Abstract：
:The roles of the dorsal and ventral hippocampus in fear and memory are unclear. This study examined the effects of temporary inactivation of the dorsal or ventral hippocampus on unconditioned and conditioned fear, using the shock-probe test. In Experiment 1, rats received either dorsal or ventral hippocampal infusions of lidocaine or saline, before exposure to an electrified shock-probe (acquisition I). In Experiment 2, rats received lidocaine or saline infusions after exposure to the shock-probe (acquisition II). In both experiments, a retention test in the same apparatus was given 24 h later, at which time the hippocampus was no longer inactivated, and the probe was disconnected from the shock-source. Because ventral hippocampal inactivation impaired fear behaviour during acquisition, and dorsal hippocampal inactivation impaired fear behaviour (probe avoidance) during retention, we concluded that 1) the ventral hippocampus plays a role in the expression of untrained fear reactions whereas 2) the dorsal hippocampus plays a role in encoding memory of the fearful experience.
journal_name
Brain Resjournal_title
Brain researchauthors
McEown K,Treit Ddoi
10.1016/j.brainres.2008.11.041subject
Has Abstractpub_date
2009-01-28 00:00:00pages
185-94eissn
0006-8993issn
1872-6240pii
S0006-8993(08)02810-2journal_volume
1251pub_type
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