Abstract：
:The homozygous Brattleboro rat (di/di), displaying a hypothalamic form of diabetes insipidus, synthesizes a vasopressin (VP) precursor with an abnormal C-terminus. The phenotypic expression of coexisting peptides in mutant magnocellular VP cells shows a differential pattern. 7B2 is one of the peptides which is not detectable, whereas there is a clear galanin expression. During postnatal life a small but increasing number of solitary post-mitotic VP neurons of the di/di rat undergoes a switch to a heterozygous phenotype. Here we report the presence of 7B2 and galanin in these heterozygous cells, which suggests that for the expression of 7B2, but not for that of galanin, the relative amount of mutant VP precursor must be diminished. Possible underlying mechanisms for this differential phenotypic expression of coexisting peptides are compartmentalization of precursor synthesis within the RER or a competition for sites involved in the translocation of the functionally reduced RER.
journal_name
Brain Resjournal_title
Brain researchauthors
Gabreëls BA,Sonnemans MA,Seidah NG,Chrétien M,van Leeuwen FWdoi
10.1016/0006-8993(92)91218-4subject
Has Abstractpub_date
1992-07-10 00:00:00pages
275-82issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(92)91218-4journal_volume
585pub_type
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