Abstract：
:The monoclonal antibody E/C8 was originally generated against chicken dorsal root ganglia. The antigen detected by E/C8, NAPA-73, is an intermediate filament-associated protein. NAPA-73 was shown to be one of the earliest neuronal markers to appear during development since it appears in some neuronal precursor cells of the peripheral nervous system during development. Using [3H]thymidine pulse-chase experiments combined with immunocytochemistry, it is shown that the dividing neuroblasts from 6-day-old embryonic chick brains do not express NAPA-73. Only neurons that have undergone their terminal cell division either in the embryo or in cell culture express the E/C8 immunoreactivity. We conclude that E/C8 is a marker for postmitotic neurons in chick brain. The contrast between our findings and previous reports identifying NAPA-73 as one of the earliest neuronal markers may reflect a difference between the central and peripheral nervous systems.
journal_name
Brain Resjournal_title
Brain researchauthors
Wu DK,de Vellis Jdoi
10.1016/0006-8993(87)91289-3subject
Has Abstractpub_date
1987-09-22 00:00:00pages
186-93issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(87)91289-3journal_volume
421pub_type
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