Abstract：
:We compared the effect of mecamylamine and fluoxetine on the hippocampal noradrenaline (NA) release evoked by nicotine in vitro. Nicotine (100 microM) increased the basal release of [3H]NA from rat hippocampal slices. This effect was blocked by the potent nicotinic antagonist mecamylamine in a dose-dependent manner (IC50 = 0.19 microM). The selective serotonin reuptake inhibitor (SSRI) fluoxetine also antagonised the response to nicotine in a dose-dependent manner with a similar strength (IC50 = 0.57 microM). Our data indicate that fluoxetine has nicotinic acetylcholine receptor antagonist effect in the central nervous system. The possible clinical significance of this finding is discussed.
journal_name
Brain Resjournal_title
Brain researchauthors
Hennings EC,Kiss JP,Vizi ESdoi
10.1016/s0006-8993(97)00343-0subject
Has Abstractpub_date
1997-06-13 00:00:00pages
292-4issue
2eissn
0006-8993issn
1872-6240pii
S0006-8993(97)00343-0journal_volume
759pub_type
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