The effect of elevated potassium on the adult mollusc giant neurone survival and neurite formation in culture.

Abstract:

:The number of viable neurones calculated as soon as adult mollusc ganglia tissue was digested and over different periods of cultivation, show that elevated K+ prevents degradation of intercellular contacts, preserves neurones against lysis, prolongs the time course of neurone survival in culture and inhibits neurite formation. K+ depolarizing effect is maintained throughout the whole course of cultivation; when elevated K+ is substituted by normal K+ the resting potential of neurones recovers. The effect of elevated K+ on neurone survival and the capability for neurite formation is not due to membrane depolarization, but seems to be related to an influence on intracellular ionic homeostasis.

journal_name

Brain Res

journal_title

Brain research

authors

Kostenko MA,Tretjak NN,Musienko VS

doi

10.1016/0006-8993(82)90044-0

subject

Has Abstract

pub_date

1982-03-18 00:00:00

pages

183-92

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(82)90044-0

journal_volume

236

pub_type

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