Abstract：
:Although there are several reports on the alteration of intracellular signal transduction during heat shock in somatic cells, the long term effects of heat shock on neuronal cells remain unknown. In this report, we investigated cyclic AMP (cAMP) accumulation and the expression of heat shock proteins following heat shock in mouse neuroblastoma N18TG2 cells. Basal cAMP accumulation, or that stimulated by serotonin (10 microM), cholera toxin (1 microg/ml), and forskolin (1 microM) was suppressed at 0, 3, and 6 h following heat shock (45 degrees C for 30 min). The cAMP levels were restored at 15 and 24 h after heat shock, corresponding with the expression of stress-induced heat shock protein 72 (HSP72). Quercetin, an inhibitor of HSP expression, decreased the expression of HSP72 and inhibited the recovery of cAMP levels 24 h after heat shock. Quercetin also decreased the basal expression of the constitutive heat shock cognate protein 70 (HSC70) and suppressed cAMP accumulation in non-heat shocked cells. These results suggest that stress-induced HSP72 restores cAMP accumulation to control levels following heat shock and that constitutive HSC70 is related to cAMP levels in non-stress conditions.
journal_name
Brain Resjournal_title
Brain researchauthors
Zensho H,Nishida A,Shimizu M,Uchitomi Y,Yamawaki Sdoi
10.1016/s0006-8993(98)00072-9subject
Has Abstractpub_date
1998-04-20 00:00:00pages
278-83issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(98)00072-9journal_volume
790pub_type
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