Abstract:
:Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric distention. A large majority of physiologically identified DMN neurons are rapidly and completely inhibited by exposure to TNF-alpha, suggesting that TNF-alpha may induce gastric stasis by functioning as a hormone that modulates both portions of this reflex pathway during illness.
journal_name
Brain Resjournal_title
Brain researchauthors
Emch GS,Hermann GE,Rogers RCdoi
10.1016/s0006-8993(02)03178-5subject
Has Abstractpub_date
2002-10-04 00:00:00pages
311-5issue
2eissn
0006-8993issn
1872-6240pii
S0006899302031785journal_volume
951pub_type
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