Abstract：
:Vestibular nerve branches innervating the sensory epithelia of the three semicircular canals or of the three otolith organs of frogs were selectively labeled in-vitro with biocytin. Labeled afferent fibers from the semicircular canals, utricle, and lagena were encountered in each of the four vestibular nuclei and their projections overlapped considerably. Saccular afferent fibers projected to the dorsal (acoustic) nuclei and smaller projections to the vestibular nuclei were regionally restricted. Per semicircular canal or otolith organ about equal numbers (11-14) of medium sized vestibular neurons (between 7.5 and 17 microm in diameter) were dye-coupled to afferent fibers. Most of these dye-coupled vestibular neurons were located in the lateral and descending vestibular nuclei between the VIIIth and IXth nerves. The superior vestibular nucleus was relatively free of dye-coupled vestibular neurons. The location of this subpopulation of central vestibular neurons supports the notion that these neurons are part of a particular vestibulospinal pathway. In addition, from each of the canal and/or otolith organs about 3-4 efferent vestibular neurons were labeled retrogradely. These neurons (between 15 and 26 microm in diameter) were located ventral to the vestibular nuclear complex. The branching of efferent vestibular neurons was shown by the presence of neurons that were double labeled by two different fluorescent dyes applied in the same experiment to the anterior and posterior ramus of the same VIIIth nerve, respectively. The branching of these efferent neuron axons explained the presence of collaterals and terminals in the sensory epithelia of a number of untreated ipsilateral endorgans.
journal_name
Brain Resjournal_title
Brain researchauthors
Birinyi A,Straka H,Matesz C,Dieringer Ndoi
10.1016/s0006-8993(01)03075-xsubject
Has Abstractpub_date
2001-12-07 00:00:00pages
44-59issue
1-2eissn
0006-8993issn
1872-6240pii
S0006-8993(01)03075-Xjournal_volume
921pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:Perinatal exposure to environmental tobacco smoke (ETS) has adverse effects on neurobehavioral development. In the current study, rats were exposed to ETS during gestation, during the early neonatal period, or both. Brains and hearts were examined for alterations in adenylyl cyclase (AC) activity and for changes in be...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02145-x
更新日期：2001-04-13 00:00:00
abstract：:The early, prenatal formation of noradrenergic projections to the forebrain has led to the proposition that these axons exert a trophic influence on cerebral cortex during ontogeny. To test this hypothesis, we have examined a number of different structural features of cortical development following prenatal lesions of...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(82)90077-3
更新日期：1982-01-01 00:00:00
abstract：:The physiological role of amyloid precursor protein (APP), whose anomalous metabolite is a putative pathogen for Alzheimer disease, remains unclear. From the enhanced responsiveness to glutamate in cultured hippocampal neurons after the introduction of cDNA of APP695 (an isoform of APP dominant in human brain) using a...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(01)02983-3
更新日期：2001-11-09 00:00:00
abstract：:Responses elicited by stimulating the pre-versus postganglionic nerves were compared in cat bladder parasympathetic neurons. We observed that synaptic potentials recorded on stimulating the postganglionic nerve trunk were different from those elicited with preganglionic nerve stimulation. These findings suggest that l...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)91634-9
更新日期：1987-12-01 00:00:00
abstract：:To evaluate a hypothesized role of the vagus in the circannual metabolic cycle of hibernators, measures of annual weight gain, weight loss and cycle period were taken for the ground squirrel, Citellus lateralis, maintained in constant environmental conditions before and after subdiaphragmatic vagotomy. The surgery did...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90996-0
更新日期：1986-01-29 00:00:00
abstract：:The lateral geniculate nucleus (LGN) of a fetal rat was transplanted to the visual cortex (VC) of a neonatal rat. A current source-density analysis of field potentials and an intracellular study of neuronal responses were conducted in slice preparations by electrical stimulation of transplanted LGN and host VC. The re...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90554-3
更新日期：1987-09-29 00:00:00
abstract：:Changes in GABA(A) receptor alpha(1) subunit gene expression occur in the globus pallidus and substantia nigra pars reticulata following lesions of the nigrostriatal tract. To determine whether these changes are translated at the protein level, we performed quantitative autoradiography with the alpha(1) selective liga...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)02081-3
更新日期：2000-04-17 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) promotes survival of injured dopaminergic nigrostriatal neurons of the adult rodent substantia nigra pars compacta, as well their development in vitro. BDNF deficiency may play a role in Parkinson's disease, as the surviving dopaminergic nigrostriatal neurons have reduced level...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.01.052
更新日期：2005-03-28 00:00:00
abstract：:Insulin has emerged as an important neuropeptide. Central actions of insulin appear to oppose those in the periphery. Insulin is transported across the blood-brain barrier (BBB) by a saturable transport system. The permeability of the BBB to insulin is altered by various events, but no studies exist that have examined...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(00)03247-9
更新日期：2001-03-30 00:00:00
abstract：:With the increasing worldwide incidence of Alzheimer's disease (AD), there is a critical need for the discovery of more effective diagnostic methods. However, development of diagnostic tools in AD has been hindered by obstacles such as the absence of exact biomarkers. Apoptosis caused by amyloid-β (Aβ) plays an import...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2016.06.041
更新日期：2016-09-01 00:00:00
abstract：:As a means of probing the chemotransducer, impulse sequences from in vitro, superfused sinus nerve-carotid body preparations were analyzed for departures from randomness. Twelve of 17 spike trains showed interval histograms that did not differ significantly from exponential. Thus these sequences resembled a Poisson (r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90908-9
更新日期：1984-01-30 00:00:00
abstract：:Previous data suggest a relationship between the loss of response to levodopa in Parkinson's disease (PD) patients with the co-occurrence of dementia, but the role of alterations in the dopamine system has not been explored. We measured the extent of striatal DA loss and changes in striatal DA D(2) and D(3) receptors ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03396-6
更新日期：2002-11-15 00:00:00
abstract：:A large body of evidence indicates that both the altered cytokines that mediate the immune-inflammatory process and abnormal gray matter are associated with schizophrenia. Whether peripheral cytokines are related to cerebral structural abnormality remains unclear. Therefore, we aimed to investigate the association of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2019.146463
更新日期：2019-12-01 00:00:00
abstract：:GABAA receptors (GABAARs) and glycine receptors (GlyRs) are two principal inhibitory chloride ion channels in the central nervous system. The two receptors do not function independently but cross-talk to each other, i.e., the activation of one receptor would inhibit the other. This cross-talk is present in different p...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2020.147071
更新日期：2020-12-01 00:00:00
abstract：:K+ and Cl- transport using 42K+ and 36Cl- was studied in primary astrocyte cultures prepared from neonatal rat brains. A component of 42K+ uptake was sensitive to both furosemide and bumetanide with maximum inhibition being obtained at 1 and 0.01 mM concentrations of the inhibitors, respectively. Furosemide and bumeta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(85)91282-x
更新日期：1985-12-30 00:00:00
abstract：:This study determined baroreceptor reflex (BR) function in conscious rats which had received sham or electrolytic lesions of the anteroventral third ventricle (AV3V) 54-56 days previously. Resting mean arterial pressure (MAP) and heart rate (HR) values of the AV3V-lesion rats were similar to those of sham-lesion rats ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01561-9
更新日期：1999-07-24 00:00:00
abstract：:We studied whether the antinociceptive effect produced by intracerebroventricular injection of delta-sleep-inducing peptide (DSIP) to mice involved the monoaminergic pathways that descended from brainstem to spinal cord (the descending inhibitory systems). In the tail-pinch test, the antinociceptive effect of DSIP was...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(89)91569-2
更新日期：1989-02-20 00:00:00
abstract：:The characteristics of [3H]sulpiride binding to the D2 dopamine receptor in rat striatal membranes were examined under several conditions. In the absence of sodium ions, the specific binding of [3H]sulpiride could not be detected. In the direct binding experiment, at 25 degrees C, the affinity of [3H]sulpiride for D2 ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(87)90040-0
更新日期：1987-02-03 00:00:00
abstract：:Prominent cellular responses to axonal interruption include enhanced synthesis of RNA and protein in the neuronal perikaryon, and proliferation of reactive Schwann cells. Since morphine has been shown to significantly depress cellular metabolism, we examined its effect on these and other reparative responses underlyin...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(79)91010-2
更新日期：1979-10-19 00:00:00
abstract：:The effect of intrathecal (i.t.) galanin (GAL) on the prolonged increase of spinal reflex excitability produced by conditioning stimulation (CS) of unmyelinated muscle afferents was studied in decerebrate, spinalized, unanesthetized rats. A CS train (1 Hz, 20 s) applied to the unmyelinated fibers in the gastrocnemius ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)91037-2
更新日期：1991-02-15 00:00:00
abstract：:Estrogen receptor α (ERα) isoforms with complex types of alternative splicing are naturally present in the human brain and may affect canonical receptor signaling. In the present study we investigated transcriptional activity of common ERα splice variants from this group with different molecular defects: MB1 (intron r...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2012.12.050
更新日期：2013-03-15 00:00:00
abstract：:In pentobarbital-anesthetized rats, responses of single neurons in ventrolateral orbital cortex (VLO) to noxious visceral (colorectal distension, CRD) and cutaneous stimulation were recorded. Of 71 neurons identified on the basis of spontaneous activity, 44 responded to CRD. CRD caused inhibition of neuronal activity ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)01200-2
更新日期：1995-01-16 00:00:00
abstract：:Immunohistochemical localization of brain-derived neurotrophic factor (BDNF) in the monkey brain was investigated using a polyclonal anti-BDNF antibody produced in our laboratory. The antibody recognized a single band in monkey brain homogenates, and the estimated molecular weight was approximately 14 kDa, which corre...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(99)01082-3
更新日期：1999-03-13 00:00:00
abstract：:Superfusion of slices of the dorsal zone of the lumbar enlargement with an artificial cerebrospinal fluid was used to investigate the possible modulation by GABA receptor ligands of the in vitro release of calcitonin gene-related peptide- and substance P-like materials (CGRPLM and SPLM) from the rat spinal cord. Where...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(10)80048-4
更新日期：1992-06-26 00:00:00
abstract：:Excessive stimulation of neurons by glutamic acid initiates a destructive cascade of ion fluxes, cellular swelling, and death. Homeostatic mechanisms which rectify these disturbances depend largely upon transmembrane ion gradients maintained by Na+,K(+)-ATPase (NaP). We proposed that the neurotoxicity of glutamate is ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(92)90982-f
更新日期：1992-09-18 00:00:00
abstract：:Primary cultures of astrocytes exhibit a polygonal morphology, but on treatment with agents that increase cAMP they change to stellate cells. We found that astrocyte stellation also occurred on replacing the culture medium with saline buffered with HEPES. However, stellation did not occur when the medium was replaced ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)02819-6
更新日期：2002-08-09 00:00:00
abstract：:Long-term potentiation (LTP) consists of an enhanced response to released transmitter by the quisqualate/AMPA subclass of glutamate receptors with little change in the slower currents generated by the NMDA receptor subclass. Recent computer simulations suggest that a decrease in the resistance of dendritic spines woul...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(91)90454-4
更新日期：1991-01-11 00:00:00
abstract：:Prenatal exposure to opiates, which is invariably followed by postnatal withdrawal, can affect cognitive performance. To further characterize these effects, we examined radial 8-arm maze performance and expression of brain derived neurotrophic factor (BDNF) in male rats prenatally exposed to the opiate l-alpha-acetylm...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2008.01.020
更新日期：2008-03-10 00:00:00
abstract：:Metabotropic glutamate receptors (mGluRs) are thought to mediate diverse processes in brain including synaptic plasticity and excitotoxicity. These receptors are often divided into three groups by their pharmacological profiles. [3H]Glutamate binding in the presence of compounds selective for ionotropic glutamate rece...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00818-4
更新日期：1997-10-31 00:00:00
abstract：:The short and long-term effects of systemic administration of kainic acid to immature animals were studied in rats. Kainic acid was administered systemically to rats of 1-30 days of age. The rats were monitored for both behavioral and EEG changes. To study the effects of kainic acid on seizure susceptibility, status e...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(88)90066-1
更新日期：1988-03-01 00:00:00
