Abstract：
:The effect of neuroprotective drugs on the early and late electrophysiological manifestations of photothrombotic occlusion of distal branches of middle cerebral artery was studied in rats treated with MK-801 and Cerebrolysin (CL). DC potentials were recorded from the irradiated cortex (ischemic core), from the adjacent penumbra zone and from remote intact cortex. Irradiation elicited after a few minutes of spontaneous spreading depression (SD) waves followed during 10-15 min by focal ischemic depolarization (FID) developing in the irradiated cortex and spreading into the perifocal areas. While the core FID amplitude reached about 30 mV and decayed during subsequent 2 h to 10-13 mV, FID in the penumbra zone was broken by periods of partial repolarization and returned during 30-90 min almost to baseline. At the same time, generation of spontaneous SD waves almost stopped. MK-801 (0.5 mg/kg, i.p., 45 min after ischemia) blocked SD waves, but did not shorten penumbra FID, the decay of which was slowed down to the rate found in the ischemic core. CL treatment (2.5 ml/kg, i.p. , 1 h after ischemia) did not influence FID in the acute phase of the experiment, but its 10-day administration facilitated post-ischemic recovery indicated by higher amplitude of evoked SD waves penetrating into the former penumbra zone. Morphological examination showed that the volume of total and partial necrosis was increased in the MK-801 group and marginally reduced in the CL group. It is suggested that the absence of the SD-induced hyperperfusion episodes in MK-801-treated rats may accelerate perifocal thrombotization in this model of focal ischemia.
journal_name
Brain Resjournal_title
Brain researchauthors
Koroleva VI,Korolev OS,Loseva E,Bures Jdoi
10.1016/s0006-8993(97)01448-0subject
Has Abstractpub_date
1998-03-09 00:00:00pages
104-14issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)01448-0journal_volume
786pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Methionine (Met) enkephalin is detectable in rat hypothalamic and neurointermediate lobe (NIL) tissue extracts using a specific radioimmunoassay. Reversed-phase HPLC revealed that only the pentapeptide form was present in the extracts. Total amounts of Met-enkephalin in extracts containing the median eminence (ME), su...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90895-i
更新日期：1990-05-14 00:00:00
abstract：:The present study attempts to elucidate the possible role of adenosine 3',5'-monophosphate (cAMP) and prostaglandin E2 (PGE2) in the function of the neural luteinizing hormone-releasing hormone (LH-RH) apparatus. To this end, in vitro LH-RH release from superfused hypothalamic fragments and cAMP production by hypothal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90162-9
更新日期：1986-10-29 00:00:00
abstract：:The urethrogenital (UG) reflex is a spinal sexual reflex which is tonically inhibited in the intact male rat by neurons in the nucleus paragigantocellularis (nPGi). The medial preoptic area of the hypothalamus (MPOA) is involved in the activation of male sexual behavior. The present study examines the effect of hypoth...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90638-6
更新日期：1994-02-28 00:00:00
abstract：:Alzheimer's disease (AD) classically presents with gray matter atrophy, as well as feature significant white matter abnormalities. Previous evidence indicates the overall burden of these pathological changes continues to advance as the disease progresses. The aim of this study was to investigate whether pathological a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.03.052
更新日期：2013-06-17 00:00:00
abstract：:Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90991-4
更新日期：1991-02-22 00:00:00
abstract：:The size differences in the midsagittal cerebellum, its individual lobules and its layers are studied in homozygous diabetic (HOM) and heterozygous Brattleboro rats on postnatal days 12, 24 and 180. As has been reported for total cerebellar weight, no significant reduction in cerebellar size in HOM rats occurs at day ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90296-8
更新日期：1986-05-01 00:00:00
abstract：:The cellular and intracellular localization of the epsilon-subspecies of protein kinase C (PKC) in the rat brain was demonstrated by immunocytochemistry using specific antibodies against epsilon-PKC. The epsilon-PKC-specific immunoreactivity was most abundant in the hippocampal formation, olfactory tubercle and Callej...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91512-q
更新日期：1993-04-02 00:00:00
abstract：:Available evidence suggests that regular, moderate-intensity exercise has beneficial effects on neural health, perhaps including neuroprotection. To evaluate this idea further, we compared the severity of kainate-induced neuronal loss in exercised versus sedentary female rats. Stereological estimations of neuron numbe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(03)02365-5
更新日期：2003-05-09 00:00:00
abstract：:Inhibitory GABAergic synaptic transmission in the mammalian hippocampus depends upon a hyperpolarized reversal potential for Cl(-) (ECl). To examine the regulation of ECl hyperpolarization we cultured hippocampal neurons for two weeks in either a low- or a high-concentration of KCl (2.6 or 18.7 mM, respectively). Neur...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.02.038
更新日期：2008-04-18 00:00:00
abstract：:The central myelin sheaths of the recessive autosomal mutant mouse, Shiverer, were investigated by electron microscopy with special reference to the pattern of myelin formation. The results obtained may be summarized as follows: (1) the major dense line of myelin lamellae generally failed to be formed, but the axons w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90269-9
更新日期：1981-08-24 00:00:00
abstract：:The blood-brain barrier (BBB) permeability primarily increases in cerebral venules during acute hypertension. Methyl-β-cyclodextrin (MβCD), a cholesterol-depleting agent, decreases the expression of caveolins disrupting caveolar structures. We aimed to determine the effects of MβCD on the BBB permeability of angiotens...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.03.024
更新日期：2019-07-15 00:00:00
abstract：:Body temperature changes and heat shock protein (HSP-72) induction in the caudate nucleus were studied in female C57BL/6N mice pretreated with ibogaine (50 mg/kg) and sacrificed 48 h. after a single dose of methamphetamine (20 mg/kg). Methamphetamine injection resulted in hyperthermia and induced HSP-72 expression, wh...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01154-3
更新日期：1999-03-27 00:00:00
abstract：:Immunocytochemistry and high-performance liquid chromatography with electrochemical detection (HPLC-ED) were used, more than 76 days after infraorbital nerve (ION) transection, to examine the distribution and density of serotonin-immunoreactive (5-HTIR) axons, as well as serotonin (5-HT) and 5-hydroxyindoleacetic acid...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90040-i
更新日期：1990-12-17 00:00:00
abstract：:We used whole-head magnetoencephalograpy (MEG) to record changes in neuromagnetic N100m responses generated in the left and right auditory cortex as a function of the match between visual and auditory speech signals. Stimuli were auditory-only (AO) and auditory-visual (AV) presentations of /pi/, /ti/ and /vi/. Three t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.04.077
更新日期：2008-11-25 00:00:00
abstract：:Neural correlates of conscious awareness can be comfortably studied when awareness of the target stimuli is a varying dependent variable in the experimental conditions where the key independent variables are kept invariant. We presented vernier targets backward masked by an invariant grating with invariant SOA. EEG da...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.12.085
更新日期：2009-05-19 00:00:00
abstract：:The purpose of the present study was to determine the effects of chronic (2-month) estradiol (E2) treatment on cholinergic function in the frontal cortex, hippocampus and hypothalamus of the female rat. Chronic E2 treatment selectively increased choline acetyltransferase (ChAT) activity in the frontal cortex and decre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)90871-8
更新日期：1990-08-20 00:00:00
abstract：:The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map ascending pathways which are influenced by arousing electrical stimulation of the midbrain reticular formation (RET) in alert rats. The major finding was that RET stimulation produces selective patterns of metabolic activation and suppression in di...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91190-4
更新日期：1985-09-30 00:00:00
abstract：:When observing bistable stimuli, the percept can change in the absence of changes in the stimulus itself. When intermittently presenting a bistable stimulus, the number of perceptual alternations can increase or decrease, depending on the duration of the period that the stimulus is removed from screen between stimulus...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.11.078
更新日期：2009-02-03 00:00:00
abstract：:The nucleus of the solitary tract (NTS) is a critical structure involved in coordinating autonomic and visceral activities. Previous independent studies have demonstrated efferent projections from the NTS to the nucleus paragigantocellularis (PGi) and the central nucleus of the amygdala (CNA) in rat brain. To further ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.08.051
更新日期：2006-10-30 00:00:00
abstract：:Small injections of two highly sensitive anterograde tracers, Phaseolus vulgaris-leucoagglutinin (PHA-L) and biocytin, into the striatum and the subthalamic nucleus of squirrel monkeys (Saimiri sciureus) have revealed a high degree of convergence of striatal and subthalamic fibers upon single pallidal cells. Both affe...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90648-s
更新日期：1992-01-13 00:00:00
abstract：:As a means of probing the chemotransducer, impulse sequences from in vitro, superfused sinus nerve-carotid body preparations were analyzed for departures from randomness. Twelve of 17 spike trains showed interval histograms that did not differ significantly from exponential. Thus these sequences resembled a Poisson (r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90908-9
更新日期：1984-01-30 00:00:00
abstract：:Central nervous system (CNS) disorders are important targets for gene therapy; however, delivery of therapeutic proteins and/or genes to the brain remains a major challenge due to the difficulty of efficiently delivering viral vectors across the blood-brain barrier (BBB). In the present work, we tested the ability of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2011.03.014
更新日期：2011-05-10 00:00:00
abstract：:The hippocampal formation of the rat contains two types of membrane-bound cholinergic binding sites, as revealed by specific binding of [3H]quinuclidinyl benzilate (QNB) or of a-[125I]bungarotoxin (a-Btx). The sites differ in pharmacological profile, sensitivity to detergents and ontogenesis. The major binding site (a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)90211-7
更新日期：1979-04-27 00:00:00
abstract：:One model useful for demonstrating axonal regeneration in the central nervous system is that in which peripheral tissue, particularly the iris, is implanted into the brain or spinal cord. The aim of the present study was to establish the origin of some of the regenerating fibers by the use of an autoradiograhic tracin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(80)91121-x
更新日期：1980-09-22 00:00:00
abstract：:The analgesic effect of clonidine in spontaneously hypertensive rats (SHR) and in normotensive Sprague-Dawley (SD) rats was assessed by using the formalin pain test. The analgesic response of SD rats to low doses (15-60 micrograms/kg i.p.) but not to a high dose (150 micrograms/kg i.p.) of clonidine was inhibited by n...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91630-2
更新日期：1989-02-13 00:00:00
abstract：:Discrete axon-sparing lesions were placed unilaterally in the mesencephalon by the local injection of kainic acid. Unilateral lesions of the dorsal reticular formation just beneath the superior colliculus and lateral to the periacqueductal grey resulted in consistent ipsiversive apomorphine-induced circling. Only weak...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90579-5
更新日期：1981-03-16 00:00:00
abstract：:A novel RNA-mediated disease mechanism has emerged from studies on dominantly inherited neurological disorders caused by unstable microsatellite expansions in non-coding regions of the genome. These non-coding tandem repeat expansions trigger the production of unusual RNAs that gain a toxic function, which involves th...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.03.039
更新日期：2014-10-10 00:00:00
abstract：:Rats exposed to stressors that cannot be controlled may develop a deficit in their ability to subsequently learn to control a new stressor. This phenomenon is known as 'learned helplessness' and is a well-accepted animal model of depression. Evidence is presented showing that rats having different directional biases o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91335-x
更新日期：1991-06-07 00:00:00
abstract：:Putative serotonergic dorsal raphe (DRN) neurons display a dramatic state-related change in behaviour, discharging regularly at a high rate during waking and at progressively slower rates during slow-wave sleep (SWS) and ceasing firing during paradoxical sleep (PS). Using the antidromic latency technique and extracell...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02210-7
更新日期：2001-04-20 00:00:00
abstract：:We examined the effect of nitric oxide (NO) on the expression of phosphorylated cAMP response element binding (pCREB) protein and on the polysialylated form of the neural cell adhesion molecule (PSA-NCAM), in the hippocampus of the adult rat, by administering 7-nitroindazole (7-NI) for 5 days, to block neuronal nitric...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.01.055
更新日期：2004-05-15 00:00:00
