Modification of the responses of primate spinothalamic neurons to mechanical stimulation by excitatory amino acids and an N-methyl-D-aspartate antagonist.


:Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on the discharges evoked in nociceptive primate spinothalamic tract (STT) neurons by mechanical stimulation of the skin. Responses to innocuous brushing of the skin were facilitated by GLUT and NMDA (and in some neurons by QUIS) and sometimes reduced by AP-7. GLUT also facilitated the responses to noxious mechanical stimuli. The results are consistent with anatomical evidence for the presence of synapses that contain EAAs on primate STT cells and with the proposal that the co-release of EAAs and neuropeptides may contribute to hyperalgesia.


Brain Res


Brain research


Dougherty PM,Willis WD




Has Abstract


1991-02-22 00:00:00














  • Effect of MK-801 on the induction and subsequent decay of long-term potentiation in the unanesthetized rabbit hippocampal dentate gyrus.

    abstract::Several investigations have shown that the N-methyl-D-aspartate (NMDA) antagonist MK-801 interferes both with learning and a candidate neural mechanism for learning, the long-term potentiation (LTP) phenomenon. The low doses of MK-801 reported to block learning, however, may not be sufficient to block LTP. The present...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Robinson GB,Reed GD

    更新日期:1992-01-08 00:00:00

  • LPS-induced Fos expression in oxytocin and vasopressin neurons of the rat hypothalamus.

    abstract::The aim of this study was to examine the involvement of the hypothalamic oxytocin (OXT) and vasopressin (AVP) neurons in acute phase reaction using quantitative dual-labeled immunostaining with Fos and either OXT and AVP in several hypothalamic regions. Administration of low dose (5 microg/kg) and high dose (125 micro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Matsunaga W,Miyata S,Takamata A,Bun H,Nakashima T,Kiyohara T

    更新日期:2000-03-06 00:00:00

  • Visuospatial learning impairment following lesion of the cholinergic projection to the hippocampus.

    abstract::Ibotenic acid lesions of the vertical limb of the diagonal band of Broca (VDB) in marmosets produced significant depletions in choline acetyltransferase (ChAT) activity and a decrease in acetylcholinesterase (AChE) staining in the hippocampal formation and entorhinal cortex (to which the cholinergic neurones of the VD...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Ridley RM,Samson NA,Baker HF,Johnson JA

    更新日期:1988-07-19 00:00:00

  • Reduced cell proliferation and increased apoptosis in the hippocampal formation in a rat model of Hirschsprung's disease.

    abstract::Hirschsprung's disease (HSCR) is a congenital malformation characterized by the absence of enteric ganglia in the distal intestine and gut obstruction. Some HSCR patients also have associated neurological symptoms. We studied a rat model of HSCR, also known as spotting lethal (sl/sl) rat, which carries a spontaneous d...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Xie D,Croaker GDH,Li J,Song ZM

    更新日期:2016-07-01 00:00:00

  • A type of basket cell in superficial layers of the cat visual cortex. A Golgi-electron microscope study.

    abstract::The axonal arborizations of the basket cells in the cerebral neocortex have long been considered as the source of the presynaptic terminals contacting the cell bodies of pyramidal cells. Given that the concept of the cortical basket cell is based upon indirect evidence only, it was deemed worthwhile to re-investigate ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: DeFelipe J,Fairén A

    更新日期:1982-07-22 00:00:00

  • Neuroprotection against excitotoxic brain injury in mice after ovarian steroid depletion.

    abstract::Ovarian steroid hormones influence not only seizure phenomena, but also the neuronal cell death that follows. In the present study, we applied two models of ovarian steroid loss, ovariectomy and chemically-induced ovarian failure, to evaluate kainate-induced seizure activity and the susceptibility of hippocampal neuro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schauwecker PE,Wood RI,Lorenzana A

    更新日期:2009-04-10 00:00:00

  • Long-term enhancement of entorhinal-dentate evoked potentials following 'modified' ECS in the rat.

    abstract::Electroconvulsive therapy (ECT) is widely used as a treatment for drug-resistant depression. The animal analogue of ECT is electroconvulsive shock (ECS) seizures. We have recently shown that repeated ECS seizures cause a long-lasting, perhaps permanent, enhancement in entorhinal-dentate evoked potentials in the rat. O...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gombos Z,Mendonça A,Racine RJ,Cottrell GA,Burnham WM

    更新日期:1997-08-22 00:00:00

  • Ultrastructure of supraspinal dorsal root projections in the toads. I. The obex region.

    abstract::The ultrastructure of the dorsal column nucleus (DCN) has been investigated at the level of the obex region in normal and experimental toads. Large 'isolated' neurons (greater than 20 micrometer) and clusters of small neurons (less than 20 micrometer) have been identified in this region. Synaptic profiles have been cl...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Corvaja N,Pellegrini M,Buisseret-Delmas C

    更新日期:1978-03-10 00:00:00

  • Remote astrocytic response of prefrontal cortex is caused by the lesions in the nucleus basalis of Meynert, but not in the ventral tegmental area.

    abstract::The nucleus basalis of Meynert (nbM) was lesioned by injection of ibotenic acid, in 200 g male Wistar rats. The rats were killed 1, 3, 7 or 21 days after surgery, the brains were removed and the prefrontal cortices were subjected to immunohistochemical and Western blot analysis for the expression of glial fibrillary a...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Anezaki T,Yanagisawa K,Takahashi H,Nakajima T,Miyashita K,Ishikawa A,Ikuta F,Miyatake T

    更新日期:1992-03-06 00:00:00

  • The effect of acute citalopram on extracellular 5-HT levels is not augmented by lithium: an in vivo microdialysis study.

    abstract::A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentative strategy. Since lithium has been demonstrated to affect 5-HT neurotransmission, we examined the effect of acute and subchronic lithium on 5-HT levels after a challen...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Wegener G,Linnet K,Rosenberg R,Mørk A

    更新日期:2000-07-21 00:00:00

  • Daily rhythms of cognition-related factors are modified in an experimental model of Alzheimer's disease.

    abstract::The accumulation of amyloid-β (Aβ) peptides in the brain of Alzheimer disease patients is associated to cognitive deficit, increased oxidative stress, and alterations in the circadian rhythms. Brain-derived neurotrophic factor (BDNF) and Neurogranin (RC3), play an important role in the synaptic plasticity underlying m...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Navigatore-Fonzo L,Castro A,Pignataro V,Garraza M,Casais M,Anzulovich AC

    更新日期:2017-04-01 00:00:00

  • Mechanisms of anoxia-induced depolarization in brainstem neurons: in vitro current and voltage clamp studies in the adult rat.

    abstract::To determine the mechanisms underlying the depolarization induced by anoxia in brainstem neurons, we studied single neurons in brainstem slices using conventional micro-electrodes and freshly dissociated hypoglossal and vagal cells using patch clamp techniques (whole-cell configuration). Since glutamate concentration ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haddad GG,Jiang C

    更新日期:1993-10-22 00:00:00

  • Identification of MSH release-inhibiting elements in the neurointermediate lobe of the rat.

    abstract::Neurointermediate lobes of rats comprise elements which, when excited in vitro, bring about an inhibition of the release of melanocyte stimulating hormone (MSH). Superfusion of neurointermediate lobes of intact donor rats with medium containing 45 mM K+ induced a stimulation of the release of oxytocin, arginine-vasopr...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Tilders FJ,van der Woude HA,Swaab DF,Mulder AH

    更新日期:1979-08-10 00:00:00

  • Relations between the directions of vibration-induced kinesthetic illusions and the pattern of activation of antagonist muscles.

    abstract::In humans, tendon vibration evokes illusory sensations of movement that are usually associated with an excitatory tonic response in muscles antagonistic to those vibrated (antagonist vibratory response, AVR), i.e., in the muscle groups normally contracted if the illusory movement had been performed. The aim of the pre...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Calvin-Figuière S,Romaiguère P,Roll JP

    更新日期:2000-10-27 00:00:00

  • Afferent projections to the orbicularis oculi motoneuronal cell group. An autoradiographical tracing study in the cat.

    abstract::The motoneurons innervating the orbicularis oculi muscle from a subgroup within the facial nucleus, called the intermediate facial subnucleus. This makes it possible to study afferents to these motoneurons by means of autoradiographical tracing techniques. Many different injections were made in the brainstem and dienc...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Holstege G,van Ham JJ,Tan J

    更新日期:1986-05-28 00:00:00

  • Ascending reticular activating system in the rat: a 2-deoxyglucose study.

    abstract::The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map ascending pathways which are influenced by arousing electrical stimulation of the midbrain reticular formation (RET) in alert rats. The major finding was that RET stimulation produces selective patterns of metabolic activation and suppression in di...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Gonzalez-Lima F,Scheich H

    更新日期:1985-09-30 00:00:00

  • Kappa-bungarotoxin blocks an alpha-bungarotoxin-sensitive nicotinic receptor in the insect central nervous system.

    abstract::Snake venom kappa-neurotoxins are selective antagonists of nicotinic acetylcholine responses in avian, murine and bovine neurons, and have been used as probes for functionally defined vertebrate neuronal nicotinic receptors. The actions of kappa-bungarotoxin, a kappa-neurotoxin, have now been examined at a central inv...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Pinnock RD,Lummis SC,Chiappinelli VA,Sattelle DB

    更新日期:1988-08-16 00:00:00

  • Glucose administration after traumatic brain injury exerts some benefits and no adverse effects on behavioral and histological outcomes.

    abstract::The impact of hyperglycemia after traumatic brain injury (TBI), and even the administration of glucose-containing solutions to head injured patients, remains controversial. In the current study adult male Sprague-Dawley rats were tested on behavioral tasks and then underwent surgery to induce sham injury or unilateral...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shijo K,Ghavim S,Harris NG,Hovda DA,Sutton RL

    更新日期:2015-07-21 00:00:00

  • Effects of leptin on spinally projecting neurons in the PVN of the hypothalamus.

    abstract::The study examined whether intravenous (i.v.) leptin increased Fos-production in spinally projecting neurons in the hypothalamic paraventricular nucleus (PVN). We combined (i) rhodamine tagged microspheres injected into the upper thoracic spinal cord and (ii) Fos (marker of neuronal activation) immunohistochemistry. E...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Badoer E,Ryan A

    更新日期:1999-10-09 00:00:00

  • The re-establishment of synaptic transmission by regenerating optic axons in goldfish: time course and effects of blocking activity by intraocular injection of tetrodotoxin.

    abstract::Intraocular injections of tetrodotoxin were used to block activity for 27 days in normal fish and for the first 27 or 31 days of regeneration in fish with one optic nerve crushed. Synaptic activity was then assessed by a current source-density analysis of field potentials evoked by optic nerve shock at different times...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Schmidt JT,Edwards DL,Stuermer C

    更新日期:1983-06-13 00:00:00

  • Colocalization of D1 and D2 dopamine receptor mRNAs in striatal neurons.

    abstract::There is evidence that D1 and D2 dopamine receptor subtypes coexist at the cellular level in the striatum and act synergistically to mediate the effects of dopamine. Other data suggest that these receptor subtypes are largely segregated in different striatal projection pathways. We used in situ hybridization in serial...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Lester J,Fink S,Aronin N,DiFiglia M

    更新日期:1993-09-03 00:00:00

  • Phosphacan immunoreactivity is associated with perineuronal nets around parvalbumin-expressing neurones.

    abstract::A special feature of the extracellular matrix in adult brains of various species is the concentration of certain components around different sub-populations of neurones, giving rise to net-like structures termed perineuronal nets. Recently, some of these components have been identified but the function of these nets h...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Haunso A,Celio MR,Margolis RK,Menoud PA

    更新日期:1999-07-10 00:00:00

  • A deeper reanalysis of a superficial feature: an ERP study on agreement violations.

    abstract::A morphosyntactic agreement violation during reading elicits a well-documented biphasic ERP pattern (LAN+P600). The cognitive variables that affect both the amplitude of the two components and the topography of the anterior negativity are still debated. We studied the ERP correlates of the violation of a specific agre...

    journal_title:Brain research

    pub_type: 临床试验,杂志文章


    authors: Molinaro N,Vespignani F,Job R

    更新日期:2008-09-04 00:00:00

  • Cell division in the developing cat retina occurs in two zones.

    abstract::Cytogenesis in the kitten retina has been investigated with [3H]thymidine autoradiography and a stain for mitotic figures. The nuclei of cells in S-phase are located adjacent to the inner margin of the cytoblast layer, near the inner plexiform layer. The nuclei then migrate toward the outer limiting membrane (OLM) to ...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Robinson SR,Rapaport DH,Stone J

    更新日期:1985-03-01 00:00:00

  • Potassium chloride depolarization enhances MPP+-induced hydroxyl radical generation in the rat striatum.

    abstract::We determined that extracellular potassium ion concentration, [K+]o-induced depolarization, enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a micro...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Obata T,Aomine M,Yamanaka Y

    更新日期:2000-01-10 00:00:00

  • Salience, emotion, and attention: the neural networks underlying tinnitus distress revealed using music and rest.

    abstract::In the present study, we used an innovative music-rest interleaved fMRI paradigm to investigate the neural correlates of tinnitus distress. Tinnitus is a poorly-understood hearing disorder where individuals perceive sounds, in the absence of an external source. Although the great majority of individuals habituate to c...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Shahsavarani S,Schmidt SA,Khan RA,Tai Y,Husain FT

    更新日期:2021-01-07 00:00:00

  • The quantitative bioassay of nerve growth factor: use of frozen 'primed' PC12 pheochromocytoma cells.

    abstract::A quantitative bioassay for nerve growth factor (NGF) has been previously described which employs PC13 rat pheochromocytoma cells. The basis of this assay is that rapid neurite regeneration by PC12 cells pretreated ('primed') with NGF for at least a week is quantitatively related to the amount of NGF present in the cu...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Rukenstein A,Greene LA

    更新日期:1983-03-14 00:00:00

  • Melatonin attenuates neuronal NADPH-d/NOS expression in the hypoglossal nucleus of adult rats following peripheral nerve injury.

    abstract::Oxidative stress and massive production of nitric oxide (NO) have been implicated in the neuropathogenesis following peripheral nerve injury. This study was aimed to ascertain whether melatonin would exert its neuroprotective effect on the lesioned hypoglossal neurons after peripheral axotomy, since it is known to red...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Chang HM,Ling EA,Lue JH,Wen CY,Shieh JY

    更新日期:2000-08-11 00:00:00

  • Curve-shift analysis of self-stimulation in food-restricted rats: relationship between daily meal, plasma corticosterone and reward sensitization.

    abstract::Chronic food restriction lowers the threshold for lateral hypothalamic electrical self-stimulation (LHSS). This effect has previously been interpreted to reflect a sensitization of reward. In the present study a curve-shift method was used to explicitly differentiate effects of food restriction on brain stimulation re...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Abrahamsen GC,Berman Y,Carr KD

    更新日期:1995-10-16 00:00:00

  • Immunocytochemical study on the distribution of nitrotyrosine in the brain of the transgenic mice expressing a human Cu/Zn SOD mutation.

    abstract::In the previous study, we reported increased NOS expression in the astrocytes in the spinal cord of the transgenic mice that are used as ALS animal model. In the present study, we performed immunocytochemical studies to investigate the changes of nitrotyrosine-immunoreactivity in the brains of the transgenic mice, and...

    journal_title:Brain research

    pub_type: 杂志文章


    authors: Cha CI,Chung YH,Shin CM,Shin DH,Kim YS,Gurney ME,Lee KW

    更新日期:2000-01-17 00:00:00