Abstract：
:In this study we present data supporting a heterogeneous distribution of the brain-specific S-100 protein on nerve cell plasma membranes from isolated neurons. This has been shown in a previous study by immunoelectron microscopy using peroxidase-conjugated anti-S-100 antiserum and in this study by immunofluorescence using fluorescein-conjugated anti-S-100 antiserum, the specificity of which is discussed. Incubation of the cells at +23 degrees C or at +4 degrees C did not change the distribution pattern of S-100 over the cell membranes, nor did incubation in antimetabolites, or incubation with univalent Fab fragments. We conclude that the membrane-bound S-100 protein with its heterogeneous and polar distribution on the nerve cells is a sign of a protein differentiation of the neuron.
journal_name
Brain Resjournal_title
Brain researchauthors
Hydén H,Rönnbäck Ldoi
10.1016/0006-8993(75)90161-4subject
Has Abstractpub_date
1975-12-26 00:00:00pages
615-28issue
3eissn
0006-8993issn
1872-6240pii
0006-8993(75)90161-4journal_volume
100pub_type
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