Abstract:
:Veratridine-induced depolarization caused a large increase in Ca uptake in the rat hippocampal slice (30.2 vs. 9.0 nM/mg dry weight). This uptake was reduced to 18.4 nM/mg when veratridine was combined with anoxia. When compared with veratridine exposure alone, the combination of anoxia and veratridine increased intracellular Na (460 vs. 380 microM/g), decreased intracellular K (30 vs. 40 microM/g) and decreased ATP levels (0.1 vs. 0.8 nM/mg). The changes in Na, K, and ATP should enhance net Ca uptake, yet Ca uptake was reduced. This suggests an effect of anoxia to block Ca channels. In summary anoxia attenuates depolarization-induced Ca uptake. This may represent a mechanism by which neurons are partially protected against anoxic damage which could be more severe if depolarization-induced Ca uptake was not limited.
journal_name
Brain Resjournal_title
Brain researchauthors
Kass IS,Abramowicz AE,Cottrell JE,Amorim P,Chambers Gdoi
10.1016/0006-8993(94)91547-4subject
Has Abstractpub_date
1994-01-07 00:00:00pages
262-6issue
1-2eissn
0006-8993issn
1872-6240pii
0006-8993(94)91547-4journal_volume
633pub_type
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