Abstract：
:The two major metabolites of (+/-)3,4-methylenedioxyamphetamine (MDA), alpha-methyldopamine (alpha-MeDA) and 3-O-methyl-alpha-methyldopamine (3-O-Me-alpha-MeDA), were administered to rats intracerebroventricularly and into brain parenchyma. In addition, their precursors, (alpha-MeDOPA and 3-O-Me-alpha-MeDOPA, respectively) were administered systemically, individually and in combination. None of these treatments produced a lasting depletion of brain serotonin (5-HT). These findings suggest that neither of MDA's major metabolites mediate its toxic effects on 5-HT neurons and that either a minor metabolite is responsible or that alternate mechanisms are involved.
journal_name
Brain Resjournal_title
Brain researchauthors
McCann UD,Ricaurte GAdoi
10.1016/0006-8993(91)91297-esubject
Has Abstractpub_date
1991-04-05 00:00:00pages
279-82issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(91)91297-Ejournal_volume
545pub_type
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