Abstract：
:The role of central delta-opioid receptors in the mediation of opioid reinforcement and endogenous reward processes was examined using a non-biased place-preference conditioning procedure. Intracerebroventricular (i.c.v.) administration of the selective delta-receptor agonist, [D-Pen2, D-Pen5]-enkephalin (DPDPE, 10.0-25.0 micrograms) produced a significant preference for the drug-associated place and a similar effect was observed following i.c.v. injections of morphine (10.0 micrograms). Administration of the delta-receptor antagonist, ICI 174,864, at doses (1.0-5.0 micrograms, i.c.v.) which had no aversive effects when tested alone, abolished the reinforcing properties of DPDPE. Such treatment did not, however, modify the effect of morphine. These findings demonstrate the involvement delta- as well as mu-receptors in the motivational properties of opioids and suggest that the activation of either receptor type is sufficient for the elicitation of appetitively reinforcing effects.
journal_name
Brain Resjournal_title
Brain researchauthors
Shippenberg TS,Bals-Kubik R,Herz Adoi
10.1016/0006-8993(87)91667-2subject
Has Abstractpub_date
1987-12-15 00:00:00pages
234-9issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91667-2journal_volume
436pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The effects of glucose injection into the hepatic portal vein on neural activity of the lateral hypothalamic area (LHA) were studied in rats. A majority of identified glucose-sensitive neurons in the LHA were inhibited by portal injection of glucose. This was found to be mediated through the alpha-noradrenergic pathwa...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91332-x
更新日期：1983-04-11 00:00:00
abstract：:Tetramethylpyrazine (TMP) is one of the alkaloids contained in Ligustrazine which has been used in traditional Chinese medicine as an analgesic for injury and dysmenorrhea. ATP can elicit the sensation of pain. This study observed the effects of TMP on ATP-activated current (IATP) in rat DRG neurons. TMP (0.1-1 mM) co...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.076
更新日期：2005-04-08 00:00:00
abstract：:Neuronal cells in primary culture have been demonstrated to possess specific insulin receptors (Boyd et al., J. Biol. Chem., 260 (1985) 15880-15884). Incubation of these cultures with insulin causes a dose-dependent inhibition of maprotiline-sensitive [3H]norepinephrine uptake. Maximum inhibition of 95% of maprotiline...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)91242-4
更新日期：1986-11-19 00:00:00
abstract：:The effects of propylthiouracil (PTU)-induced thyroid deficiency on [14C]acetylcholine synthesis and 14CO2 production from [U-14C]glucose in vitro, by fine prisms of the corpus striatum were investigated in developing rats. Consistent with deficits in choline uptake and choline acetyltransferase activity (Kalaria et a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(85)90114-2
更新日期：1985-06-01 00:00:00
abstract：:The existence of monosynaptic contacts between primary afferents and motoneurons in the lumbar spinal cord of the turtle Pseudemys scripta elegans was demonstrated by intracellular injections of horseradish peroxidase. Three afferent-motoneuron combinations were satisfactorily labeled and revealed 1, 4 and 6 contacts ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90633-x
更新日期：1985-07-22 00:00:00
abstract：:The Fragile X mental retardation syndrome is the largest source of inherited mental retardation. The syndrome usually results from the transcriptional silencing of the fragile X mental retardation gene (FMR1). To date the most prominent reported neuronal abnormalities for the fragile X mental retardation syndrome incl...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02363-1
更新日期：2003-05-02 00:00:00
abstract：:Sprague-Dawley dams were treated with 3 v/v % ethanol in liquid diet from the 8th day gestation through 3 weeks nursing period. Offsprings, ages 1, 2 and 3 weeks, and their dams were studied. Brain weights and their total proteins were not affected by this ethanol treatment. Total enolase activity/mg protein and its i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90963-a
更新日期：1992-05-15 00:00:00
abstract：:Myelination is an important process in brain development, and delays or abnormalities in this process have been associated with a number of conditions including autism, developmental delay, attention deficit disorder, and schizophrenia. Myelination can be sensitive to developmental experience; however, although the ad...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.06.087
更新日期：2009-09-08 00:00:00
abstract：:The effects of 17 beta-estradiol benzoate (EB), ethynodioldiacetate and ovine prolactin on dopamine (DA) turnover have been studied. As an index for a change in turnover, differences in DA depletion following tyrosine hydroxylase inhibition with alpha-methyl-tyrosine methylester were observed. DA was measured by means...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)90728-x
更新日期：1978-06-16 00:00:00
abstract：:We previously reported that aquaporin 4 (AQP4) played a critical role in formation of brain edema and the altered expression of dystroglycan (DG) could relate with AQP4 expression after traumatic brain injury (TBI). However the mechanisms of this process remain unclear. DG was showed could act as a scaffold involved i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146347
更新日期：2019-10-15 00:00:00
abstract：:Excitotoxic effects leading to neuronal cell degeneration are often accompanied by a prolonged increase in the intracellular level of Ca(2+) ions and L-glutamate-induced toxicity is assumed to be mediated via a Ca(2+)-dependent mechanism. Due to their buffering properties, EF-hand Ca(2+)-binding proteins (CaBPs) can a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02753-1
更新日期：2002-08-02 00:00:00
abstract：:This study evaluated the hypothesis that the dorsal motor nucleus (DMN) of the brainstem may mediate the ulcerogenic and acid-stimulatory effects of thyrotropin-releasing hormone (TRH) in rats. To accomplish this, intra-DMN microinjections of TRH (50 and 500 ng) were performed and their effects on acid secretion and g...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(88)90295-8
更新日期：1988-08-30 00:00:00
abstract：:The retinoblastoma protein (pRb) is a key regulator of cell growth, differentiation and survival. pRb(-/-) mice show abnormal neuronal cell death in the developing brain. The function of pRb is regulated by its phosphorylation state. In this study, the phosphorylation of pRb during retinoic acid (RA)-induced neuronal ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01844-2
更新日期：1999-09-25 00:00:00
abstract：:The dependence of the carotid chemosensory response to hypoxia on metabolic substrate and the hypothesis that lactic acidosis is essential for O2 chemoreception were tested. Effects of 3 types of substrate (glucose, glutamate and a mixture of amino acids) on the response to hypoxia (perfusate flow interruption) were m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)91535-m
更新日期：1992-11-20 00:00:00
abstract：:Mitochondrial electron transport chain (ETC) function is selectively reduced in multiple tissues, including brain, from patients with Parkinson's disease (PD) and Alzheimer's disease (AD). The ETC defects are specific to each illness, involve complex I in PD and complex IV in AD, are transferable with mitochondrial DN...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00429-0
更新日期：1997-08-15 00:00:00
abstract：:We recently reported that peripheral nerve injury produced by sciatic nerve transection induces a persistent increase in the expression of the immunoreactive Fos protein product of the c-fos proto-oncogene, an indicator of neuronal activity, in the lumbar spinal cord of the rat and that local anesthetic blockade of th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91089-b
更新日期：1993-07-23 00:00:00
abstract：:Rab3A is a synaptic vesicle-associated GTP-binding protein thought to be involved in modulation of presynaptic transmitter release through regulation of vesicle trafficking and membrane fusion. Electrophysiological studies at central nervous system synapses of Rab3A null-mutant mice have indicated that nerve stimulati...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.03.055
更新日期：2006-05-17 00:00:00
abstract：:Recent evidence has suggested that cholecystokinin (CCK) may act as a physiological opiate antagonist. Both the overlap of CCK and opiate systems within the central nervous system and the fact that exogenous CCK can antagonize opiate analgesia suggest that endogenous CCK systems interact with opiate-mediated pain inhi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91511-2
更新日期：1985-02-18 00:00:00
abstract：:Neonatal rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations of long-term potentiation (LTP) and paired-pulse facilitation (PPF) of hippocampal dentate gyrus in adult rats (90-115 days) following developmental lead exposure were studied in viv...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00739-2
更新日期：1998-09-28 00:00:00
abstract：:Rats were bilaterally olfactory bulbectomized. At 15 days post-lesion, olfactory bulbectomized (OB) rats exhibited significant deficits in the acquisition of passive avoidance learning compared to sham lesioned rats. beta-Adrenoceptor binding in the amygdala, hippocampus and cerebral cortex was assayed with (-)-[125I]...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90783-8
更新日期：1990-10-29 00:00:00
abstract：:The ability of beta-phenylethylamine (PEA) to reverse (1) chlorpromazine-induced activation of striatal tyrosine hydroxylase, and (2) catalepsy produced by chlorpromazine, was examined. PEA, in a dose of 75 mg/kg, caused approximately 50% reduction in the degree of tyrosine hydroxylase stimulation produced by 20 mg/kg...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90979-3
更新日期：1981-05-04 00:00:00
abstract：:Prestin has been identified as a motor protein responsible for outer hair cell (OHC) electromotility. Previous experiments revealed that OHC electromotility and its associated nonlinear capacitance resided in the OHC lateral wall and was not detected at the apical cuticular plate and basal region. In this experiment, ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.04.017
更新日期：2006-06-20 00:00:00
abstract：:The ability of crude cerebrum supernatant to stabilize, at a low temperature, cold-labile microtubules purified from beef brain was studied during development in the rat. The cold-stabilizing activity of the supernatant was low during the first postnatal week, rose significantly during the second postnatal week, and t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90238-6
更新日期：1988-08-01 00:00:00
abstract：:Studies related to brain oscillations pervade the neuroscience literature. Functional correlates of oscillations in the delta, theta, alpha, beta and gamma frequency windows are interpreted in several ways. However, only a small number of reports indicate the need for overall interpretations by integrating all type of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2008.06.102
更新日期：2008-10-15 00:00:00
abstract：:The dmy rat is an autosomal recessive mutant that exhibits severe myelin destruction throughout the white matter of the central nervous system. Recently, a point mutation in intron 3 of the Mrs2 has been found in the dmy rat. Mrs2 encodes an essential component of the major electrophoretic Mg(2+) influx system in mito...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.009
更新日期：2011-05-10 00:00:00
abstract：:The location of stapedius motoneurons in the rat was determined with horseradish peroxidase (HRP) retrograde tracing techniques. After injection of free HRP or wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in the stapedius muscle on one side, labeled neurons were seen ipsilaterally in a region ventromedial to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91532-1
更新日期：1989-01-02 00:00:00
abstract：:A quantitative freeze-fracture study of perivascular astrocytic processes in rat cerebral cortex disclosed rapid disintegration of orthogonal arrays of the intramembrane particles in acute global ischemia. The process apparently preceded the development of astrocytic swelling. ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)91348-9
更新日期：1984-05-21 00:00:00
abstract：:α4βδ GABA(A) receptors (GABARs) have low CNS expression, but their expression is increased by 48h exposure to the neurosteroid THP (3α-OH-5α[β]-pregnan-20-one). THP also increases the efficacy of δ-containing GABARs acutely, where GABA is a partial agonist. Thus, we examined effects of THP (100 nM) and full GABA agoni...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.04.047
更新日期：2012-06-29 00:00:00
abstract：:The control of hypoglossal motoneurons during sleep is important from a basic science perspective as well as to understand the bases for pharyngeal occlusion which results in the obstructive sleep apnea syndrome. In the present work, we used intracellular recording techniques to determine changes in membrane propertie...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02955-3
更新日期：2000-12-08 00:00:00
abstract：:This review provides a snapshot of the current ethical issues related to research with human brain organoids. The issues fall into the following main themes: research oversight; human biomaterials procurement and donor consent; translational delivery; animal research; and organoid consciousness and moral status. Each ...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2020.146653
更新日期：2020-04-01 00:00:00
