Abstract：
:The lactating rat has been shown to lack a behavioral response and immediate early gene expression (cFos) in the hippocampus (Hipc) following intravenous or intracerebroventricular administration of an N-methyl-d-aspartate (NMDA) receptor agonist. The purpose of this study is to determine whether neurons in the Hipc have an intact postsynaptic NMDA receptor system. The presence of NMDA receptor protein was determined by Western blot analysis for the NR1, NR2A, and NR2B subunits. The presence of functional NMDA receptors in the Hipc was determined by behavioral responses and the expression of cFos immunoreactivity (-ir) in response to microinjection of an NMDA receptor agonist into the hilus of the dentate gyrus. No difference in NR1 and NR2A subunit protein in the Hipc was detected between the lactating and nonlactating rats. However, there was a 26% decrease in NR2B subunit protein in this region in the lactating rat. Lactating rats receiving NMA injections displayed hyperactive behavior, similar to that observed in the nonlactating animals receiving the same treatment. The lactating rat and the nonlactating rat also displayed equivalent bilateral cFos-ir in the dentate gyrus (DG), CA1 and CA3 regions of the Hipc in response to unilateral NMA injections into the Hipc. These data indicate that the lactating rat has an intact postsynaptic NMDA receptor system. Thus, Hipc refractoriness to peripheral and third ventricular injections of an NMDA receptor agonist may reflect inhibition of presynaptic input and glutamate release.
journal_name
Brain Resjournal_title
Brain researchauthors
Grove KL,Smith MSdoi
10.1016/s0006-8993(98)01069-5subject
Has Abstractpub_date
1998-12-14 00:00:00pages
157-63issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)01069-5journal_volume
814pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Veratridine-induced depolarization caused a large increase in Ca uptake in the rat hippocampal slice (30.2 vs. 9.0 nM/mg dry weight). This uptake was reduced to 18.4 nM/mg when veratridine was combined with anoxia. When compared with veratridine exposure alone, the combination of anoxia and veratridine increased intra...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91547-4
更新日期：1994-01-07 00:00:00
abstract：:Sex steroid hormones regulate various neural functions that control vertebrate sociosexual behavior. A number of sex steroids can be synthesized de novo in the brain, including estrogens by the enzyme aromatase. Aromatase, the neuropeptides arginine vasotocin/vasopressin, and the monoamine neurotransmitter dopamine ha...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.09.017
更新日期：2006-12-18 00:00:00
abstract：:We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine. The hypothesis was not supported; the pat...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)91126-6
更新日期：1994-06-20 00:00:00
abstract：:In this study we present data supporting a heterogeneous distribution of the brain-specific S-100 protein on nerve cell plasma membranes from isolated neurons. This has been shown in a previous study by immunoelectron microscopy using peroxidase-conjugated anti-S-100 antiserum and in this study by immunofluorescence u...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(75)90161-4
更新日期：1975-12-26 00:00:00
abstract：:Cyclooxygenase-2 (COX-2) is the predominant isoform of cyclooxygenase in brain. COX-2 activity produces oxidative stress and results in the production of prostaglandins that have many injurious effects. COX-2 transcription is induced by synaptic activity; therefore, COX-2 activity could contribute to epileptic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.05.038
更新日期：2005-07-19 00:00:00
abstract：:The putative neurotransmitter substance P was localized in the embryonic and neonatal mouse trigeminal nerve by indirect immunofluorescence. Central terminals in the nucleus caudalis gave a positive substance P-like immunofluorescence (SPLI) reaction of E13-E14. SPLI subsequently appeared in the peripheral mucous and ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90147-x
更新日期：1982-07-01 00:00:00
abstract：:The effects of ventromedial hypothalamic (VMH) stimulation on various metabolic parameters in freely moving animals were measured using a specific indirect calorimetric chamber associated with a quantitative measurement of locomotor activity, which allows the separate measurement of locomotor energy expenditure from t...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01922-8
更新日期：1999-10-30 00:00:00
abstract：:Increased and sustained central delivery of L-dihydroxyphenylalanine (L-DOPA) is a desirable therapeutic strategy in Parkinson's disease. We investigated the effects of peripheral catechol-O-methyltransferase (COMT) inhibition, by the non-toxic drug nitecapone on the metabolism of 6-[18F]fluoro-L-dihydroxyphenylalanin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90556-3
更新日期：1993-10-29 00:00:00
abstract：:Numerous studies have suggested that nitric oxide (NO) in the nucleus tractus solitarii (NTS) participates in modulating cardiovascular function. Nitric oxide synthase (NOS), the enzyme responsible for synthesis of NO, exists in 3 isoforms: endothelial NOS (eNOS), neuronal NOS (nNOS), and inducible NOS (iNOS). Althoug...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.07.057
更新日期：2007-09-26 00:00:00
abstract：:The localization of the two Ca-activated extralysosomal proteases m-calpain and mu-calpain in the eye of the adult rabbit was examined by immunohistochemistry, using poly- and monoclonal antibodies against the corresponding rabbit antigens. Immunoreactivity against the two forms of calpains was observed in the epithel...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)90513-m
更新日期：1993-05-21 00:00:00
abstract：:The effects of recombinant mouse stem cell factor (rmSCF) on paired-pulse facilitation (PPF) and long-term potentiation (LTP) in the mossy fiber (MF)-CA3 pathway were examined in mouse hippocampal slices by recording field EPSPs. When PPF was measured before and 30 min after tetanic stimulation, the initial PPF positi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02879-2
更新日期：2002-08-16 00:00:00
abstract：:Activities of individual, force-sensitive mechanoreceptors (funnel canal organs) of the terminal segment (dactyl) of the crab leg have been recorded in freely moving animals. During the stance phase of walking receptors discharge in regular bursts that are closely correlated with activity of the opener muscle of the p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90663-8
更新日期：1985-06-17 00:00:00
abstract：:In the vertebrate retina excitatory transmission seems to be mediated mainly by excitatory amino acids; glutamate and/or aspartate are the most viable candidates to subserve this function. Postsynaptic receptors for N-methyl-D-aspartate (NMDA), kainate (KA), quisqualate (QA) and 2-amino-4-phosphonobutyric acid have be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91330-8
更新日期：1987-06-23 00:00:00
abstract：:Cingulate cortex (CC) unit responses to hippocampal volleys and afterdischarges were studied in 4 awake unsedated squirrel monkeys using extracellular microelectrodes. Stimuli were delivered via bipolar electrodes chronically implanted bilaterally in anterior and posterior hippocampus. A total of 412 units in 21 track...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(83)91253-2
更新日期：1983-01-24 00:00:00
abstract：:The distribution and density of noradrenergic (NA) and serotonergic (5-HT) varicosities in the superior olive (SO) and periolivary region (PO) and their relationship to olivocochlear neurons was studied. Antibodies against 5-HT and the NA precursor enzyme dopamine beta-hydroxylase were utilized to examine the density ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01541-3
更新日期：1999-07-31 00:00:00
abstract：:The telencephalon of teleost fish shows high affinity uptake for D-[3H]aspartate, intermediate levels of GABAergic markers and low levels of cholinergic enzymes. Experimental results (resection of the olfactory tracts or unilateral kainic acid administration in the telencephalon) suggest that: the projection from the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)90823-6
更新日期：1985-10-07 00:00:00
abstract：:This study aimed at gaining insight into the role of the excitatory neurotransmitter glutamate in topographic map reorganization in the sensory systems of adult mammals after restricted deafferentations. Hereto, in vivo microdialysis was used to sample extracellular glutamate from sensory-deprived and non-deprived vis...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)04047-7
更新日期：2003-02-07 00:00:00
abstract：:Alcohol-preferring Alko, Alcohol (AA) rats with free access to food and water were taught to voluntarily consume 10% alcohol solution during 20-min sessions. After the drinking session, rats had elevated dopamine release (as reflected by 3-methoxytyramine concentrations) in the nucleus accumbens, olfactory tubercle, a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)81705-2
更新日期：1997-11-07 00:00:00
abstract：:Caspases, a family of cysteine proteases, are widely activated in neurons and glia in the injured brain, a response thought to induce apoptosis. However, caspase activation in astrocytes following injury is not strongly associated with apoptosis. The present study investigates the potential role of caspase activation ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.02.056
更新日期：2012-04-23 00:00:00
abstract：:To determine whether the sympathoexcitatory projection from the rostral ventrolateral medulla (RVL) to the sympathetic intermediolateral nucleus (IML) of the spinal cord might use glutamate as an excitatory transmitter, we performed a dual-label, transport and immunocytochemical ultrastructural study. Axon terminals w...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91196-8
更新日期：1991-10-18 00:00:00
abstract：:The dorsal root ganglia (DRG) have been identified as the target tissue in diabetic somatosensory neuropathy. It has been reported that, in the chronically diabetic state, DRG sensory neurons may undergo morphological changes. In this study, we examined the effect of zenarestat, an aldose reductase inhibitor, on the m...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.10.018
更新日期：2009-01-09 00:00:00
abstract：:Hyperactivity of the dopaminergic pathway is thought to contribute to clinical symptoms in the early stages of Huntington's disease (HD). It is suggested to be result of a reduced dopaminergic inhibition by degeneration of medium spiny neurons in the striatum. Previously, we have shown that the number of dopaminergic ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.01.041
更新日期：2019-06-01 00:00:00
abstract：:While exposure of cultured spinal neurons to mild hypothermia provides some protection from physical trauma (dendrotomy), profound cooling (< 17 degrees C) causes unrelated neuronal injury and death, which can be prevented by treatment with NMDA receptor antagonists. To investigate the mechanism of hypothermic neurona...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00726-7
更新日期：1995-09-18 00:00:00
abstract：:A substantial number of patients do not respond sufficiently to antidepressant drugs and are therefore often co-medicated with lithium as an augmentative strategy. Since lithium has been demonstrated to affect 5-HT neurotransmission, we examined the effect of acute and subchronic lithium on 5-HT levels after a challen...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02461-6
更新日期：2000-07-21 00:00:00
abstract：:The sometimes devastating mood swings of bipolar disorder are prevented by treatment with selected antiepileptic drugs, or with lithium. Abnormal membrane ion channel expression and excitability in brain neurons likely underlie bipolar disorder, but explaining therapeutic effects in these terms has faced an unresolved...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2010.07.021
更新日期：2010-09-17 00:00:00
abstract：:The effects of streptozotocin-induced diabetes mellitus on the activity of discrete regions of the brain were studied with histochemical localization and photodensitometric quantification of the metabolic enzyme, hexokinase. Two weeks after a single injection of streptozotocin (65 mg/kg, i.p.), plasma glucose and osmo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91593-6
更新日期：1990-07-02 00:00:00
abstract：:Music is an intriguing stimulus widely used in movies to increase the emotional experience. However, no brain imaging study has to date examined this enhancement effect using emotional pictures (the modality mostly used in emotion research) and musical excerpts. Therefore, we designed this functional magnetic resonanc...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.065
更新日期：2006-02-23 00:00:00
abstract：:Tourette syndrome (TS) is a childhood-onset tic disorder associated with abnormal development of brain networks involved in the sensory and motor processing. An involvement of immune mechanisms in its pathophysiology has been proposed. Animal models based on active immunization with bacterial or viral mimics, direct i...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2014.04.027
更新日期：2015-08-18 00:00:00
abstract：:In vivo microdialysis techniques were used to examine the effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult, ovariectomized rats. Estrogen treatment resulted in a significant increase in the percent change in acetylcholine release induced by potassium re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(96)01375-3
更新日期：1997-02-21 00:00:00
abstract：:The ability to recognize previous experience depends on two neurocognitive processes, familiarity, fast-acting and relatively automatic, and recollection, slower-acting and more effortful. Familiarity appears to mature relatively early in development and is maintained with aging, whereas recollection shows protracted ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.11.016
更新日期：2010-01-15 00:00:00
