Abstract：
:Simultaneous extracellular recordings from one electrode of 'local' groups of 3-6 neurons were obtained from the auditory cortex of unanesthetized, paralyzed cats. The activity and functional connectivity of local microenvironments were examined under various auditory stimuli. Single cell response patterns were examined using peri-stimulus (PST) histograms and functional connectivity among neighboring cells by the cross renewal density (CRD) histograms. Analysis of the PST histograms suggested that a high percentage of single cells demonstrated different response patterns to different stimuli. Analysis of the CRD histograms suggested, on the one hand, that only small numbers of neighboring cells behaved as if there were direct connections from one cell to another, and that these direct connections appeared to be excitatory. On the other hand, many cell pairs shared input from shared sources which lay outside the local groups. The majority of functional connections were altered by at least one of the stimuli delivered, thus demonstrating the system's plasticity. It is suggested that long-term gates at the synaptic level are responsible for this phenomenon.
journal_name
Brain Resjournal_title
Brain researchauthors
Frostig RD,Gottlieb Y,Vaadia E,Abeles Mdoi
10.1016/0006-8993(83)90567-xsubject
Has Abstractpub_date
1983-08-08 00:00:00pages
211-21issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(83)90567-Xjournal_volume
272pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The serotonin neurotoxin, 5,6-dihydroxytryptamine (5,6-DHT), was injected into the body cavity of snails. Changes induced in the central nervous system (CNS) by the neurotoxin were studied by morphological, electrophysiological and biochemical techniques for up to 90 days following injection. The neurotoxin induced a ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90251-4
更新日期：1992-04-24 00:00:00
abstract：:Using a combination of in situ hybridization and immunohistochemistry, the development of somatostatin (SS)-containing neurons and fibers was examined in the rat dorsal hippocampus and dentate gyrus. The major development of this hippocampal peptidergic system occurs postnatally. At postnatal day 1 (P1), neurons conta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90013-2
更新日期：1988-05-01 00:00:00
abstract：:Spontaneous, synchronous burst discharges originating in the CA2-CA3 region of guinea pig hippocampal slices occur when the concentration of magnesium in the perfusate is reduced below 250 microM. The burst frequency is greater than that seen with other convulsants and afterdischarge is common. Cyclic periods of burst...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(87)80042-2
更新日期：1987-04-28 00:00:00
abstract：:Effect of chronic restraint stress on the number of dendritic spines and excrescences of hippocampal CA3 pyramidal neurons has been investigated. The results revealed a significant increase in the number of dendritic spines of apical and basal dendrites in rats subjected to restraint stress (6 h per day for 21 days). ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00822-8
更新日期：1995-10-02 00:00:00
abstract：:Murine brain cells differentiated for 19 days in culture before treatment for 5 days with 10 microM diazepam. Radioligand binding to the benzodiazepine receptors on membranes obtained from these cultures was determined by the filtration assay method. Decreased binding was observed in the membranes from treated culture...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90117-8
更新日期：1983-12-12 00:00:00
abstract：:Of 602 rats tested for amphetamine-induced or nocturnal rotation (circling behavior), 54.8% (P less than 0.025) had right side biases. Of 292 rats tested in two-lever operant situations, 57.5% (P less than 0.02) preferred the right lever. Right-biased rats were significantly more active and had stronger side preferenc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90737-x
更新日期：1981-01-26 00:00:00
abstract：:Enkephalin immunoreactive neurons within the nucleus tractus solitarius (NTS) were found to project to the parabrachial nucleus of the cat with the use of a combination of immunohistochemistry and retrograde transport of horseradish peroxidase. Double labelled neurons were located in the medial, parvocellular and comm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91521-1
更新日期：1988-03-01 00:00:00
abstract：:This study addressed the issue of multiple parallel auditory processing systems and their relationship to the skull-recorded auditory evoked potentials (AEPs) in the unanesthetized, unrestrained rat. In the preceding paper (Brain Res., 602 (1993) 240-250) it has been shown that auditory cortex activity does not contri...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90690-o
更新日期：1993-02-05 00:00:00
abstract：:Human subjects were asked to perform sinusoidal tracking movements (0.5--3.0 Hz) with their forearms while external torque disturbances were applied at the elbow. The changes in angular position, velocity, and acceleration produced by these disturbances were found to be represented in the reflex changes in EMG activit...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)90946-4
更新日期：1980-07-07 00:00:00
abstract：:Previous research with deafferented subjects suggests that efference copy can be used to update limb position. However, the contributions of efference copy to limb localization are currently unclear. We examined the performance of JDY, a woman with severe, longstanding proprioceptive deficits from a sensory peripheral...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.063
更新日期：2010-10-08 00:00:00
abstract：:Coupling between lumbar motoneurons in the isolated frog spinal cord was studied by using intracellular recordings and intracellular injections of Lucifer Yellow CH. Physiological studies revealed intra- and intersegmental, short latency electrical interactions between many motoneurons. Injections of Lucifer Yellow in...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)90721-7
更新日期：1983-09-12 00:00:00
abstract：:Maternal seizure has adverse effects on brain histology as well as on learning and memory ability in progeny. An enriched environment (EE) is known to promote structural changes in the brain and improve cognitive and motor deficits following a variety of brain injuries. Whether EE treatment in early postnatal periods ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.06.034
更新日期：2012-08-27 00:00:00
abstract：:The aim of this study was to identify the medullary vagal nuclei involved in the different phases of swallowing activated physiologically in a species with an esophagus similar to human. In decerebrate cats, the pharyngeal (0.5-1.0 ml water in pharynx (N=6)) or esophageal (1-3 ml air in esophagus (N=5)) phases of swal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.03.061
更新日期：2004-07-16 00:00:00
abstract：:Hippocampal cholinergic neurons are sensitive to acute ethanol administration, and specific alterations are seen in the functioning of these neurons following chronic ethanol. The present study examined the effects of chronic ethanol exposure and withdrawal on the sensitivity of the hippocampus to local injection of p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90500-1
更新日期：1985-06-03 00:00:00
abstract：:Parkinson's disease (PD) is the second most common neurodegenerative disease worldwide. It is typically associated with motor symptoms originating from the degeneration of nigrostriatal dopamine (DA) neurons. Early stages of PD have been associated with an alteration in DA production in intestinal DAergic neurons alon...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146460
更新日期：2019-12-15 00:00:00
abstract：:Abnormally hyperphosphorylated tau is the major protein component of neurofibrillary tangles, the characteristic lesion of Alzheimer's disease (AD). Protein phosphatases (PP) type 1 (PP-1), type 2A (PP-2A) and type 2B (PP-2B) appear to be involved in the regulation of tau phosphorylation. The incidence of neurofibrill...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)00904-3
更新日期：1996-11-25 00:00:00
abstract：:Retrograde axonal transport method of the fluorescent tracer FluoroGold (FG) was combined with immunocytochemistry to investigate the occurrence of nitric oxide synthase (NOS), somatostatin (SOM), neuropeptide Y (NPY) and vasoactive intestinal peptide (VIP) in both intrinsic and cortically projecting neurons of the ra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02408-8
更新日期：2001-06-29 00:00:00
abstract：:Instructions are an inextricable, yet poorly understood aspect of modern human life. In this paper we propose that instruction implementation and following can be understood as fast Hebbian learning in prefrontal cortex, which trains slower pathways (e.g., cortical-basal ganglia pathways). We present a computational m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.12.025
更新日期：2012-02-23 00:00:00
abstract：:Nerve fibers containing 5-hydroxytryptamine (5-HT) were demonstrated immunohistochemically in the wall of pial vessels associated with the circle of Willis in the guinea pig. The fibers formed a network structure which was more dense in the rostral part of the arterial circle and its branches than in the caudal part. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)91342-x
更新日期：1988-01-12 00:00:00
abstract：:Fluoro-Jade B is known as a high affinity fluorescent marker for the localization of neuronal degeneration during acute neuronal distress. However, one study suggested that fluoro-Jade B stains reactive astroglia in the primate cerebral cortex. In this study, we analyzed the staining of fluoro-Jade B alone or combined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.050
更新日期：2007-01-12 00:00:00
abstract：:Ethanol caused a concentration-dependent loss of PC12 cells over a 24 h interval, accompanied by an increase in intracellular calcium. The specific alpha7 nicotinic receptor partial agonist DMXB attenuated both of these ethanol-induced actions at a concentration (3 microM) found previously to protect against apoptotic...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)01153-6
更新日期：1999-01-16 00:00:00
abstract：:To elucidate the role of the large conductance calcium-activated potassium channel (BK(Ca) channel) in the production of bursting activity, which is characteristic of convulsions, effects of iberiotoxin (IbTX), a selective blocker of the BK(Ca) channel, on bursting activity, induced by various procedures were examined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)01943-0
更新日期：2000-03-31 00:00:00
abstract：:The effect of lead as a neurotoxic agent has been associated with alterations in calcium metabolism. On this line, the present study shows that lead alters the characteristics of [3H]nitrendipine ([ 3H]NDP) binding to rat striatal membranes. In vitro, lead shares the action of calcium in enhancing [3H]NDP binding alth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91202-2
更新日期：1984-11-19 00:00:00
abstract：:In this study, the effects of early vs. delayed tPA treatment on the development of hemorrhagic transformation was compared in a rat thromboembolic model of stroke. Fibrinolysis was performed by administering tPA intravenously at 2 or 6 h after ischemic onset. Twenty-four hours later, confluent hemorrhagic infarction ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)02276-3
更新日期：2000-01-31 00:00:00
abstract：:This study investigated the long-lasting effects of chronic ethanol consumption on the distribution of Schaffer collateral-commissural (SCH/COM) afferents within stratum radiatum of rat hippocampal CA1. Experimental animals were fed an ethanol-containing liquid diet for 20 weeks but were withdrawn from the special die...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90559-5
更新日期：1982-04-08 00:00:00
abstract：:Previous neuroimaging studies provided evidence that visual mental imagery relies, in part, on the primary visual cortex. We hypothesized that, analogous to the finding that motor imagery increases the excitability of motor cortex, visual imagery should increase visual cortex excitability, as indexed by a decrease in ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02478-2
更新日期：2002-05-31 00:00:00
abstract：:The response properties of neurons in the region of striate cortex subserving central retina (0 degrees-2 degrees) and in a region of representation of parafoveal retina (4 degrees-7 degrees) were studied in unanesthetized paralyzed macaque monkeys. Neurons sensitive to the orientation of the stimulus in the visual fi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90240-1
更新日期：1975-12-12 00:00:00
abstract：:The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 2...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90977-4
更新日期：1991-05-03 00:00:00
abstract：BACKGROUND:An important part of the medical treatment of many cerebrovascular diseases is the occlusion of brain supplying arteries. Until now, the risk of this intervention can only be estimated by invasive diagnostics including the risk of cerebrovascular accidents. METHODS AND RESULTS:As a supporting tool, a comput...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.021
更新日期：2006-11-06 00:00:00
abstract：:Cerebellar granule neuronal cultures have been used to study the molecular mechanisms underlying neuronal functions, including neuronal morphogenesis. However, a limitation of this system is the difficulty to analyze isolated neurons because these are required to be maintained at a high density. Therefore, in the pres...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.09.046
更新日期：2013-11-20 00:00:00
