Abstract:
:The location of stapedius motoneurons in the rat was determined with horseradish peroxidase (HRP) retrograde tracing techniques. After injection of free HRP or wheat germ agglutinin-horseradish peroxidase (WGA-HRP) in the stapedius muscle on one side, labeled neurons were seen ipsilaterally in a region ventromedial to the rostral half of the facial motor nucleus (VII), extending rostrally to the caudal part of the superior olivary complex (SOC). These labeled neurons, located outside the SOC and facial motor nuclei themselves, constitute the pool of stapedius motoneurons, in agreement with previous descriptions for other species. In order to identify the origin of some inputs to the stapedius motoneurons, injections of herpes virus suis were performed in the stapedius muscle. After replication in the motoneurons, the viruses are transported transneuronally to some premotor neurons, as previously reported in other systems. The presence of the virus was detected by immunofluorescence in neurons corresponding to the stapedius motoneurons labeled with HRP or WGA-HRP. In addition, infected neurons were seen bilaterally at the level of the SOC, in the mediotrapezoid region, where no labeled cells were observed following HRP or WGA-HRP injections in the stapedius muscle. These neurons were considered as infected transneuronally and therefore providing inputs to the pool of stapedius motoneurons. No virus could be detected in cochlear nucleus neurons. These data are consistent with previous observations in the rabbit based on lesion experiments, suggesting that neurons at the level of the SOC are involved in the reflex arc of middle ear muscles.
journal_name
Brain Resjournal_title
Brain researchauthors
Rouiller EM,Capt M,Dolivo M,De Ribaupierre Fdoi
10.1016/0006-8993(89)91532-1subject
Has Abstractpub_date
1989-01-02 00:00:00pages
21-8issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(89)91532-1journal_volume
476pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::While trophic support from targets depends on innervation, recent evidence suggests that local VIP promotes survival of sympathetic neuroblasts prior to target interactions, during the period of neurogenesis. Developmental studies now indicate that VIP expression peaks at embryonic day 15.5 (E15.5) in sympathetic gang...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90461-8
更新日期:1994-11-07 00:00:00
abstract::A feature of neurodegenerative disease is the accumulation of insoluble protein aggregates in the brain. In some conditions, including Amyotrophic Lateral Sclerosis and Frontotemporal lobar degeneration, the primary aggregating entities are RNA binding proteins. Through regulated prion-like assembly, RNA binding prote...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.05.052
更新日期:2014-10-10 00:00:00
abstract::Spontaneous intracerebral hemorrhage (ICH) is one of the most devastating subtypes of stroke. Since angiogenesis is a fundamental process to brain development and repair by new blood vessel formation from pre-existing ones, mediated by numerous angiogenic factors including vascular endothelial growth factor (VEGF), th...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.08.028
更新日期:2007-10-17 00:00:00
abstract::Although the role of STAT3 in cell physiology and tissue development has been largely investigated, its involvement in the development and maintenance of nervous tissue and in the mechanisms of neuroprotection is not yet known. The potentially wide range of STAT3 activities raises the question of tissue- and gender-sp...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.09.074
更新日期:2010-11-29 00:00:00
abstract::Golgi examination of neurons of self-stimulation areas of the lateral hypothalamus and substantia nigra-ventral tegmental areas of adult Wistar rats that had experienced self-stimulation for 10 days revealed a significantly higher number of dendritic branching points in the two self-stimulation areas, and also in the ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91079-v
更新日期:1990-09-10 00:00:00
abstract::Injury of peripheral nerves often results in hyperalgesia (an increased sensitivity to painful stimuli). This hyperalgesia is mediated in part by sympathetic neurotransmitters. We examined the effect of neuropeptide Y (NPY), specific Y1 and Y2 agonists, and an NPY antagonist on peripheral hyperalgesia in rats whose sc...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01265-j
更新日期:1995-01-16 00:00:00
abstract::The role of astrocytes in glutamate toxicity has been controversial. Here, we show that astrocytes in neuron-astrocyte co-cultures increased neuronal sensitivity to chronic glutamate exposure but not to acute exposure. Enhanced neuronal toxicity by chronic exposure was dependent on astrocyte cell numbers. A reduced ge...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2014.10.015
更新日期:2014-11-24 00:00:00
abstract::The firing patterns of up to 4 concurrently active masseter motor units were studied with intramuscular electrodes during a continuous isometric contraction of 15 min duration, in which the subject maintained the mean firing rate of one selected unit at 10 Hz. With this paradigm the net excitation (i.e. mean firing ra...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90467-a
更新日期:1991-05-24 00:00:00
abstract::We observed temporal changes in NACP (precursor protein of non-Abeta component of Alzheimer's disease amyloid), a presynaptic protein a.k. a. alpha-synuclein, in the hippocampus after 5 min ischemia. Intense NACP immunoreactivity was seen transiently around cerebral blood vessels in the CA1 subfield on day 4, and NACP...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00033-x
更新日期:1998-03-30 00:00:00
abstract::The type and cell size of parvalbumin-immunoreactive (PV-Ir) neurones were examined in 14 postmortem brains from elderly control and Alzheimer-type dementia (ATD) patients with the aid of an image analyser. Morphological features of PV-Ir neurones suggested the existence of PV in the non-pyramidal interneurones in the...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90974-7
更新日期:1987-08-18 00:00:00
abstract::Cerebral cells of origin for the corticospinal (CST), corticopontine (CP), corticorubral (CR) and corticostriatal (CS) fibers in the rat were identified following the simultaneous retrograde transport of propidium iodide (PI), fast blue (FB), fluorogold (FG) and diamidino yellow (DY). PI was injected into the contrala...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91629-s
更新日期:1992-07-24 00:00:00
abstract::We electrically stimulated individual Mauthner (M-) cells to determine their motor contribution to C-starts of swimming goldfish. In comparison with sensory-evoked C-starts, M-reflexes triggered by electrical stimulation of single M-cells were significantly weaker and less variable. Stage 1 turns were both longer in d...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)91012-6
更新日期:1990-05-28 00:00:00
abstract::The choroid plexus epithelium constitutes the structural basis of the blood-cerebrospinal fluid barrier. We previously demonstrated that Streptococcus suis (S. suis), a relevant cause of bacterial meningitis in pigs and humans, affects porcine choroid plexus epithelial cell (PCPEC) barrier function and integrity. We n...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.05.041
更新日期:2006-07-19 00:00:00
abstract::The rapid saltatory motion of intra-axonal particles detected by dark-field microscopy in myelinated axons isolated from sciatic nerves of adult Xenopus laevis was inhibited by colchicine or vinblastine at a concentration of larger than or equal to 0.1 mM. Both the predominant somatopetal transport and the somatofugal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(77)90990-8
更新日期:1977-06-10 00:00:00
abstract::Rats anticipate a scheduled daily meal by entrainment of a circadian pacemaker separate from the light-entrainable circadian pacemaker located in the suprachiasmatic nuclei (SCN). The site and molecular mechanisms of the food-entrainable pacemaker are unknown. The intrinsic period (tau) of the SCN pacemaker is signifi...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)03042-6
更新日期:2001-11-23 00:00:00
abstract::We report an fMRI experiment on deductive reasoning with acoustically presented problems. Twelve volunteers received problems in which an acoustic stimulus came from the left or the right of another stimulus. The participants then heard a third stimulus coming from the left or the right of one of the proceeding stimul...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2008.10.025
更新日期:2009-01-16 00:00:00
abstract::Wild red foxes, proverbially cunning carnivores, are investigated for adult hippocampal neurogenesis and morphological characteristics of the dentate gyrus. Adult red foxes harbor almost 15-times more young, doublecortin-positive neurons in their dentate gyrus than domesticated dogs. The number of doublecortin-positiv...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.02.075
更新日期:2010-04-30 00:00:00
abstract::Electrical and pharmacological properties of currents induced by compounds having affinities for putative sigma receptors were investigated with NCB20 cells by use of the whole-cell patch-clamp technique. Antipsychotics and naloxone induced inward currents with a decrease in membrane conductance at a holding potential...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91232-7
更新日期:1994-02-21 00:00:00
abstract::Cerebellar Purkinje neurons (PNs) are selectively vulnerable to AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepriopionic acid)-induced delayed neurotoxicity known as dark cell degeneration (DCD) that is expressed as cytoplasmic and nuclear condensation, neuron shrinkage, and failure of physiology. The present study ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2003.09.048
更新日期:2003-12-24 00:00:00
abstract::Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrilla...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90914-0
更新日期:1987-07-28 00:00:00
abstract::Accumulating evidence indicates that neurite degeneration occurs via a distinct mechanism from somal death programs. We have previously shown that neuritic ATP level in sympathetic neurons decreases, whereas somal ATP level remains unaltered during degeneration caused by the microtubule-disrupting agent, vinblastine. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2004.09.050
更新日期:2004-12-24 00:00:00
abstract::Neurodegenerative disorders have attracted attention in last decades due to their high incidence in the world. The p53/miR-34a axis triggers apoptosis and suppresses viability in multiple types of cells, but little is known about its role in neurodegenerative diseases. In this study, we showed that presenilin (PS)-2, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2017.01.034
更新日期:2017-05-01 00:00:00
abstract::The neurotrophic effect of bFGF on dopamine (DA) neurons in vitro depends upon its mitogenic activity on glial cells. We examined whether glial secretion of the dopaminergic growth factor GDNF is responsible for the trophic activity of bFGF on mesencephalic DA neurons. When added with lower concentrations of bFGF, GDN...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(96)00311-3
更新日期:1996-06-10 00:00:00
abstract::The monoclonal antibody E/C8 was originally generated against chicken dorsal root ganglia. The antigen detected by E/C8, NAPA-73, is an intermediate filament-associated protein. NAPA-73 was shown to be one of the earliest neuronal markers to appear during development since it appears in some neuronal precursor cells o...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91289-3
更新日期:1987-09-22 00:00:00
abstract::(1) The possibility that water intake elicited by the administration of angiotensin-II to the preoptic region (POA), subfornical organ and anterior third ventricle is mediated by separate neural systems was investigated in 58 male Wistar rats using electrolytic lesion techniques. (2) Lesions of the midlateral hypothal...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(76)90189-x
更新日期:1976-05-28 00:00:00
abstract::Sites which bind oxytocin and vasopressin with high affinity were detected in the brain and upper spinal cord of 12 human subjects, using in vitro light microscopic autoradiography. Tissue sections were incubated with tritiated vasopressin, tritiated oxytocin or an iodinated oxytocin antagonist. The ligand specificity...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90345-v
更新日期:1991-08-02 00:00:00
abstract::It has been hypothesized that a disruption of gamma-aminobutyric acid (GABA) receptor-mediated processes may be involved in the pathophysiology of focal epilepsy. This disinhibition hypothesis has been postulated from the results of in vitro experiments of the interictal activity of focal epilepsy. Less is known, howe...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02209-5
更新日期:2000-05-26 00:00:00
abstract::Recent physiological evidence indicates that vagal postganglionic control of left ventricular contractility is mediated by neurons found in a ventricular epicardial fat pad ganglion. In the dog this region has been referred to as the cranial medial ventricular (CMV) ganglion [J.L. Ardell, Structure and function of mam...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00613-1
更新日期:1998-08-17 00:00:00
abstract::Vasopressinergic structures were examined within the magnocellular nuclei of the human basal forebrain. Vasopressinergic neurons were found in all parts of the diagonal band nucleus, and less frequently in the anteromedial subnucleus of the basal nucleus (Meynert). They belong to the group of large multipolar neurons,...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90678-5
更新日期:1990-10-15 00:00:00
abstract::The effects of indomethacin (10 mg/kg) on the release of the transmitter amino acids, glutamate, aspartate, GABA, and of the purines, adenosine and inosine, from the cerebral cortex was studied in a four-vessel occlusion rat model of cerebral ischemia/reperfusion. In comparison with the control group, indomethacin sig...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)90248-8
更新日期:1994-08-01 00:00:00