Sodium valproate decreases synaptic potentiation and epileptiform activity in hippocampus.

abstract：:Alterations in brain high energy phosphate compounds, using 31P-NMR (nuclear magnetic resonance) spectroscopy, were measured in vivo in young adult (3-4 months) rats following prenatal exposure to ligands acting specifically at benzodiazepine (BDZ) binding sites. The exposure induced a decrease in intracellular pH tha...

journal_title：Brain research

authors： Miranda R,Ceckler T,Guillet R,Kellogg C

更新日期：1990-01-01 00:00:00

abstract：:Chronic hydrocephalus is one of the severe complications after subarachnoid hemorrhage (SAH). However, there is no efficient treatment for the prevention of chronic hydrocephalus, partially due to poor understanding of underlying pathogenesis, subarachnoid fibrosis. Transforming growth factor-β1(TGF-β1) is a potent fi...

journal_title：Brain research

authors： Yan H,Chen Y,Li L,Jiang J,Wu G,Zuo Y,Zhang JH,Feng H,Yan X,Liu F

更新日期：2016-01-01 00:00:00

abstract：:Our previous studies have indicated that oxygen radicals, produced during reoxygenation following short-term arterial hypoxia, lead to sustained suppression of cerebral arteriolar responses to N-methyl-D-aspartate (NMDA). However, whether arteriolar dilator responses to NMDA are reduced during arterial hypoxia has nev...

journal_title：Brain research

authors： Bari F,Thore CR,Louis TM,Busija DW

更新日期：1998-01-12 00:00:00

abstract：:We have studied the modulation of hippocampal neuron morphological development in vitro using surfaces derivatized with aminosilane self-assembled monolayers (SAMs). The efficacies of model SAMs, alone, or in combination with adsorbed heparan sulfate glycosaminoglycan (HS), are related to the physical and chemical pro...

journal_title：Brain research

authors： Stenger DA,Pike CJ,Hickman JJ,Cotman CW

更新日期：1993-12-10 00:00:00

abstract：:Even though animal and human studies show alterations in dopamine transporter (DAT) sites after alcohol withdrawal, the role of DAT in influencing either alcoholic or depressive behavior has not been examined extensively. Given that the Wistar-Kyoto (WKY) rat is a putative animal model of depressive behavior, the pres...

journal_title：Brain research

authors： Jiao X,Paré WP,Tejani-Butt SM

更新日期：2006-02-16 00:00:00

abstract：:The outer plexiform layer (OPL) of the retina has been studied in the developing cat, from E (embryonic day) 30. Prior to E51 the layer could not be detected, the retina comprising two cell layers, an inner layer which becomes the ganglion cell layer of the adult, and an outer 'neuroblast' layer. The OPL was first det...

journal_title：Brain research

authors： Rapaport DH,Stone J

更新日期：1982-11-01 00:00:00

abstract：:Antisense oligodeoxynucleotide (AS ODN) probes directed against the alpha-subunit of different G-proteins have been used to differentiate feeding responses in rats elicited by different opioid agonists, including morphine, beta-endorphin and dynorphin. Furthermore, antisense probes directed against G(o)alpha, but not ...

journal_title：Brain research

authors： Hadjimarkou MM,Silva RM,Rossi GC,Pasternak GW,Bodnar RJ

更新日期：2002-11-15 00:00:00

abstract：:During normal aging, men experience a significant decline in testosterone levels and a compensatory elevation in levels of gonadotropin luteinizing hormone (LH). Both low testosterone and elevated LH have been identified as significant risk factors for the development of Alzheimer's disease (AD) in men. It is unclear ...

journal_title：Brain research

authors： Rosario ER,Carroll JC,Pike CJ

更新日期：2012-07-23 00:00:00

abstract：:Previous research has demonstrated that in the Siberian hamster, both photoperiod and estrous cyclicity alter the profile of noradrenergic activity with the paraventricular nucleus of the hypothalamus (PVN), and that noradrenergic activity is correlated with changes in circulating levels of prolactin. Work from our la...

journal_title：Brain research

authors： Dodge JC,Badura LL

更新日期：2004-08-06 00:00:00

abstract：:In vivo microdialysis combined with high performance liquid chromatography (HPLC) with electrochemical detection, was used to study the effect of MK-801 (0.1 mg/kg i.p.) on extracellular concentrations of dopamine (DA) 3,4-dihydroxyphenylacetic acid (DOPAC), serotonin (5-HT), norepinephrine (NE) and DOPAC/DA ratio in ...

journal_title：Brain research

authors： Hatip-Al-Khatib I,Mishima K,Iwasaki K,Fujiwara M

更新日期：2001-05-25 00:00:00

abstract：:Ionic currents induced by glutamate, kainate, quisqualate, and N-methyl-D-aspartate (NMDA) in cultured septal neurons were analyzed by fluctuations analysis. The power spectrum (PWS) of NMDA current fluctuations always fitted a single Lorentzian. PWSs of the other agonists fitted the sum of two Lorentzians; however, t...

journal_title：Brain research

authors： Shingai R,Ebina Y

更新日期：1988-05-10 00:00:00

abstract：:In this report, using a push-pull perfusion technique, we examined in vivo the effects of exogenous dopamine (DA) on the output of neurochemical substances from the caudate nucleus (CN) of freely behaving rats. Exogenous DA, at concentrations of 10(-5) M, 5 x 10(-5) M and 10(-4) M, in modified Krebs-Ringer phosphate m...

journal_title：Brain research

authors： Chang GD,Ramirez VD

更新日期：1989-03-06 00:00:00

abstract：:Effects of methamphetamine (MAP) on the extracellular neuropeptide Y (NPY) and noradrenaline (NA) levels were examined in the vicinity of the paraventricular nucleus (PVN) of freely moving rats by means of push-pull perfusion. The NA and NPY levels increased significantly in 30-60 min and reached the maximum level in ...

journal_title：Brain research

authors： Yoshihara T,Honma S,Mitome M,Honma K

更新日期：1996-01-22 00:00:00

abstract：:We report the characterization of a new class of glutamate uptake inhibitors isolated from Phoneutria nigriventer venom. Glutamate transport activity was assayed in rat cerebrocortical synaptosomes by using [(3)H]-L-glutamate. PhTx4 inhibited glutamate uptake in a dose dependent manner. The IC(50) value obtained was 2...

journal_title：Brain research

authors： Mafra RA,Figueiredo SG,Diniz CR,Cordeiro MN,Cruz JD,De Lima ME

更新日期：1999-06-12 00:00:00

abstract：:It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippoc...

journal_title：Brain research

authors： de Lanerolle NC,Kim JH,Robbins RJ,Spencer DD

更新日期：1989-08-28 00:00:00

abstract：:The substance P and Met-enkephalin content were measured in the rat lumbar spinal cord after monolateral section of the sciatic nerve. The proximal stump of the lesioned nerve was either ligated, limiting the formation of neuroma, or sutured intraperitoneally, allowing the formation of a very large neuroma. Both types...

journal_title：Brain research

authors： Di Giulio AM,Mantegazza P,Dona M,Gorio A

更新日期：1985-09-09 00:00:00

abstract：:This study in lightly anesthetized rats found that unilateral electrical stimulation delivered to the ventral part of the thalamic nucleus submedius (Sm), the thalamic reuniens nucleus (Re) and the hypothalamic dorsal area (DA) markedly depressed the TF reflex, and this inhibitory effect increased following increasing...

journal_title：Brain research

authors： Zhang YQ,Tang JS,Yuan B,Jia H

更新日期：1995-10-23 00:00:00

abstract：:Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...

journal_title：Brain research

authors： Kessler M,Mutneja MS,Rogers G,Lynch G

更新日期：1998-02-02 00:00:00

abstract：:Seven days after adrenalectomy (ADX) the number of vasoactive intestinal peptide (VIP)- and corticotropin-releasing factor (CRF)-immunoreactive cells in the parvocellular part of the rat paraventricular nucleus (PVN) increased markedly. Dexamethasone in the drinking water (started immediately after ADX) or its local i...

journal_title：Brain research

authors： Bartha L,Kiem DT,Makara GB

更新日期：1990-01-08 00:00:00

abstract：:A significant fall in the number of GABA-immunoreactive cells in laminae I-III of the rat spinal cord occurred in the somatotopic area of projection of the sciatic nerve after nerve transection. The decrease started at 2 weeks post-neurectomy, and at 4 weeks ipsilateral mean cell numbers were approximately 72% of cont...

journal_title：Brain research

authors： Castro-Lopes JM,Tavares I,Coimbra A

更新日期：1993-08-27 00:00:00

abstract：:Neurotrophins are potent regulators of the survival of different neuronal populations in the CNS. Little is known of the immunodistribution of neurotrophin-3 (NT-3) and tyrosine kinase C (TrkC) receptor in the frog visual system, which can successfully regenerate and recover vision after injury. In this study we show ...

journal_title：Brain research

authors： Duprey-Díaz MV,Blagburn JM,Blanco RE

更新日期：2003-08-22 00:00:00

abstract：:The hypothesis that early social isolation results in long-term alterations in dopamine receptor sensitivity was tested using older adult rhesus monkeys. Isolated and control monkeys were challenged with apomorphine (0.1 and 0.3 mg/kg), and the drug effects on spontaneous blink rate, stereotyped behavior, and self-inj...

journal_title：Brain research

authors： Lewis MH,Gluck JP,Beauchamp AJ,Keresztury MF,Mailman RB

更新日期：1990-04-09 00:00:00

abstract：:The human neostriatum was found to contain large neurons (maximum diameter: 30-40 microns) that stain intensely for acetylcholinesterase (AChE). These neurons are few in number, representing less than 5% of the total striatal neuronal population, and appear uniformly scattered throughout the caudate nucleus and putame...

journal_title：Brain research

authors： Parent A,Csonka C,Etienne P

更新日期：1984-01-16 00:00:00

abstract：:We have examined the question of whether alpha-tubulin is detyrosylated during axonal transport in retinal ganglion cell axons and axons of spinal motor neurons. The degree of tyrosylation of alpha-tubulin was estimated from immunocytochemistry and immunoblotting with two anti-alpha-tubulin monoclonals, one of which (...

journal_title：Brain research

authors： Burgoyne RD,Norman KM

更新日期：1986-08-27 00:00:00

abstract：:We investigated the effects of collagen II-induced arthritis on two cerebrospinal fluid (CSF) enzymes converting dynorphin A and substance P (SP), namely dynorphin-converting enzyme (DCE) and substance P endopeptidase (SPE). The products generated by these enzymes are the bioactive fragments Leu-enkephalin-Arg6 and su...

journal_title：Brain research

authors： Persson S,Post C,Holmdahl R,Nyberg F

更新日期：1992-05-29 00:00:00

abstract：:Recently, a novel method for detection of DNA synthesis has been developed based on the incorporation of 5-ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction). In the present stud...

journal_title：Brain research

authors： Zeng C,Pan F,Jones LA,Lim MM,Griffin EA,Sheline YI,Mintun MA,Holtzman DM,Mach RH

更新日期：2010-03-10 00:00:00

abstract：:Phrenic afferents are capable of attenuating the phrenic motor response elicited by the intercostal-to-phrenic excitatory reflex in decerebrate, paralyzed cats. High spinal transection eliminates the attenuating effect of the bilateral phrenic-to-phrenic inhibitory reflex. These results indicate that although phrenic ...

journal_title：Brain research

authors： Speck DF

更新日期：1987-06-23 00:00:00

abstract：:The axonal transport of radiolabeled slow phase proteins and fast phase glycoproteins was studied in rabbit hypoglossal nerve one week after axotomy. The nerves were ligated and cut to prevent axonal regeneration into the distal stump. In this situation of obstructed axonal outgrowth, the axonal transport of these com...

journal_title：Brain research

authors： Frizell M

更新日期：1982-10-28 00:00:00

abstract：:The visual properties of cells in the cat ventral lateral geniculate nucleus (LGV) identified antidromically from the pretectum and/or superior colliculus (projection cells) were studied in comparison with those of LGV neurons which could not be activated antidromically (non-projection cells). ON-phasic receptive fiel...

journal_title：Brain research

authors： Hada J,Yamagata Y,Hayashi Y

更新日期：1986-01-15 00:00:00

abstract：:Since hypertension and/or hyperglycemia are risk factors for stroke, we examined whether the putative neuroprotectant, nicotinamide (NAm), could protect spontaneously hypertensive rats (SHR) or diabetic Fischer 344 rats against focal cerebral ischemia using a model of permanent middle cerebral artery occlusion (MCAo)....

journal_title：Brain research

authors： Sakakibara Y,Mitha AP,Ayoub IA,Ogilvy CS,Maynard KI

更新日期：2002-03-22 00:00:00