Abstract:
:Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modulate glutamatergic synapses at level of postsynaptic density (PSD). Through Western blot, we found that exercise during 1 month increased glutamatergic-related protein content in PSD from cortex of mice. Exercise increased the immunocontent of GluR1 (129%), SAP-97 (179%), GRIP-1 (129%), and in less extent, GluR2/3 (118%) and PSD-95 (112%) proteins. The overall content of NMDA subunits R1, R2A and R2B were not altered in mice that had exercised, however, the phosphorylated NMDA subunits, phospho-NMDAR1 (150%), and phospho-NMDAR2B (183%) showed a strong increase. Because exercise increased the content of phosphorylated forms of NMDA receptors, we evaluated the binding of MK-801, a specific ligand that binds to open NMDA channel. Exercise increased the binding of MK-801 in cortical cellular membranes in 51%. Altogether, our results point to a modulation of glutamatergic synapses by exercise with likely implications in the exercise-induced mental health.
journal_name
Brain Resjournal_title
Brain researchauthors
Dietrich MO,Mantese CE,Porciuncula LO,Ghisleni G,Vinade L,Souza DO,Portela LVdoi
10.1016/j.brainres.2005.09.038subject
Has Abstractpub_date
2005-12-14 00:00:00pages
20-5issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(05)01364-8journal_volume
1065pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract::In light of the evidence that calcium plays a critical role in excitotoxic neuronal death, it has been speculated that the metabotropic glutamate receptor may also contribute to excitotoxic damage through the mobilization of Ca2+ from intracellular stores. In the present study we examined this possibility by studying ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91613-6
更新日期:1991-10-11 00:00:00
abstract::Data from several laboratories indicate that cerebral endothelial cells possess cell surface receptors for numerous vasoactive agents including angiotensin II (AII) and atrial natriuretic factor (ANF). The intracellular messengers of these receptors as well as possible receptor interactions were explored. ANF increase...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)91191-3
更新日期:1991-10-18 00:00:00
abstract::In order to elucidate the functional role of nicotinic receptors in the hypothalamus, the drug-induced release of noradrenaline from hypothalamic synaptosomes was studied utilizing [3H]noradrenaline ([3H]NA). The release of [3H]NA from synaptosomes was significantly increased with an increase of the dose of nicotine, ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(80)91194-4
更新日期:1980-01-27 00:00:00
abstract::Our study aimed to explore the influence of two different stressors: acute (once for 15 min) and chronic (15 min daily for 21 days) exposure to high light open field (HL-OF) or forced swim (FS) on the density of nerve growth factor (NGF) and tyrosine kinase A (TrkA) immunoreactive neurons in the hippocampal CA1 and CA...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2011.01.112
更新日期:2011-04-12 00:00:00
abstract::The time course of autoradiographic binding of major second messengers in the rat brain was studied at 2, 7, and 24 h after withdrawal from butorphanol infusion. [3H]Forskolin and [3H]phorbol 12,13-dibutyrate (PDBu) were used to label adenylate cyclase and protein kinase C (PKC), respectively. Rats were rendered depen...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01127-0
更新日期:1999-03-13 00:00:00
abstract::In anaesthetized cats, effects of iontophoretic application of angiotensin II were studied in the nuclei of the tractus solitarius. Specifically, its effects were tested on single respiratory neurones, having rhythmic activity related temporally with the phrenic nerve discharge, and on presumed reflex interneurones, w...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(87)91232-7
更新日期:1987-03-24 00:00:00
abstract::The roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitization of chronic visceral pain were investigated. A rat model with irritable bowel syndrome (IBS) was established by colorectal distention (CRD) on post-natal days 8-14. Responses of the external oblique muscle of the abdomen to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2013.10.008
更新日期:2014-01-13 00:00:00
abstract::Bilateral quisqualic acid-induced lesions of the nucleus basalis magnocellularis (nbm) in rats disrupted the expression of latent inhibition, a phenomenon thought to be dependent upon selective attention processes. Since grafts of adrenal chromaffin cells to the cerebral cortex of nbm-lesioned rats have been shown to ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(94)01364-n
更新日期:1995-02-13 00:00:00
abstract::We hypothesized that abnormal activity and adrenergic sensitivity in injured dorsal root ganglion (DRG) neurons are due to an intrinsic alteration of the cell body membrane. We investigated the effects of adrenergic stimulus on the activities of Ca2+ and K+ channels of DRG neurons in a rat chronic constriction injury ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01499-7
更新日期:1999-06-19 00:00:00
abstract::The precursor of the non-Abeta-component of Alzheimer's disease (AD) amyloid (NACP, alpha-synuclein) aggregates into insoluble filaments of Lewy bodies (LBs) in Parkinson's disease (PD) and dementia with LBs (DLB). The microtubule-associated protein tau is an integral component of filaments of neurofibrillary tangles ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)01848-x
更新日期:1999-10-02 00:00:00
abstract::Visual-spatial working memory tasks can be decomposed into encoding and retrieval phases. It was hypothesized that encoding of visual-spatial information is cognitively more challenging than retrieval. This was tested by combining electroencephalography with a virtual reality paradigm to observe the modulation in EEG ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2010.05.086
更新日期:2010-08-06 00:00:00
abstract::Following injections of WGA-HRP into lower cervical segments, the distribution of anterograde labeled terminals of spinocerebellar fibers was examined in the vermal cortex of the cat. The labeled terminals were seen in sublobules Ib to VIc, VIIb, VIIIa and VIIIb, and lobule IX. They were present mainly in the medial p...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(85)91261-2
更新日期:1985-12-23 00:00:00
abstract::Near-total dopamine-depleting brain lesions produced in 3-day-old rats by intracerebroventricular injection of the neurotoxin 6-hydroxydopamine led to pronounced increases in striatal serotonin (5-HT) and 5-hydroxyindoleacetic acid contents 1-8 months later. This effect was associated with an increase in in vitro high...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(84)90665-6
更新日期:1984-01-16 00:00:00
abstract::The effect of thyrotropin releasing hormone (TRH) administered either subcutaneously (s.c.) or intracerebroventricularly (i.c.v.) on the analgesic and hypothermic actions of U-50,488H, a highly selective kappa-opiate agonist, was determined in male Swiss Webster mice. Intraperitoneal administration of U-50,488H (8-32 ...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)90144-c
更新日期:1993-10-15 00:00:00
abstract::Fast cyclic voltammetry (FCV) at carbon fibre microelectrodes was used to monitor stimulated noradrenaline (NA) efflux in slices of the ventral part of the rat bed nucleus of stria terminalis (BSTV) superfused with artificial cerebrospinal fluid at 32 degrees C. NA efflux was evoked by local electrical stimulation (tr...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(93)91498-h
更新日期:1993-04-02 00:00:00
abstract::We determined that extracellular potassium ion concentration, [K+]o-induced depolarization, enhances 1-methyl-4-phenylpyridinium ion (MPP+)-induced hydroxyl radical (*OH) generation in the rat striatum. Rats were anesthetized, and sodium salicylate in Ringer's solution (0.5 nmol/microl/min) was infused through a micro...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(99)02238-6
更新日期:2000-01-10 00:00:00
abstract::Light microscopic double labeling immunocytochemistry for vasoactive intestinal peptide (VIP) and gonadotrophin-releasing hormone (GnRH) was carried out on the hypothalami of male and female rats. It was found that the number of VIP boutons that terminate on GnRH neurons and the percentage of GnRH neurons contacted by...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00208-x
更新日期:1998-06-08 00:00:00
abstract::The rubrointerposital projection was studied in cats where wheat germ agglutinin-horseradish peroxidase (WGA-HRP) was implanted in various parts of the interposed nuclei. No retrogradely labelled rubral cells were observed following implantations in the posterior interposed nucleus, and only very few such cells were i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(86)91370-3
更新日期:1986-11-05 00:00:00
abstract::The electrophysiological effects of the non-competitive N-methyl-D-aspartate (NMDA) antagonist (+)-MK-801 (MK-801) on nigrostriatal and mesoaccumbal dopaminergic (DA) neurons were evaluated in chloral hydrate-anesthetized rats. MK-801 (0.05-3.2 mg/kg, i.v.) stimulated the firing rates of 14 (74%) of 19 nigrostriatal D...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91091-r
更新日期:1992-09-11 00:00:00
abstract::Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat sho...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(98)00072-9
更新日期:1998-04-20 00:00:00
abstract::The distribution of calcitonin gene-related peptide (CGRP) and its binding sites in the bulbocavernosus, a striated muscle, are reported. We used immunohistochemistry and [125I]CGRP autoradiography. The pattern of [125I]CGRP binding was restricted to a discrete band that coincides with the distribution of end-plates i...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(89)91064-0
更新日期:1989-09-04 00:00:00
abstract::The sexual and associated behaviour of 10 adult male marmosets was recorded during pair tests with ovariectomized females, before and after bilateral thermal lesions of the hypothalamus. Four sham-lesioned males served as controls. Lesions varied in volume from 1.49 to 3.28 mm3 and extended from the ventromedial hypot...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(88)90405-2
更新日期:1988-11-01 00:00:00
abstract::The present study demonstrates changes in rat brain glial metabolism during the acute phase of epilepsy. Status epilepticus (SE) was induced using the lithium-pilocarpine model. Glial metabolism was measured with (14)C-acetate. Local cerebral blood flow and glucose metabolism were also measured using (14)C-N-isopropyl...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2009.10.074
更新日期:2010-01-22 00:00:00
abstract::We monitored the protein expression profiles of collapsin response mediator protein 2 and 4 (CRMP2 and CRMP4) throughout cat primary visual area 17 at different postnatal ages. Single immunocytochemical stainings revealed a clear effect of cortical maturation on the spatial and laminar distribution profile of CRMP2 an...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2006.03.028
更新日期:2006-05-09 00:00:00
abstract::Starvation inhibits egg-laying in the snail, Lymnaea stagnalis. In starved animals the neurosecretory Caudo-Dorsal Cells (CDC), which produce the egg-laying hormone, are hyperpolarized as compared to the CDC of controls. However, they are more responsive to repetitive intracellular stimulation, which induces the hormo...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(82)90528-5
更新日期:1982-05-13 00:00:00
abstract::Environmental stressors can substantially affect the adaptive response of rats to novelty in a sexually dimorphic manner. Gender-related differences are also observed in neurochemical and behavioural patterns of adult rats following prenatal exposure to diazepam (DZ). In the present study the behavioural reactivity to...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/s0006-8993(01)02462-3
更新日期:2001-06-22 00:00:00
abstract::Although much is known regarding the modulation of ion channels through protein phosphorylation, little is known about their dephosphorylation by protein phosphatases (PrPs). To address this issue we examined the effects of a phosphatase inhibitor, okadaic acid (OA), and protein phosphatases obtained from rabbit skele...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(91)90611-x
更新日期:1991-05-17 00:00:00
abstract::Insular cortex (INS) plays a critical role in pain processing and shows sex differences in functional activation during noxious visceral stimulation. Less is known regarding functional interactions within the INS and between this structure and other parts of the brain. Cerebral blood flow mapping was performed using [...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/j.brainres.2019.04.005
更新日期:2019-08-15 00:00:00
abstract::The distribution of bFGF in mouse and rat retinas was established using an antibody generated against a rat specific bFGF sequence. The patterns established with this antibody were distinctly different in comparison to the immunostaining patterns using antibodies prepared against similar regions of bovine and human bF...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(92)91236-8
更新日期:1992-07-10 00:00:00
abstract::The hippocampal granule cells receive major inputs via the perforant path from other limbic structures such as the amygdala (AM). In this study, we examined Sprague-Dawley (SD) and Wistar rats, the effect of bilateral destructions of the hippocampal granule cells on the process of AM kindling and kindled AM seizures a...
journal_title:Brain research
pub_type: 杂志文章
doi:10.1016/0006-8993(95)00574-a
更新日期:1995-09-11 00:00:00