Abstract：
:Various cytoskeletal proteins have been implicated in the formation of neurofibrillary tangles in Alzheimer's disease. A monoclonal antibody to non-phosphorylated neurofilament protein labels a distinct subset of pyramidal cells in the normal human cortex which have a distribution very similar to that of neurofibrillary tangles in brains from patients with Alzheimer's disease. In addition, regions and layers that normally contain a high density of such cells, in Alzheimer's disease, have large numbers of neurofibrillary tangles and few remaining immunoreactive cells.
journal_name
Brain Resjournal_title
Brain researchauthors
Morrison JH,Lewis DA,Campbell MJ,Huntley GW,Benson DL,Bouras Cdoi
10.1016/0006-8993(87)90914-0subject
Has Abstractpub_date
1987-07-28 00:00:00pages
331-6issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(87)90914-0journal_volume
416pub_type
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