Abstract：
:Excitatory amino acids (EAAs) are likely to play a key role in sensory transmission in the spinal cord. In the present study, the microiontophoresis technique was used to investigate the effects of L-glutamate (GLUT), N-methyl-D-aspartate (NMDA), and quisqualate (QUIS), as well as an NMDA receptor antagonist, AP-7, on the discharges evoked in nociceptive primate spinothalamic tract (STT) neurons by mechanical stimulation of the skin. Responses to innocuous brushing of the skin were facilitated by GLUT and NMDA (and in some neurons by QUIS) and sometimes reduced by AP-7. GLUT also facilitated the responses to noxious mechanical stimuli. The results are consistent with anatomical evidence for the presence of synapses that contain EAAs on primate STT cells and with the proposal that the co-release of EAAs and neuropeptides may contribute to hyperalgesia.
journal_name
Brain Resjournal_title
Brain researchauthors
Dougherty PM,Willis WDdoi
10.1016/0006-8993(91)90991-4subject
Has Abstractpub_date
1991-02-22 00:00:00pages
15-22issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(91)90991-4journal_volume
542pub_type
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