Sleep-wake disturbances in an animal model of chronic cholinergic insufficiency.

Abstract:

:Rats reared on a diet in which choline is replaced with N-aminodeanol (NADE), undergo > 50% replacement of brain acetylcholine with acetylated NADE, a false cholinergic transmitter. We examined amounts of sleep and wakefulness in 7 littermate pairs of rats fed either NADE-substituted, or a choline control diet for > 100 days after weaning. During the lights-on portion of the 12/12 h light/dark cycle, NADE rats spent more time awake, and less time in both non-REM and REM sleep compared to littermate controls. Average durations of waking episodes were significantly increased in NADE rats. During the 12 h dark period, there were no between-group differences in sleep-waking amounts. Behavioral hyper-responsiveness which interferes with sleep onset, combined with reduced activity in brainstem cholinergic mechanisms involved in REM sleep generation may underlie daytime sleep-waking disturbances in NADE rats.

journal_name

Brain Res

journal_title

Brain research

authors

Szymusiak R,McGinty D,Fairchild MD,Jenden DJ

doi

10.1016/0006-8993(93)90492-6

subject

Has Abstract

pub_date

1993-11-26 00:00:00

pages

141-5

issue

1

eissn

0006-8993

issn

1872-6240

pii

0006-8993(93)90492-6

journal_volume

629

pub_type

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