Abstract:
:The diagonal band of Broca (dbB) is involved in central cardiovascular control. In the present study we compared the effects of microinjections of L-glutamate into the dbB of unanesthetized rats with those observed after the injection of L-glutamate into the same area in urethane-anesthetized rats. The microinjection of L-glutamate (10, 30, 100 or 200 nmol/200 nl) into the dbB of urethane-anesthetized rats caused dose-related short-lasting depressor responses The depressor responses to L-glutamate were accompanied by dose-related heart rate reduction. The cardiovascular response to the injection of L-glutamate (10, 30 or 100 nmol/200 nl) into the dbB of unanesthetized rats was characterized as a long-lasting pressor response without consistent heart rate changes. The pressor response was dose-related and presented an ED(50) of approximately 30 nmol/200 nl. The fact that the chemical stimulation of the dbB with L-glutamate caused only dose-related pressor responses in unanesthetized rats suggests that under normal conditions the dbB is predominantly a pressor area. After the characterization of the pressor response to L-glutamate microinjected into the dbB of unanesthetized rats we studied the mechanisms involved in the mediation of these responses. The pressor response to L-glutamate (30 nmol/200 nl) into the dbB was blocked by intravenous pretreatment with the vasopressin antagonist dTyr(CH(2))(5)(Me)AVP (50 microg/kg), suggesting the involvement of circulating vasopressin in this response. Further evidence of the involvement of the endocrine vasopressin system in the pressor response to L-glutamate injected into the dbB was provided by hypophysectomy since L-glutamate (30 nmol/200 nl) microinjection into the dbB of hypophysectomized rats caused only depressor responses. We presently report that chemical stimulation of the dbB with L-glutamate caused only pressor responses in unanesthetized rats that were mediated by vasopressin release into the systemic circulation. Additionally, the results confirmed the existence of an L-glutamate-sensitive depressor system in the dbB, which is predominant in urethane-anesthetized rats or may be evidenced in unanesthetized hypophysectomized rats.
journal_name
Brain Resjournal_title
Brain researchauthors
Tavares RF,de Aguiar Corrêa FMdoi
10.1016/s0006-8993(02)03769-1subject
Has Abstractpub_date
2003-01-10 00:00:00pages
312-9issue
2eissn
0006-8993issn
1872-6240pii
S0006899302037691journal_volume
959pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The expression of HIV-1 negative factor (nef) has been positively correlated with HIV disease progression [Z. Hanna, D.G. Kay, N. Rebai, A. Guimond, S. Jothy, P. Jocicoeur, Nef harbors a makor determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95 (1998) 163-175]. Nef expres...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02213-7
更新日期:2000-05-12 00:00:00
abstract::The effect of arginine vasopressin (AVP) on protein phosphorylation in rat hippocampal synaptic plasma membranes (SPM) was examined. With a crude SPM preparation, AVP (10(-8)-10(-5) M) stimulated phosphorylation of a number of proteins which included a brain-specific protein of 48 kDa called B50 or protein F1, which i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91231-x
更新日期:1986-10-01 00:00:00
abstract::Injections of HRP throughout the upper tectal strata led in 4 cases to the appearance of retrogradely labeled neurons within n.isthmi ventralis, contralateral to the experimental side. An additional case proved that this projection courses through the ventral supraoptic commissure. This is the first description of a c...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90501-5
更新日期:1989-02-27 00:00:00
abstract::The occurrence of hypoxia-ischemia (HI) during early fetal or neonatal stages of an individual leads to the damaging of immature neurons resulting in behavioral and psychological dysfunctions, such as motor or learning disabilities, cerebral palsy, epilepsy or even death. No effective treatment is currently available ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03094-9
更新日期:2002-09-27 00:00:00
abstract::Cerebral amyloid angiopathy (CAA) might disturb the sensitive mechanism of cerebral pressure autoregulation. This study examines whether dynamic cerebral autoregulation (CA) is impaired in the posterior or anterior circulation of CAA patients. Fifteen patients with known CAA on magnetic resonance imaging (MRI) and 14 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.014
更新日期:2019-08-15 00:00:00
abstract::Central nervous system (CNS) disorders are important targets for gene therapy; however, delivery of therapeutic proteins and/or genes to the brain remains a major challenge due to the difficulty of efficiently delivering viral vectors across the blood-brain barrier (BBB). In the present work, we tested the ability of ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.03.014
更新日期:2011-05-10 00:00:00
abstract::Previous research has demonstrated that diabetes induces learning and memory deficits. However, the mechanism of memory impairment induced by diabetes is poorly understood. The present study investigated the effect of streptozotocin (STZ)-induced diabetes on spatial learning and memory using the Morris Water Maze. The...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.07.011
更新日期:2011-09-09 00:00:00
abstract::The activity of neurons identified as or similar to spinothalamic tract cells was compared in anesthetized, intact monkeys and in unanesthetized, decerebrate or spinalized animals. Background activity and responses to A- and C-fiber volleys were smaller in decerebrate than in the other preparations, suggesting the pre...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90454-2
更新日期:1984-07-30 00:00:00
abstract::In this study, seizures in the dentate gyrus were triggered by 2 Hz electrical stimulation while, at the same time, serial changes in paired-pulse depression was measured in free-moving rats. The perforant path was stimulated by paired pulses 25 ms apart and recordings were made in the dentate gyrus. We also observed ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(97)01118-9
更新日期:1997-11-21 00:00:00
abstract::The present study was undertaken to explore the neuronal mechanisms of hypocretin actions on neurons in the nucleus pontis oralis (NPO), a nucleus which plays a key role in the generation of active (REM) sleep. Specifically, we sought to determine whether excitatory postsynaptic potentials (EPSPs) evoked by stimulatio...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02566-6
更新日期:2003-06-27 00:00:00
abstract::Previous immunocytochemical studies have shown immunological differences between neurofilaments in axons and those in dendrites and perikarya of many mature neuron types: it is now known that non-phosphorylated epitopes are normally seen in cell bodies and dendrites of mature neurons, whereas phosphorylated epitopes a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90367-8
更新日期:1988-09-20 00:00:00
abstract::Dantrolene sodium, a skeletal muscle relaxant, was investigated for its action on single motor units of the peroneus tertius muscle in cats anaesthetized with pentobarbitone sodium. Motor axons were isolated in ventral root filaments and their muscle units were identified as either fast-fatiguable (FF), fast-resistant...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90631-5
更新日期:1983-02-21 00:00:00
abstract::Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(03)02990-1
更新日期:2003-08-01 00:00:00
abstract::Error processing during motor control involves the evaluation of "high-level" errors (i.e., failures to meet a system goal) by a frontal system involving anterior cingulate cortex and the evaluation of "low-level" errors (i.e., discrepancies between actual and desired motor commands) by a posterior system involving po...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.04.024
更新日期:2007-06-25 00:00:00
abstract::The involvement of bulbospinal pathways in the antinociceptive effect of clomipramine in experimental pain was studied. The antinociceptive effect of the antidepressant (0.5 mg/kg), intravenously injected, was evaluated after a unilateral lesion of the dorsolateral funiculus. The results showed that this effect was su...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00826-c
更新日期:1995-10-16 00:00:00
abstract::In the present study, we investigated the co-localization pattern of the delta subunit with other subunits of GABA(A) receptors in the rat brain using immunoprecipitation and Western blotting techniques. Furthermore, we investigated whether low concentrations of ethanol affect the delta-subunit-containing GABA(A) rece...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.051
更新日期:2007-08-24 00:00:00
abstract::In anesthetized cats, medial gastrocnemius motor units (MUs) were electrically stimulated via their ventral-root axons with independent random patterns. Muscle tension and homonymous alpha-motoneuron (alpha-MN) membrane potential fluctuations in response to these stimuli were recorded simultaneously. Cross-correlating...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90763-2
更新日期:1985-09-23 00:00:00
abstract::The amygdala is a bilateral temporal lobe brain region which plays an important role in emotional processing. Past studies on the amygdala have shown hemispheric differences in amygdalar processes and responses associated with specific pain and fear behaviors. Despite the functional differences in the amygdala, few st...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.10.028
更新日期:2018-01-01 00:00:00
abstract::We identified cell bodies of a pair of the cardio-inhibitory (CI) neurons in the first thoracic ganglion (TG1) of Bathynomus doederleini. Each of the cell bodies gives rise to a single axon, which runs into the contralateral hemiganglion of TG1 via the commissure and runs to the heart via the fourth root as CI axon. S...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90789-x
更新日期:1991-09-06 00:00:00
abstract::Unanesthetized adult male rats with indwelling right atrial cannulae were used in the majority of experiments. Morphine (MOR, 3.0 mg/kg) caused a large but transient increase in both GH and PRL levels, which could be prevented with naloxone. Disruption of central noradrenergic function with diethyldithiocarbamate (400...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91130-0
更新日期:1980-09-22 00:00:00
abstract::The characteristics of dopamine adenylate cyclase in the rat striatum were first studied on homogenates of fresh tissues. In the assay conditions used, dopamine (10(-4) M) stimulated the enzyme activity by 250%. This effect was completely blocked by fluphenazine (10(-5) M; Ki=9X10(-9) M) and by phentolamine (10(-5) M;...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90228-6
更新日期:1976-05-07 00:00:00
abstract::Dysfunction in the hypothalamic GABAergic system has been implicated in panic syndrome in humans. Furthermore, several studies have implicated the hypothalamus in the elaboration of pain modulation. Panic-prone states are able to be experimentally induced in laboratory animals to study this phenomenon. The aim of the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.09.096
更新日期:2009-12-11 00:00:00
abstract::Protease-activated receptors (PARs), G-protein-coupled receptors, are widely expressed in various tissues, where they participate in physiological and pathological processes, such as hemostasis, proliferation, tissue repair, and inflammation. Recently, we found that PARs were upregulated in the rat retina following op...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2005.04.040
更新日期:2005-06-21 00:00:00
abstract::In a previous study the collateralization of the rubrospinal tract in the spinal cord of rat, cat and monkey was studied by means of the fluorescent retrograde double labeling technique. In the present study the existence of rubrospinal collaterals to the cerebellar interpositus nucleus (NI) has been studied using the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(83)90816-8
更新日期:1983-04-04 00:00:00
abstract::We studied whether, similarly to the auditory modality, short-period temporal integration processes occur in vision. Event-related potentials (ERP) were recorded for occasional stimulus omissions from sequences of patterned visual stimuli. A posterior negative component emerged only when the constant stimulus onset as...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.034
更新日期:2006-08-09 00:00:00
abstract::The development from primary to augmenting responses of somatosensory (SI) cortical area to low-frequency stimulation of the ventrobasal (VB) thalamus or white matter (WM) beneath SI in VB-lesioned preparations was studied by field potential analysis and extracellular unit recording. Compared to the major postsynaptic...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(81)90719-8
更新日期:1981-01-26 00:00:00
abstract::Electrophysiological studies using rats were performed to examine the influence of locus coeruleus (LC) on nucleus accumbens (Acc) neurons. Spike generation by hippocampal stimulation was inhibited by both LC conditioning stimulation and iontophoretic application of noradrenaline, but spikes elicited by stimulation of...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)90172-6
更新日期:1985-07-15 00:00:00
abstract::These experiments were designed to test the hypothesis that the TxA2 mimetic, U46,619, would stimulate group III and IV afferent nerve endings from the hindlimb of the anesthetized cat. Nerve impulses were recorded from the dorsal rootlets of the L7-S1 segments of the spinal cord, and afferent units identified by meas...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01211-5
更新日期:1997-01-02 00:00:00
abstract::Fetal mouse retinal ganglion cell axons have been shown to ramify within co-cultured basement membrane secreting tumor explants and upon isolated basement membranes. Here we report that laminin, a glycoprotein found in basement membranes and adhesion sites of a variety of cell types, acted as a substrate for retinal e...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0165-3806(84)90184-6
更新日期:1984-01-01 00:00:00
abstract::One monoclonal antibody 115A10 (MAb 5A10) specifically stained a subpopulation of retinal bipolar cells in various vertebrates. In the bullfrog retina, MAb 5A10 stained the large bipolar cells, but not the small bipolar cells. Labeling of the living bipolar cells was observed in isolated cell preparation of the frog r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90919-x
更新日期:1987-07-28 00:00:00