superfused hypothalamic fragments and cAMP production by hypothal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)90162-9
更新日期:1986-10-29 00:00:00
abstract::Event-related potentials (ERP) were measured when pleasant, neutral or unpleasant pictures were presented in the context of similarly valenced stimuli, and compared to ERPs elicited when the same pictures were viewed in an intermixed context. An early ERP component (150-300 ms) measured over occipital and fronto-centr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.10.072
更新日期:2008-01-16 00:00:00
abstract::Transforming growth factor-beta 1 (TGF-beta 1) is highly expressed in neural tissues following brain injuries. To determine a role of TGF-beta 1 in neural pathologies, axons of cultured rat hippocampal neurons were cut by local irradiation of laser beam, and the effect of TGF-beta 1 on neurite regeneration following a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00253-3
更新日期:1996-06-03 00:00:00
abstract::The effects of lateral hypothalamic (LH) lesions were studied in golden-mantled ground squirrels, Spermophilus lateralis, a species of mammalian hibernator that displays endogenous circannual body weight cycles when kept in constant conditions. The lesions were made during the weight-gain phase. Evidence that the lesi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91518-0
更新日期:1986-12-10 00:00:00
abstract::Two high molecular weight surface glycoproteins of cerebellar cells which are selectively labeled by lactoperoxidase-catalyzed iodination of monolayer cultures from the developing mouse cerebellum, have been identified and partially characterised. Both molecules, called peak 2 and peak 3 proteins, were the major glyco...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91197-x
更新日期:1980-01-27 00:00:00
abstract::Diabetes mellitus (DM) may lead to gastrointestinal motility disorders. Rodent models of DM indicate the presence of morpho-functional abnormalities of the enteric nervous system. Here, we evaluated whether experimental DM can cause changes in the excitatory cholinergic fibers, neuronal density, and voltage-gated sodi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.11.041
更新日期:2019-04-01 00:00:00
abstract::Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)00904-3
更新日期:1996-11-25 00:00:00
abstract::Motor cortex stimulation (MCS) is a promising clinical procedure to help alleviate chronic pain. Animal models demonstrated that MCS is effective in lessening nocifensive behaviors. The present study explored the effects of MCS on cortical somatosensory evoked potentials (SEPs) recorded at the primary somatosensory co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.027
更新日期:2012-06-29 00:00:00
abstract::Deficits in experimentally induced drinking and pressor responses after administration of 6-hydroxydopamine (6-OHDA) into the lateral cerebral ventricle (LCV) have been reported. Questions have arisen, however, as to whether these effects are due to non-specific actions of the neurotoxin and, if specific, whether the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90128-4
更新日期:1987-02-10 00:00:00
abstract::The immunohistochemical distributions of tyrosine hydroxylase (TH), calmodulin (CaM) and calcium/CaM-dependent protein kinase II (CaMKII) in the rat forebrain were compared quantitatively to confirm our previous finding that TH activity and dopamine synthesis in the brain are regulated by a calcium/CaM-dependent syste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02271-0
更新日期:2002-04-12 00:00:00
abstract::Diffuse white matter (WM) response to traumatic brain injury (TBI) and transplantation of human bone marrow stromal cells (hMSCs) after the injury were non-invasively and dynamically investigated. Male Wistar rats (300-350 g) subjected to TBI were intravenously injected with 1 ml of saline (n = 10) or with hMSCs in su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.020
更新日期:2019-08-15 00:00:00
abstract::Medial basal hypothalamic (MBH) 5 alpha-reductase activity was significantly blocked with a known inhibitor, Proscar (Finasteride), in pregnant rats while their open-field behavior was quantified during the last week of pregnancy. In control animals, open-field behavior significantly decreased (in a stair-step fashion...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01068-2
更新日期:1996-11-11 00:00:00
abstract::Tetanization of commissural-CA1 input to the apical dendrites of the dorsal hippocampal CA1 area was found to produce a marked long-term potentiation of the field EPSP. Whereas by concurrent tetanization of the commissural pathway and medial septo-CA1 input, this potentiation was significantly reduced. Thus a negative...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)91201-2
更新日期:1988-04-05 00:00:00
abstract::The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91667-2
更新日期:1987-12-15 00:00:00
abstract::Poly(ADP-ribose) polymerase (PARP) can initiate an energy-consuming and inefficient repair cycle following cerebral ischemia/reperfusion by transferring ADP ribose units to nuclear proteins eventually leading to cellular dysfunction and neuronal death. 3-Aminobenzamide (3-AB) is a selective inhibitor of PARP that can ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02852-9
更新日期:2001-10-12 00:00:00
abstract::It has been previously established that the housing condition influences the appearance of the dendritic tree in young animals. The purpose of this investigation was to determine the extent of the influence that the housing condition exerts on morphometric studies involving old animals. Specifically, we found superfic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)91271-9
更新日期:1982-11-11 00:00:00
abstract::Alterations in protein phosphorylation may be important in the pathogenesis of Alzheimer's disease and recent observations suggest that a subset of protein kinase pathways may be selectively altered. Calcium/calmodulin-dependent protein kinase II CaM kinase II) is the most abundant protein kinase in the brain and is b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90979-2
更新日期:1994-09-19 00:00:00
abstract::Fulfilled predictions lead to neural suppression akin to repetition suppression, but it is currently unclear if such effects generalize to broader stimulus categories in the absence of exact expectations. In particular, does expecting novelty alter the way novel stimuli are processed? In the present study, the effects...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.008
更新日期:2018-09-01 00:00:00
abstract::The diagonal band of Broca (dbB) is involved in central cardiovascular control. In the present study we compared the effects of microinjections of L-glutamate into the dbB of unanesthetized rats with those observed after the injection of L-glutamate into the same area in urethane-anesthetized rats. The microinjection ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03769-1
更新日期:2003-01-10 00:00:00