Abstract:
:The autoradiographic [14C]2-deoxyglucose (2-DG) method was used to map ascending pathways which are influenced by arousing electrical stimulation of the midbrain reticular formation (RET) in alert rats. The major finding was that RET stimulation produces selective patterns of metabolic activation and suppression in discrete brain regions. The regions activated were limited to specific intralaminar, medial and anterior thalamic nuclei, and to the entire auditory system. Conversely, a large suppression of 2-DG uptake was observed in most of the cerebral cortex, limbic and extrapyramidal structures, whereas at the same time some brain regions were left unaffected. Striking similarities were found between the functional pathways affected differentially by RET stimulation and well-defined cholinergic pathways which originate in the midbrain tegmentum. Structures which showed metabolic activation are part of the dorsal cholinergic pathway, whereas the regions suppressed are part of the ventral cholinergic pathway and its higher-order projections. The results support the conclusion that cholinergic pathways represent the thalamic and extrathalamic divisions of the reticular activating system. Our observations provide the first anatomical demonstration that RET stimulation has widespread and differential effects on cerebral metabolism. They also support the concept that arousing electrocortical desynchronization involves reticular activation of thalamocortical neurons, which in turn have widespread suppressive influences on cortical metabolism.
journal_name
Brain Resjournal_title
Brain researchauthors
Gonzalez-Lima F,Scheich Hdoi
10.1016/0006-8993(85)91190-4subject
Has Abstractpub_date
1985-09-30 00:00:00pages
70-88issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(85)91190-4journal_volume
344pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::The localization of [3H]corticosterone in the brain and pituitary of the adrenalectomized rat was studied by autoradiography. Corticosterone was concentrated preferentially by neurons in the hippocampus, septum, amygdala, and neocortex, with the hippocampal and septal neurons having the greatest concentration. [3H]-Co...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(75)90937-3
更新日期:1975-01-10 00:00:00
abstract::The actions of sodium valproate (NaVP) were studied in the in vitro hippocampus using extracellular, intracellular and voltage-clamp recording techniques. In the CA1 region, concentrations of 30-200 microM NaVP reduced the amplitude but not the time course of post-tetanic potentiation (PTP) of dendritic field excitato...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90678-6
更新日期:1988-11-22 00:00:00
abstract::To test the hypothesis that functional metabolic deficits observed following surgical brain injury are associated with changes in cognitive performance in rodents, we performed serial imaging studies in parallel with behavioral measures in control animals and in animals with surgical implants. Memory function was asse...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.01.134
更新日期:2007-05-04 00:00:00
abstract::Previous parkinsonian rat models have utilized stereotactic 6-OHDA injections to completely lesion the dopaminergic mesostriatal system on one side. Recently, hemiparkinsonian rat models in which the mesolimbic system is left intact have been developed. The selective, partial lesion models better mimic the neuropathol...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)91533-4
更新日期:1994-01-07 00:00:00
abstract::Although the role of cAMP-response-element-binding protein (CREB) binding protein (CBP) in the neuroprotective mechanisms has been the focus of many studies, very little is known about the expression or function of CBP in aged brains. We have therefore examined age-related changes in CBP expression in the cerebral cor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03562-x
更新日期:2002-11-29 00:00:00
abstract::The retrograde transport of fluorescent substances was used in order to investigate divergent axon collaterals of neurons in the nucleus prepositus hypoglossi (Ph). Fast blue (FB) was injected into the flocculus, paraflocculus and/or the vermis, while nuclear yellow (NY) was injected into the oculomotor nucleus alone ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90150-0
更新日期:1982-08-19 00:00:00
abstract::Hormone-dependent sociosexual behaviors of the displaying individual regulate the abundance of estrogen receptor- and progesterone receptor-mRNA in sex steroid hormone-concentrating brain areas of the partner. This effect of behavior on gene expression in the brain is independent of the gonads. ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(96)01087-6
更新日期:1996-11-25 00:00:00
abstract::The effect of the protein kinase C enzyme inhibitor H-7 was examined on the brain edema formation evoked by bilateral occlusion of the common carotid arteries in Sprague-Dawley rats of CFY strain. Brain edema was assessed by measurement of water and electrolyte contents of the brain. The results showed that pretreatme...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)90439-3
更新日期:1989-06-19 00:00:00
abstract::Systemic administration of mesenchymal stem cells (MSCs) following cerebral infarction exerts functional improvements. Previous research has suggested potential therapeutic mechanisms that promote neuroprotection and synaptogenesis. These include secretion of neurotrophic factors, remodeling of neural circuits, restor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.05.033
更新日期:2018-09-15 00:00:00
abstract::Auditory transients (such as sound onset or a frequency transition within a continuous sound) are assumed to parse the auditory input into smaller units enabling the formation of unitary sound representations separately for each segment. This was discovered by using the mismatch negativity (MMN) component of the event...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.04.046
更新日期:2012-06-29 00:00:00
abstract::Previous immunocytochemical, physiological, and molecular studies have reported that the Syrian hamster lacks a shortwave-sensitive (S) cone photopigment but retains circadian responses to ultraviolet (UV) light. Using opsin antibodies and a sensitive detection protocol, we here show that S opsin immunoreactivity colo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)02267-9
更新日期:2002-03-01 00:00:00
abstract::Rats reared on a diet in which choline is replaced with N-aminodeanol (NADE), undergo > 50% replacement of brain acetylcholine with acetylated NADE, a false cholinergic transmitter. We examined amounts of sleep and wakefulness in 7 littermate pairs of rats fed either NADE-substituted, or a choline control diet for > 1...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90492-6
更新日期:1993-11-26 00:00:00
abstract::Spontaneous hippocampal EEG activity and evoked field potentials were investigated in intact rats and in animals with fetal hippocampal grafts. Pieces of hippocampal grafts, derived from 15- to 16-day-old fetuses, were used to prepare cell suspensions and grafted directly into the intact hippocampus. Control animals r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90168-u
更新日期:1991-07-19 00:00:00
abstract::Bilateral intranigral administration of the selective NK-1 tachykinin receptor agonist [AcArg6, Sar9, Met(O2)11]SP6-11 (0-1 nmol total bilateral dose) selectively induced grooming in rats. This response was blocked by concurrent intranigral administration of the NK-1 tachykinin receptor antagonist RP 67580 (2 nmol), b...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00940-r
更新日期:1995-11-27 00:00:00
abstract::Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(02)03178-5
更新日期:2002-10-04 00:00:00
abstract::Immunohistochemical and retrograde tracing techniques were combined to demonstrate the occurrence of displaced ganglion cells (DGCs) exhibiting substance P-like immunoreactivity (SP-LI) in the pigeon retina. Following injections of rhodamine-labeled latex microspheres into the nucleus of the basal optic root (accessor...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91159-x
更新日期:1991-04-12 00:00:00
abstract::The present study aimed to evaluate the therapeutic potential of apocynin, an NADPH oxidase assembly inhibitor, on traumatic brain injury. Rat traumatic brain injury (TBI) was performed using a weight drop model. Apocynin (100mg/kg) was injected into the intraperitoneal space 15 min before TBI. Reactive oxygen species...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2012.08.032
更新日期:2012-10-24 00:00:00
abstract::The effects of selective axotomy of serotoninergic neurons produced by an intracerebroventricular injection of 5,7-dihydroxytryptamine (200 micrograms free base) on 5-HT1B binding sites labeled with S-CM-G-[125I]TNH2 were investigated by quantitative autoradiography in the rat brain. Results show, 21 days after surger...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91452-x
更新日期:1993-10-01 00:00:00
abstract::Prefrontal impairments have been hypothesized to be most strongly associated with the cognitive and emotional dysfunction in depression. Recently, white matter microstructural abnormalities in prefrontal lobe have been reported in elderly patients with major depressive disorder (MDD) using diffusion tensor imaging (DT...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.06.094
更新日期:2007-09-07 00:00:00
abstract::Using a dual-serial-arithmetic paradigm, we examined whether a capacity limitation constrains the neural activation that underlies dual-task performance. Six conditions were run in the experiment (the baseline, single-addition, single-subtraction, dual-addition, dual-subtraction, and the dual-operation condition). In ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.12.070
更新日期:2008-03-14 00:00:00
abstract:BACKGROUND:Inflammatory damage aggravates the cerebral ischemic pathological process and may pave a new way for treatment. Bicyclol has been proved to elicit a series of biologic effects through its anti-inflammatory property in treating hepatitis and hepatic ischemic/reperfusion injury. Whether this protective effect ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.06.032
更新日期:2013-08-28 00:00:00
abstract::The lateral geniculate nucleus (LGN) of a fetal rat was transplanted to the visual cortex (VC) of a neonatal rat. A current source-density analysis of field potentials and an intracellular study of neuronal responses were conducted in slice preparations by electrical stimulation of transplanted LGN and host VC. The re...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)90554-3
更新日期:1987-09-29 00:00:00
abstract::Mapping studies with central drug injections in the hungry rat have identified the perifornical lateral hypothalamus as being uniquely sensitive to the feeding suppressive effects of exogenous dopamine, as well as anorexic drugs which release endogenous catecholamines. In the present study, the hypothalamic dopamine-r...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(79)90899-0
更新日期:1979-08-17 00:00:00
abstract::Tactile stimulation of the body surface elicited climbing fiber responses in 5% of the 839 Purkinje cells recorded in the caudal posterior vermis (lobules VII-IX) of cats anesthetized with sodium pentobarbital. The cells responsive to tactile stimulation were mainly encountered around the prepyramidal fissure between ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(90)90084-o
更新日期:1990-06-11 00:00:00
abstract::The distribution of carnosine-like immunoreactivity in photoreceptors of the frog retina was studied by post-embedding electron microscope immunocytochemistry. Different fixation and embedding procedures were applied and the best results were achieved on sections from tissue embedded in the hydrophilic resin LR White....
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)90256-9
更新日期:1992-04-24 00:00:00
abstract::Repeated cocaine exposure alters medial prefrontal cortex (mPFC) function to allow for enhanced excitatory transmission to the nucleus accumbens and ventral tegmental area (VTA). Previous studies have demonstrated changes in receptor function in the mPFC in animals repeatedly exposed to cocaine that produced increased...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2018.07.029
更新日期:2018-11-01 00:00:00
abstract::Neurotensin (NT), a tridecapeptide, is a neurotransmitter that elicits potent effects including hypothermia and antinociception in mice and rats. To date, there are two types of the neurotensin receptor (NTR) that have been molecularly cloned from the rat. However, several lines of evidence suggest the presence of add...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00150-4
更新日期:1998-05-11 00:00:00
abstract::The resurgent Na(+) current (I(NaR)) is a component of neuronal voltage-dependent Na(+) currents that is activated by repolarization and is believed to result from an atypical path of Na(+)-channel recovery from inactivation. So far, I(NaR) has only been identified in a small number of central neuronal populations in ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2007.05.065
更新日期:2007-08-13 00:00:00
abstract::Many AIDS patients suffer from cognitive impairments including deficits in learning and memory. The Human Immunodeficiency Virus-1 (HIV-1) envelope glycoprotein gp120 is one possible mediator of these impairments. This is because gp120 activates brain microglial cells and astrocytes, and in vivo activation of glia lea...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02445-2
更新日期:2000-04-07 00:00:00
abstract::Relative preservation of dopaminergic axons in patches and a subcallosal layer was observed in the dorsal, lateral and caudal striatum 4 weeks after intrastriatal injection of 6-hydroxydopamine (6-OHDA), a neurotoxin selective for catecholaminergic neurons. Since calcium binding proteins are reported to provide neurop...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(00)02219-8
更新日期:2000-06-02 00:00:00