Serotonin and dopamine afferents to the rat locus coeruleus: a biochemical study after lesioning of the ventral mesencephalic tegmental-A10 region and the raphé dorsalis.

abstract：:Tyrosine hydroxylase phenotype expression was investigated in the catecholaminergic population of the locus coeruleus neurons of two pure inbred mouse strains, Balb/C and C57Black/6. Therefore, we have characterized the precise organization of tyrosine hydroxylase-expressing perikarya population, in control animals an...

journal_title：Brain research

authors： Ginovart N,Marcel D,Bezin L,Garcia C,Gagne C,Pujol JF,Weissmann D

更新日期：1996-05-20 00:00:00

abstract：:The mRNA level of the 17-kDa protein neurogranin (NG), a postsynaptic substrate of the protein kinase C, has previously been found to be decreased in rat forebrain after 24-h sleep deprivation (SD). To investigate the functional significance of this finding in various forebrain regions, the effect of 24-h SD on the mR...

journal_title：Brain research

authors： Neuner-Jehle M,Rhyner TA,Borbély AA

更新日期：1995-07-10 00:00:00

abstract：:Autoradiographic techniques were used to test if positive modulators of AMPA-type glutamate receptors have regionally differentiated effects on ligand binding. Cyclothiazide, a drug with ten fold greater effects on 'flip' than 'flop' splice variants of the receptors, had unequal effects across the subdivisions of hipp...

journal_title：Brain research

authors： Kessler M,Mutneja MS,Rogers G,Lynch G

更新日期：1998-02-02 00:00:00

abstract：:The globus pallidus plays a critical role in movement regulation. Morphological studies have shown that group I mGluRs including mGluR1 and mGluR5 are expressed in the globus pallidus. Up to now, little is known about the in vivo electrophysiological effects of group I mGluRs on the pallidal neurons. The present study...

journal_title：Brain research

authors： Sun XR,Chen L,Chen WF,Yung WH

更新日期：2012-10-05 00:00:00

abstract：:The action of the epileptogenic agent pentylenetetrazol (PTZ) on a cloned potassium channel of the rat brain was studied. The Kv1.1 channel was expressed in oocytes of Xenopus laevis and potassium currents were investigated in outside-out and inside-out membrane patches. The results show that PTZ increased the multi-c...

journal_title：Brain research

authors： Madeja M,Musshoff U,Lorra C,Pongs O,Speckmann EJ

更新日期：1996-05-25 00:00:00

abstract：:Endogenous hyperprolactinaemia was induced in intact male rats by transplantation of pituitaries under the kidney capsule. Five days later the utilization of noradrenaline (NA) and dopamine (DA) in individual brain nuclei and changes of plasma prolaction (PRL) were measured. Inhibition of catecholamine synthesis by al...

journal_title：Brain research

authors： Kovács GL,Drago F,Acsai L,Tihanyi A,Scapagnini U,Telegdy G

更新日期：1984-12-17 00:00:00

abstract：:The effect of anesthesia upon the functional outcome after experimental spinal cord injury (SCI) was studied in 221 rats subjected to graded weight drop contusion in the thoracic cord. Neurologic function was assessed in a blinded fashion for one week after injury using a modification of the method of Tarlov. The post...

journal_title：Brain research

authors： Salzman SK,Mendez AA,Sabato S,Lee WA,Ingersoll EB,Choi IH,Fonseca AS,Agresta CA,Freeman GM

更新日期：1990-06-25 00:00:00

abstract：:Rats were anesthetized with a continuous infusion of pentobarbital. First we showed that electroacupuncture (EA) suppressed the tail flick nociceptive reflex. Naltrexone (a long acting opiate antagonist) was given either intravenously or intrathecally to attempt to block this EA effect. The naltrexone prevented this E...

journal_title：Brain research

authors： Pomeranz B,Bibic L

更新日期：1988-06-14 00:00:00

abstract：:Suction lesions of the right frontal cerebral cortex in rats induce a period of spontaneous hyperactivity. The hyperactivity, as measured by an increase in running wheel activity begins about one week post-operatively and continues throughout the remainder of a 30-day observation period. The increased activity is acco...

journal_title：Brain research

authors： Pearlson GD,Robinson RG

更新日期：1981-08-10 00:00:00

abstract：:The ability of membrane-associated peptidases from the brains of spontaneously hypertensive rats (SHRs) and normotensive Wistar-Kyoto (WKY) rats to metabolize iodinated angiotensin (125I-Ang II) and 125I-Ang III was compared. 125I-Ang II was metabolized to 125I-Ang III and other fragments exclusively by membrane-assoc...

journal_title：Brain research

authors： Cook VI,Wright JW,Wright SA,Harding JW

更新日期：1990-10-08 00:00:00

abstract：:It has been hypothesized on the basis of animal models of epilepsy that abnormal neural activity in epilepsy may be related to reorganized neural circuits that facilitate epileptogenesis. Little evidence of this was available for human epilepsy. This paper provides the first evidence of such reorganization of a hippoc...

journal_title：Brain research

authors： de Lanerolle NC,Kim JH,Robbins RJ,Spencer DD

更新日期：1989-08-28 00:00:00

abstract：:Using immunohistochemistry and immunoblots, we show that alterations in hippocampal microtubule-associated protein-2 appear to be highly correlated with contextual memory as measured by significantly heightened fear responses. Compared to naive controls, rats trained in a novel context showed significantly increased i...

journal_title：Brain research

authors： Woolf NJ,Zinnerman MD,Johnson GV

更新日期：1999-03-06 00:00:00

abstract：:The cholecystokinin (CCK) concentration in individual brain stem nuclei of rat was determined using the Palkovits punch method19 and the CCK RIA3, CCK has a unique distribution in the brain stem, unlike other neuropeptides and biogenic amines8,19. In general, the CCK levels in the brain stem are 5-20% of rat cerebral ...

journal_title：Brain research

authors： Beinfeld MC,Palkovits M

更新日期：1982-04-22 00:00:00

abstract：:Tetanic stimulation of fibers in the hippocampal slice preparation produces long-term potentiation (LTP) and also decreases the in vitro incorporation of phosphate into the alpha subunit of pyruvate dehydrogenase (alpha PDH). This paper describes 6 experiments that were undertaken to replicate this observation. Hippoc...

journal_title：Brain research

authors： Hoch DB,Dingledine RJ,Wilson JE

更新日期：1984-06-04 00:00:00

abstract：:Intracellular and extracellular recordings from CA3 hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-D-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (D-2-amino-5-phosphonova...

journal_title：Brain research

authors： Neuman R,Cherubini E,Ben-Ari Y

更新日期：1988-09-06 00:00:00

abstract：:The effect of lead as a neurotoxic agent has been associated with alterations in calcium metabolism. On this line, the present study shows that lead alters the characteristics of [3H]nitrendipine ([ 3H]NDP) binding to rat striatal membranes. In vitro, lead shares the action of calcium in enhancing [3H]NDP binding alth...

journal_title：Brain research

authors： Rius RA,Lucchi L,Govoni S,Trabucchi M

更新日期：1984-11-19 00:00:00

abstract：:A decrease in the number of neuronal profiles in the isocortex of man may be observed on microscopic sections in aging and in degenerative diseases such as Alzheimer's disease. It can be the consequence of a loss of neurons per unit volume or of a reduction of the neuronal volume (i.e. pseudo-loss). This latter possib...

journal_title：Brain research

authors： Duyckaerts C,Llamas E,Delaère P,Miele P,Hauw JJ

更新日期：1989-12-11 00:00:00

abstract：:The central amygdaloid nucleus (CeA) receives projection from the parabrachial nucleus (PBN) gustatory neurons and descendingly projects to the PBN, and taste responses in the PBN are significantly affected by stimulation or lesion of the CeA. To examine whether the GABA receptors within the CeA are involved in this m...

journal_title：Brain research

authors： Kang Y,Yan J,Huang T

更新日期：2004-11-26 00:00:00

abstract：:EEG recordings of hippocampal theta activity and neocortical activity were correlated with direct observations and photographic recordings of the behaviour of unrestrained cats. The behaviour studied included (1) both spontaneous and induced changes in level of arousal (sleep-wakefulness), (2) different types of orien...

journal_title：Brain research

authors： Kemp IR,Kaada BR

更新日期：1975-09-23 00:00:00

abstract：:As in many humans suffering from lupus erythematosus, the development of systemic autoimmunity and inflammation in Fas-deficient MRL-lpr mice is accompanied by CNS dysfunction of unknown etiology. Experimental studies revealed infiltration of lymphoid cells into the choroid plexus, reduced neuronal complexity, retarde...

journal_title：Brain research

authors： Ballok DA,Millward JM,Sakic B

更新日期：2003-02-28 00:00:00

abstract：:Theory of Mind (ToM) has been defined as our ability to predict behaviors of others in terms of their underlying intentions. While the developmental trajectory of ToM had been thought to be invariant across cultures, several ToM studies conducted outside the Anglo-American cultural or linguistic milieus have obtained ...

journal_title：Brain research

authors： Kobayashi C,Glover GH,Temple E

更新日期：2007-08-20 00:00:00

abstract：:In the laboratory rat, inhalation (30 s) of high (> 70%) CO2 concentrations resulted in short-term (1-3 min) anesthesia, followed by a prolonged (up to 60 min) mild antinociception. Exposure to 100% CO2 resulted in significant thermal (hot-plate, 52 degrees, and tail-flick) and mechanical (tail-pinch, 886 g force) ant...

journal_title：Brain research

authors： Mischler SA,Alexander M,Battles AH,Raucci JA Jr,Nalwalk JW,Hough LB

更新日期：1994-03-21 00:00:00

abstract：:Behavioral assessments of mouse models of neurodegenerative disorders are useful for investigating the molecular basis of the pathologies of the diseases. Here, we investigated the utility of a water-finding test using a video tracking system as a tool for evaluating cognitive deficits in Alzheimer's disease model mic...

journal_title：Brain research

authors： Kishimoto Y,Higashihara E,Fukuta A,Nagao A,Kirino Y

更新日期：2013-01-23 00:00:00

abstract：:This study aimed to identify the neural correlates of aggression-related attentional selectivity to angry faces in physical aggression. Physical aggression in a non-clinical sample of young men (N = 36) was measured using an aggression questionnaire. Visual attentional bias to angry faces was assessed using a dot-prob...

journal_title：Brain research

authors： Crago RV,Renoult L,Biggart L,Nobes G,Satmarean T,Bowler JO

更新日期：2019-11-15 00:00:00

abstract：:The purpose of this study was to determine if motoneurons in the spinal ventral horn express the muscarinic m2 acetylcholine receptor. Motoneurons were retrogradely labelled in adult rats by intramuscular injection of Fluorogold and examined with confocal microscopy for evidence of immunoreactivity for the receptor. T...

journal_title：Brain research

authors： Welton J,Stewart W,Kerr R,Maxwell DJ

更新日期：1999-01-30 00:00:00

abstract：:Chemotherapy is an effective treatment but difficult to tolerate due to side effects like vomiting. Studies on the etiology of chemotherapy-related emesis have implicated brainstem nuclei and the neurotransmitter substance P, among other substrates. Since rodents do not vomit, other species have been necessary as alte...

journal_title：Brain research

authors： Ray AP,Darmani NA

更新日期：2007-07-02 00:00:00

abstract：:Bone marrow-derived mesenchymal stem cells (BMSCs) are a promising source for cell-based treatment of brain injury, but the therapy of BMSCs is restricted by low cell survival. We examined whether nerve growth factor (NGF) improve BMSCs viability in the brain with Fimbria-Fornix lesion (FF). After transduction of NGF ...

journal_title：Brain research

authors： Leng SL,Fan WG,Qu HG,Xu SC,Zhong WY,Zhang WY,Zeng JQ,Long DH,He HW

更新日期：2009-01-19 00:00:00

abstract：:Conscious male adult rats were concussed by a blow to the occiput with a blunt dart, shot from a spring-loaded pistol. Animals were decapitated within 2 sec, brains quickly removed, several brain regions homogenized in cold buffer and radioreceptor assays carried out. There was a 20% increase in binding of [3H]naloxon...

journal_title：Brain research

authors： West M,LaBella FS,Havlicek V,Parkinson D

更新日期：1981-11-30 00:00:00

abstract：:Excitotoxic effects leading to neuronal cell degeneration are often accompanied by a prolonged increase in the intracellular level of Ca(2+) ions and L-glutamate-induced toxicity is assumed to be mediated via a Ca(2+)-dependent mechanism. Due to their buffering properties, EF-hand Ca(2+)-binding proteins (CaBPs) can a...

journal_title：Brain research

authors： D'Orlando C,Celio MR,Schwaller B

更新日期：2002-08-02 00:00:00

abstract：:Our previous studies have shown that tumor necrosis factor-alpha (TNF-alpha) activates solitary nucleus neurons involved in vago-vagal reflex control of gastric motility. Here, we describe the dual role of TNF-alpha as also modulating neurons in the dorsal motor nucleus of the vagus (DMN) that respond to gastric diste...

journal_title：Brain research

authors： Emch GS,Hermann GE,Rogers RC

更新日期：2002-10-04 00:00:00