Abstract：
:Spontaneous, synchronous burst discharges originating in the CA2-CA3 region of guinea pig hippocampal slices occur when the concentration of magnesium in the perfusate is reduced below 250 microM. The burst frequency is greater than that seen with other convulsants and afterdischarge is common. Cyclic periods of bursting resembling ictal discharges occur spontaneously in some slices and with repetitive stimulation (0.5-2 Hz) in most slices. The spontaneous bursts are blocked by 2-APV suggesting the involvement of NMDA receptors in their generation.
journal_name
Brain Resjournal_title
Brain researchauthors
Schneiderman JH,MacDonald JFdoi
10.1016/s0006-8993(87)80042-2subject
Has Abstractpub_date
1987-04-28 00:00:00pages
174-8issue
1eissn
0006-8993issn
1872-6240pii
S0006-8993(87)80042-2journal_volume
410pub_type
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