Site of interaction of serotonin and desglycinamide-arginine-vasopressin in maintenance of ethanol tolerance.

abstract：:Experiments were done in cats to identify neurons in the paramedian reticular nucleus (PRN) sending collateral axons to the region of the intermediolateral nucleus (IML) at different levels of the thoracic cord by using lectin-conjugated horseradish peroxidase (HRP) and double-labeling fluorochrome histochemistry to r...

journal_title：Brain research

authors： Elisevich K,Caverson MM,Flumerfelt BA,Hrycyshyn AW,Ciriello J

更新日期：1987-04-07 00:00:00

abstract：:Intracerebroventricular (ICV) streptozotocin (STZ) treated rat has been described as a suitable model for sporadic Alzheimer's disease (AD). Central application of STZ has demonstrated behavioral and neurochemical features that resembled those found in human AD. Chronic treatments with antioxidants, acetylcholinestera...

journal_title：Brain research

authors： Ponce-Lopez T,Liy-Salmeron G,Hong E,Meneses A

更新日期：2011-12-02 00:00:00

abstract：:After transplantation of autologous sciatic nerve segments into the retina of adult hamsters for 1-2 months, retrograde labelling with horseradish peroxidase demonstrated a population of ganglion cells situated peripheral to the graft. If an additional lesion was placed between the insertion of the graft and the optic...

journal_title：Brain research

authors： So KF,Xiao YM,Diao YC

更新日期：1986-07-02 00:00:00

abstract：:The effect of serotonin agonists on the rhythmic excretion of the melatonin metabolite 6-sulphatoxymelatonin was examined in rats. The animals were maintained in 12L:12D and administered saline, quipazine (10 mg/kg), (+/-)-2-propylamino-8-hydroxy-1,2,3,4-tetrahydronaphthalene hydrobromide (8-OH-DPAT, 5 mg/kg) or buspi...

journal_title：Brain research

authors： Kennaway DJ,Rowe SA,Ferguson SA

更新日期：1996-10-21 00:00:00

abstract：:We compared the effect of mecamylamine and fluoxetine on the hippocampal noradrenaline (NA) release evoked by nicotine in vitro. Nicotine (100 microM) increased the basal release of [3H]NA from rat hippocampal slices. This effect was blocked by the potent nicotinic antagonist mecamylamine in a dose-dependent manner (I...

journal_title：Brain research

authors： Hennings EC,Kiss JP,Vizi ES

更新日期：1997-06-13 00:00:00

abstract：:We used rabbit antisera against manganese (Mn)-superoxide dismutase for immunohistochemical studies of localization in the rat neostriatum. Immunostaining was intense in large-sized neurons and several medium-sized neurons, but it was moderate to weak in other cells. Double immunostaining with monoclonal antibody to c...

journal_title：Brain research

authors： Inagaki S,Suzuki K,Taniguchi N,Takagi H

更新日期：1991-05-17 00:00:00

abstract：:We recently reported raphe neurones which frequently fired spikes in short bursts. However, the action potentials were broad and the neurones fired in a slow and regular pattern, suggesting they were an unusual type of 5-hydroxytryptamine (5-HT) neurone. In the present study, we investigated whether these putative bur...

journal_title：Brain research

authors： Hajós M,Sharp T

更新日期：1996-11-18 00:00:00

abstract：:The formation of reactive oxygen species (ROS) has been suggested to be associated with excitotoxicity but the involvement of cytoplasmic enzymes in ROS formation is not clearly known. In the present study, we examined the role of xanthine oxidase (XO), nitric oxide synthase (NOS) and phospholipase A(2) (PLA(2)) in gl...

journal_title：Brain research

authors： Sanganahalli BG,Joshi PG,Joshi NB

更新日期：2005-03-10 00:00:00

abstract：:Enkephalin immunoreactive neurons within the nucleus tractus solitarius (NTS) were found to project to the parabrachial nucleus of the cat with the use of a combination of immunohistochemistry and retrograde transport of horseradish peroxidase. Double labelled neurons were located in the medial, parvocellular and comm...

journal_title：Brain research

authors： Maley BE,Panneton WM

更新日期：1988-03-01 00:00:00

abstract：:We previously reported that PC12h cells are killed by a high oxygen atmosphere. In this study, we further characterized this oxygen-induced cell death and found apoptotic features, as follows. Firstly, chromatin condensation was observed in cells cultured in a 50% O2 atmosphere. Secondly, cycloheximide and cordycepin,...

journal_title：Brain research

authors： Kubo T,Enokido Y,Yamada M,Oka T,Uchiyama Y,Hatanaka H

更新日期：1996-09-16 00:00:00

abstract：:We have previously shown that NS-7 [4-(4-fluorophenyl)-2-methyl-6-(5-piperidinopentyloxy)pyrimidine hydrochloride] reduces the size of cerebral infarction measured by 2,3,5-triphenyltetrazolium chloride staining at 48 h after permanent middle cerebral artery occlusion (MCAO) in rats. To determine whether NS-7 improves...

journal_title：Brain research

authors： Tamura M,Aoki Y,Seto T,Itoh Y,Ukai Y

更新日期：2001-01-26 00:00:00

abstract：:Ferulic acid (FA) has an important effect on scavenging free radicals, which is related to the alleviation of various neurodegenerative diseases. However, there are few studies about its effects on vascular dementia. In this study, we demonstrated the effect of FA on oxidative damage of brain microvascular endothelial...

journal_title：Brain research

authors： Chen JL,Duan WJ,Luo S,Li S,Ma XH,Hou BN,Cheng SY,Fang SH,Wang Q,Huang SQ,Chen YB

更新日期：2017-07-01 00:00:00

abstract：:The endocannabinoid system is a promising therapeutic target in a wide variety of diseases. However, the non-desirable psychotropic effects of natural and synthetic cannabinoids have largely counteracted their clinical usefulness. These effects are mostly mediated by cannabinoid receptors of the CB(1) type, that exhib...

journal_title：Brain research

authors： Tolón RM,Núñez E,Pazos MR,Benito C,Castillo AI,Martínez-Orgado JA,Romero J

更新日期：2009-08-04 00:00:00

abstract：:Recent reports have suggested that the excitatory amino acid L-glutamate is a neurotransmitter released by baroreceptor afferent nerves at their termination in the nucleus tractus solitarii (NTS). In this study we have examined the effect on arterial pressure, heart rate and baroreflex activity of the glutamate antago...

journal_title：Brain research

authors： Talman WT,Perrone MH,Scher P,Kwo S,Reis DJ

更新日期：1981-07-27 00:00:00

abstract：:Drug addiction is characterized by persistent relapse vulnerability during abstinence. In abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts that were previously associated with drug use. This clinical scenario is modeled in preclinical studies using the context-induced reinst...

journal_title：Brain research

authors： Marchant NJ,Kaganovsky K,Shaham Y,Bossert JM

更新日期：2015-12-02 00:00:00

abstract：:After spinal cord injury (SCI), the rapidly upregulated chondroitin sulfate proteoglycans (CSPGs), the prominent chemical constituents and main repulsive factors of the glial scar, play an important role in the extremely limited ability to regenerate in adult mammals. Although many methods to overcome the inhibition h...

journal_title：Brain research

authors： Zhou HX,Li XY,Li FY,Liu C,Liang ZP,Liu S,Zhang B,Wang TY,Chu TC,Lu L,Ning GZ,Kong XH,Feng SQ

更新日期：2014-10-24 00:00:00

abstract：:Rats were subjected to transient global ischemia (four vessel occlusion) and time-related changes in the selectively vulnerable hippocampal field CA1 were characterized. The assessment included ex vivo field responses to afferent stimulation, silver staining, calpain-induced spectrin breakdown, chromatolysis, and cell...

journal_title：Brain research

authors： Bartus RT,Dean RL,Mennerick S,Eveleth D,Lynch G

更新日期：1998-04-20 00:00:00

abstract：:In rats under urethane, iontophoretic applications of GABA (30-60 nA) in the str. pyramidale of CA1, showed a rapidly fading inhibitory effect. By contrast, GABA had a well-maintained inhibitory effect in str. radiatum. During iontophoresis of nipecotic acid (30-85 nA) identical applications of GABA in str. pyramidale...

journal_title：Brain research

authors： Dalkara T

更新日期：1986-02-26 00:00:00

abstract：:Tetramethylpyrazine (TMP) is one of the alkaloids contained in Ligustrazine which has been used in traditional Chinese medicine as an analgesic for injury and dysmenorrhea. ATP can elicit the sensation of pain. This study observed the effects of TMP on ATP-activated current (IATP) in rat DRG neurons. TMP (0.1-1 mM) co...

journal_title：Brain research

authors： Liang SD,Xu CS,Zhou T,Liu HQ,Gao Y,Li GL

更新日期：2005-04-08 00:00:00

abstract：:The effect of (S)alpha-fluoromethylhistidine (FMH), a specific inhibitor of histamine synthesis from histidine, on ischemic damage was examined in gerbil brain after forebrain ischemia. Two h after subcutaneous FMH injection, the histamine content of the brain was significantly reduced. Neuronal loss in the CA2 region...

journal_title：Brain research

authors： Sugimoto K,Abe K,Lee TH,Sakurai E,Yanai K,Kogure K,Itoyama Y,Watanabe T

更新日期：1994-12-15 00:00:00

abstract：:Ghrelin can alleviate cancer chemotherapy-induced dyspepsia in rodents, though the neural mechanisms involved are not known. Therefore, ghrelin projections from the lateral hypothalamus (LH) and its involvement in the regulation of gastric motility in cisplatin-treated rats were investigated with a multi-disciplined a...

journal_title：Brain research

authors： Gong Y,Liu Y,Liu F,Wang S,Jin H,Guo F,Xu L

更新日期：2017-03-15 00:00:00

abstract：:Reducing external calcium from 1.0 to 0.1 mM increased the flash sensitivity and the time-to-peak (tp) of linear responses of rod photoreceptors. The quantitative relation between flash sensitivity and tp was the same as during light adaptation. However, the calcium ionophore A23187 reduced sensitivity without affecti...

journal_title：Brain research

authors： Matthews GG

更新日期：1985-04-15 00:00:00

abstract：:Two experiments were undertaken to investigate dopaminergic involvement in the local rate of responding on a fixed ratio 5 (FR5) instrumental lever pressing schedule. Rats were trained to press a lever for food reinforcement on a FR5 schedule, and a computer program was used to record the interresponse time (IRT) for ...

journal_title：Brain research

authors： Salamone JD,Kurth PA,McCullough LD,Sokolowski JD,Cousins MS

更新日期：1993-11-19 00:00:00

abstract：:In humans and many other mammalian species, the behavioural consequences of a cortical lesion tend to be milder when it occurs early in life, and there is evidence that an important factor contributing to the behavioural sparing in the young is the formation of new thalamo-cortical connections by thalamic neurons init...

journal_title：Brain research

authors： Gautschi M,Clarke PG

更新日期：2007-09-05 00:00:00

abstract：:In order to elucidate the roles of hippocampal nitric oxide (NO) synthesis in working and reference memory performance of rats, the effects of intrahippocampal injections of the NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), on this behavior were examined with a three-panel runway task. In the worki...

journal_title：Brain research

authors： Ohno M,Yamamoto T,Watanabe S

更新日期：1993-12-31 00:00:00

abstract：:Synaptophysin and synapsin, closely correlated on synaptic vesicles in terminals, may show a differential distribution at synapse formation and maturation. In order to disclose the fine structural details of these differences, synapsin and synaptophysin distribution was studied by immunocytochemistry on ligated bovine...

journal_title：Brain research

authors： Quatacker J,Partoens P,De Potter W

更新日期：1998-08-17 00:00:00

abstract：:Unlike the basal ganglia input from the midline and intralaminar nuclei, the origin and prominence of striatal projections arising in the lateral thalamus varies considerably among mammals being most restricted in the opossum and monkey, most extensive in the rat. To get further insight into the evolution of thalamo-s...

journal_title：Brain research

authors： Künzle H

更新日期：2006-07-19 00:00:00

abstract：:The hyperphagic properties of insulin (10 U/kg, s.c.) were transiently (2h) and dose-dependently inhibited (30%) by central pretreatment with naltrexone (20-50 micrograms, i.c.v.). The irreversible mu opioid antagonist, beta-funaltrexamine (B-FNA, 20 micrograms, i.c.v.) significantly inhibited insulin hyperphagia by 2...

journal_title：Brain research

authors： Beczkowska IW,Bodnar RJ

更新日期：1991-05-03 00:00:00

abstract：:The characteristics of dopamine adenylate cyclase in the rat striatum were first studied on homogenates of fresh tissues. In the assay conditions used, dopamine (10(-4) M) stimulated the enzyme activity by 250%. This effect was completely blocked by fluphenazine (10(-5) M; Ki=9X10(-9) M) and by phentolamine (10(-5) M;...

journal_title：Brain research

authors： Bockaert J,Premont J,Glowinski J,Thierry AM,Tassin JP

更新日期：1976-05-07 00:00:00

abstract：:Local formation of oestrogens from androgens by aromatase cytochrome P-450 within brain cells is crucial for the sexual differentiation of the mammalian CNS. Aromatase activity has been detected in several brain regions of the developing rodent brain. In the present study, we used a mouse-specific, peptide-generated, ...

journal_title：Brain research

authors： Beyer C,Green SJ,Barker PJ,Huskisson NS,Hutchison JB

更新日期：1994-02-28 00:00:00