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Association of peripheral cytokine levels with cerebral structural abnormalities in schizophrenia.

Abstract：

:A large body of evidence indicates that both the altered cytokines that mediate the immune-inflammatory process and abnormal gray matter are associated with schizophrenia. Whether peripheral cytokines are related to cerebral structural abnormality remains unclear. Therefore, we aimed to investigate the association of peripheral cytokine levels with gray matter abnormalities at the whole brain level in schizophrenia. Forty-four outpatients with schizophrenia and 44 controls were recruited. The serum levels of interleukin-1 beta (IL-1β), IL-2, IL-6, IL-8, interferon-gamma (IFN-γ), transforming growth factor-beta (TGF-β), and IL-10 were measured using a quantitative chemiluminescence assay. High-resolution T1 weighted images were acquired from all subjects and processed using FreeSurfer software to obtain the cortical thickness, surface area, and cortical and subcortical gray matter volumes. The cytokines and cerebral structures were compared between patients and controls using analysis of covariance (ANCOVA). The association between the cytokines and whole cerebral structures was performed using stepwise linear regression. Patients had higher levels of IL-2, IL-6, IL-8, and IL-10 than controls. In patients, the IL-6 level was significantly associated with the cortical thickness in the left pars opercularis, right pars triangularis, left superior temporal gyrus, and right middle temporal gyrus, which showed structural differences between the two groups. Altered cytokine levels may be associated with particular but not all cortical abnormalities in schizophrenia, especially IL-6, which was significantly associated with the abnormal cortical thickness of the bilateral Broca's area and temporal gyrus, which provided neuroimaging evidence to support the relationship between peripheral cytokines and the cerebral cortex in schizophrenia.

journal_name

Brain Res

journal_title

Brain research

authors

Wu D,Lv P,Li F,Zhang W,Fu G,Dai J,Hu N,Liu J,Xiao Y,Li S,Shah C,Tao B,Zhao Y,Gong Q,Lui S

doi

10.1016/j.brainres.2019.146463

subject

Has Abstract

pub_date

2019-12-01 00:00:00

pages

146463

eissn

0006-8993

issn

1872-6240

pii

S0006-8993(19)30517-7

journal_volume

1724

pub_type

杂志文章

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Association of peripheral cytokine levels with cerebral structural abnormalities in schizophrenia.