Inhibition by H-7 of the protein kinase C prevents formation of brain edema in Sprague-Dawley CFY rats.

abstract：:Fluorescence and immunohistochemical techniques were used to study the pattern and density of perivascular nerves containing noradrenaline (NA) and neuropeptide Y (NPY) supplying the major cerebral arteries of 4-, 6-, 8- and 12-week-old spontaneously hypertensive rats (SHR) and normotensive Wistar (WIS) controls. Leve...

journal_title：Brain research

authors： Dhital KK,Gerli R,Lincoln J,Milner P,Tanganelli P,Weber G,Fruschelli C,Burnstock G

更新日期：1988-03-15 00:00:00

abstract：:We recently reported raphe neurones which frequently fired spikes in short bursts. However, the action potentials were broad and the neurones fired in a slow and regular pattern, suggesting they were an unusual type of 5-hydroxytryptamine (5-HT) neurone. In the present study, we investigated whether these putative bur...

journal_title：Brain research

authors： Hajós M,Sharp T

更新日期：1996-11-18 00:00:00

abstract：:In rats under urethane, iontophoretic applications of GABA (30-60 nA) in the str. pyramidale of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale...

journal_title：Brain research

authors： Dalkara T

更新日期：1986-02-26 00:00:00

abstract：:Newly synthesized serotonin (5-HT) can be released in the nodose ganglion from the nerve cell bodies of vago-aortic serotoninergic neurones. Free-calcium led to a decrease of spontaneous and potassium-evoked release. The veratridine-stimulating response was abolished by TTX. The concept that 5-HT released from perikar...

journal_title：Brain research

authors： Fueri C,Faudon M,Hery M,Hery F

更新日期：1984-06-18 00:00:00

abstract：:ENT1 is an equilibrative nucleoside transporter that enables trans-membrane bi-directional diffusion of biologically active purines such as adenosine. In spinal cord dorsal horn and in sensory afferent neurons, adenosine acts as a neuromodulator with complex pro- and anti-nociceptive actions. Although uptake and relea...

journal_title：Brain research

authors： Governo RJ,Deuchars J,Baldwin SA,King AE

更新日期：2005-10-19 00:00:00

abstract：:Following microinjections of a colloidal gold complex into the nucleus paragigantocellularis (PGi) of the ventral medulla, and of latex microspheres into the nucleus abducens (Abd) of the same animal, retrogradely labeled neurons were identified in the region of the contralateral supraoculomotor nucleus (SOM) in the v...

journal_title：Brain research

authors： Van Bockstaele EJ,Aston-Jones G

更新日期：1992-03-27 00:00:00

abstract：:The optic nerve of anesthetized cats was completely cut and the autologous sciatic nerve was transplanted. Sixty days later some populations of retinal ganglion cells were shown to regenerate the axon with retrograde HRP labeling. We verified that ganglion cells that had projected to the lateral geniculate nucleus (LG...

journal_title：Brain research

authors： Watanabe M,Sawai H,Fukuda Y

更新日期：1991-09-27 00:00:00

abstract：:An object recognition task was used to determine if chronic restraint stress (6 h/day for 21 days) impairs non-spatial memory, since chronic restraint is known to impair spatial memory. In addition, food deprivation was tested as a possible modulating factor of any stress effect in this non-reward-dependent task. Foll...

journal_title：Brain research

authors： Beck KD,Luine VN

更新日期：1999-05-29 00:00:00

abstract：:Retrograde transport of horseradish peroxidase (HRP) was used to identify supraependymal neurons projecting to the pituitary gland in the hamster. Supraependymal neurons overlying the median eminence were labeled by HRP injections into the neural and intermediate lobes of the pituitary gland; no neurons were labeled f...

journal_title：Brain research

authors： Michael DB,Hazlett JC,Mitchell JA

更新日期：1989-01-30 00:00:00

abstract：:A study was made of the effects of electrochemically stimulating (ECS) and destroying the midbrain dorsal and median raphe nuclei on the estrogen-progesterone- (EP) induced surge of pituitary LH release in ovariectomized rats. ECS and lesions were produced simultaneously with anodal direct current through a chronicall...

journal_title：Brain research

authors： Waloch M,Gilman D,Whitmoyer D,Sawyer CH

更新日期：1981-08-03 00:00:00

abstract：:In order to characterize the neurons responsible for ACTH release and the suppression produced by adrenocortical steroids, we have studied the pharmacological sensitivity of neurons in the region containing the highest concentration of corticotropin releasing factor (CRF) in the brain and probably responsible for most...

journal_title：Brain research

authors： Mandelbrod I,Feldman S,Werman R

更新日期：1983-08-01 00:00:00

abstract：:Insulin-like 6 immunoreactivity (irINSL6) was detected in Leydig cells of the mouse testis. In the brain, labeled somata were detected mainly in the caudal hypothalamus and midbrain. Double labeling the brainstem sections revealed that irINSL6 somata were 5-hydroxytryptamine (5-HT) positive. The presence of irINSL6 in...

journal_title：Brain research

authors： Brailoiu GC,Dun SL,Yin D,Yang J,Chang JK,Dun NJ

更新日期：2005-04-08 00:00:00

abstract：:The intracellular localization of the serine protease plasminogen activator was analyzed in homogenates of bovine brain cortex using differential fractionation procedures. The distribution of the enzyme was clearly different from that of cytosol and mitochondrial markers, and was similar to that of plasma membrane pro...

journal_title：Brain research

authors： Zisapel N,Miskin R,Laudon M,Soreq H

更新日期：1982-09-23 00:00:00

abstract：:To determine the effects of nerve injury on Fos expression, temporal and spatial distributions of Fos-positive neurons in the trigeminal nucleus caudalis were examined after tissue injury for isolation of the infraorbital nerve as controls and transection of this nerve as well as noxious chemical stimulation by formal...

journal_title：Brain research

authors： Terayama R,Nagamatsu N,Ikeda T,Nakamura T,Rahman OI,Sakoda S,Shiba R,Nishimori T

更新日期：1997-09-12 00:00:00

abstract：:The molecular mechanisms regulating the retrograde axonal transport of nerve growth factor (NGF) are currently unknown. This study identifies some of the signalling events involved. The phosphoinositide 3-kinase (PI3-kinase) inhibitor wortmannin (1 nmol/eye) irreversibly inhibits the amount of 125I-betaNGF retrogradel...

journal_title：Brain research

authors： Reynolds AJ,Bartlett SE,Hendry IA

更新日期：1998-07-06 00:00:00

abstract：:This study examined whether cardiac beta-adrenoceptor (beta-AR) function was altered in conscious rats with lesions surrounding the anteroventral third ventricle (AV3V). The findings were: (1) beta(1,2)-AR-mediated tachycardia was similar in sham and AV3V-lesion rats, (2) beta(3)- and/or atypical beta-AR-mediated tach...

journal_title：Brain research

authors： Whalen EJ,Schoorlemmer GH,Beltz TG,Johnson AK,Lewis SJ

更新日期：2001-09-14 00:00:00

abstract：:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tiss...

journal_title：Brain research

authors： Ritter S,Dinh TT

更新日期：1986-04-09 00:00:00

abstract：:Propofol is an intravenous anesthetic with neuroprotective effects against cerebral ischemia-reperfusion (I/R) injury. Few studies regarding the neuroprotective and neurobehavioral effects of propofol have been conducted, and the underlying mechanisms are still unclear. Because I/R may result in neuronal apoptosis, th...

journal_title：Brain research

authors： Xi HJ,Zhang TH,Tao T,Song CY,Lu SJ,Cui XG,Yue ZY

更新日期：2011-09-02 00:00:00

abstract：:Intracerebral hemorrhage (ICH) is a devastating stroke with no clinically proven treatment. Deferoxamine (DFX), an iron chelator, is a promising therapy that lessens edema, mitigates peri-hematoma cell death, and improves behavioral recovery after whole-blood-induced ICH in rodents. In this model, blood is directly in...

journal_title：Brain research

authors： Warkentin LM,Auriat AM,Wowk S,Colbourne F

更新日期：2010-01-14 00:00:00

abstract：:To determine the contribution by mast cells to the brain content of histamine (HA) and its metabolite tele-methylhistamine (t-MH), the number of mast cells, as well as the levels of HA and t-MH were measured in brain regions of mast cell-deficient (W/Wv) and control (+/+) mice. In agreement with earlier studies, mast ...

journal_title：Brain research

authors： Hough LB,Khandelwal JK,Goldschmidt RC,Diomande M,Glick SD

更新日期：1984-01-30 00:00:00

abstract：:The effects of selective dopamine antagonists on the pentazocine-like discriminative stimulus effects of morphine were investigated in the rat trained to discriminate 3.0 mg/kg of pentazocine from vehicle. Morphine (3.0 mg/kg), a mu-selective agonist, produced stimulus effects in common with pentazocine (3.0 mg/kg), i...

journal_title：Brain research

authors： Ukai M,Hiraiwa E,Kameyama T

更新日期：1991-02-08 00:00:00

abstract：:An isoindolin-1-one derivate, JM-1232(-), was recently developed as a sedative and hypnotic agent with a strong affinity for the central benzodiazepine binding site of gamma-aminobutyric acid(A) (GABA(A)) receptors. The purpose of this study was to examine the effects of JM-1232(-) on the cardiovascular and sympatheti...

journal_title：Brain research

authors： Shirasaka T,Kunitake T,Tsuneyoshi I

更新日期：2009-12-01 00:00:00

abstract：:The inhibitory effect of different concentrations of lithium (0.15-10 x 10(-3) M) on cAMP production induced by isoprenaline (1 x 10(-4) M) after the blockade of alpha(2)-adrenoceptors in the rat cerebral cortex was investigated. Low lithium concentrations (0.3-0.6 x 10(-3) M) exerted a significant inhibitory effect a...

journal_title：Brain research

authors： Laura Cuffi M,Carbonell L,Mármol F,Giménez J,Forn J

更新日期：2003-12-19 00:00:00

abstract：:The regulatory role of endothelins in cerebral microvessels was investigated in a recently developed model system which allows the study of small cerebral vessels in their normal microenvironment. Using brain slices of the rat neocortex, it was shown that the isopeptide endothelin-3 (ET-3) had no effect on cerebral mi...

journal_title：Brain research

authors： Sagher O,Jin Y,Thai QA,Fergus A,Kassell NF,Lee KS

更新日期：1994-09-26 00:00:00

abstract：:Large neurons in the neostriatum of patients with Alzheimer's disease (AD) and progressive supranuclear palsy (PSP) were investigated topographically, histologically and ultrastructurally. The number of large neurons whose nuclear area is greater than 101 microns2 was uniformly decreased in the neostriatum in PSP, but...

journal_title：Brain research

authors： Oyanagi K,Takahashi H,Wakabayashi K,Ikuta F

更新日期：1991-03-29 00:00:00

abstract：:The participation of glutamatergic circuits of the ventral basal ganglia in feeding-related regulatory mechanisms has been extensively indicated in primate and rodent species. In avian species, it has been shown that ICV injections of MK-801 or of CNQX increase food intake and reduce the latency of feeding initiation ...

journal_title：Brain research

authors： Da Silva AA,Marino-Neto J,Paschoalini MA

更新日期：2003-03-14 00:00:00

abstract：:Using a double-label immunofluorescence method, we analyzed the time course of the appearance of Fos and Jun in the nuclei of supraoptic nucleus (SON) neurons following intraperitoneal injection of hypertonic saline. Fos and Jun immunostaining appeared within 30 min, peaked at 90-120 min, and disappeared 4-5 h later. ...

journal_title：Brain research

authors： Wang K,Guldenaar SE,McCabe JT

更新日期：1997-01-23 00:00:00

abstract：:The actions of convulsant and sedative barbiturates on responses to gamma-aminobutyric acid (GABA) application and on inhibitory postsynaptic currents were compared using voltage-clamp techniques in cultured rat hippocampal neurons. The convulsant barbiturates, 5-ethyl-5-(3-methylbut-2-enyl) barbituric acid (3M2B), an...

journal_title：Brain research

authors： Holland KD,Canney DJ,Rothman SM,Ferrendelli JA,Covey DF

更新日期：1990-05-14 00:00:00

abstract：:During the middle of the subjective day, circadian activity rhythms in Syrian hamsters can be phase advanced by a variety of stimuli including microinjection of neuropeptide Y (NPY) or muscimol into the suprachiasmatic nucleus (SCN). It is not known, however, if these treatments shift activity rhythms by acting direct...

journal_title：Brain research

authors： Huhman KL,Marvel CL,Gillespie CF,Mintz EM,Albers HE

更新日期：1997-10-24 00:00:00

abstract：:Opioid receptor subtype antagonists differentially alter food intake under deprivation (24 h), glucoprivic (2-deoxy-D-glucose, 500 mg/kg, i.p.) or palatable (10% sucrose) conditions with mu (beta-funaltrexamine) and kappa (nor-binaltorphamine), but not delta1 ([D-Ala2,Leu5,Cys6]enkephalin) opioid antagonists reducing ...

journal_title：Brain research

authors： Ragnauth A,Ruegg H,Bodnar RJ

更新日期：1997-08-29 00:00:00