Tumor necrosis factor-alpha inhibits physiologically identified dorsal motor nucleus neurons in vivo.

Abstract:

:Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric distention. A large majority of physiologically identified DMN neurons are rapidly and completely inhibited by exposure to TNF-alpha, suggesting that TNF-alpha may induce gastric stasis by functioning as a hormone that modulates both portions of this reflex pathway during illness.

journal_name

Brain Res

journal_title

Brain research

authors

Emch GS,Hermann GE,Rogers RC

doi

10.1016/s0006-8993(02)03178-5

subject

Has Abstract

pub_date

2002-10-04 00:00:00

pages

311-5

issue

2

eissn

0006-8993

issn

1872-6240

pii

S0006899302031785

journal_volume

951

pub_type

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