Abstract：
:Cross-sectional areas of the forebrain ventricles were measured from coronal sections in spontaneously hypertensive rats (SHRs) 4, 8, 12, 16, 21 and 56 weeks of age and in age-matched Wistar--Kyoto (WKY) and Sprague--Dawley (SD) normotensive rats. Progressive ventricular dilation and associated attrition of brain tissue was observed in SHRs of both sexes after 4 weeks of age, and was present in animals obtained from two different suppliers. In some SHRs, ventricle size was increased to 270% of control. Hence, it seems likely that some systemic and behavioral signs which are concomitant with hypertension in the SHR may be attributable to hydrocephalus and its neuropathological correlates.
journal_name
Brain Resjournal_title
Brain researchauthors
Ritter S,Dinh TTdoi
10.1016/0006-8993(86)90488-9subject
Has Abstractpub_date
1986-04-09 00:00:00pages
327-32issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(86)90488-9journal_volume
370pub_type
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