Abstract：
:Intracellular and extracellular recordings from CA3 hippocampal neurons in vitro were used to study the ability of several NMDA (N-methyl-D-aspartate) receptor antagonists to suppress epileptiform bursts induced by NMDA and convulsants not thought to act at NMDA receptors. The antagonists, APV (D-2-amino-5-phosphonovalerate), AP-7 (D,L-2-amino-7-phosphonohepatanoate) and CPP (D,L-3[(+/-)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid), blocked the spontaneous and evoked bursts induced by NMDA. CPP, but not APV or AP-7, prevented the development of bursts induced by Mg-free medium. The NMDA antagonists failed to block bursting induced by kainate, 7 mM K+, mast cell degranulating peptide, anoxia or spontaneous bursting. In some cases the NMDA antagonists induced spontaneous bursts or enhanced burst frequency, a proconvulsant effect. It is concluded that activation of NMDA receptors is sufficient but not necessary for burst generation in the CA3 region.
journal_name
Brain Resjournal_title
Brain researchauthors
Neuman R,Cherubini E,Ben-Ari Ydoi
10.1016/0006-8993(88)90642-7subject
Has Abstractpub_date
1988-09-06 00:00:00pages
265-74issue
2eissn
0006-8993issn
1872-6240pii
0006-8993(88)90642-7journal_volume
459pub_type
杂志文章相关文献
BRAIN RESEARCH文献大全abstract：:The functional regulation by dopamine (DA) receptors of serotonin (5-HT) release from the rat substantia nigra (SN) was investigated using in vivo microdialysis. A D1- and D2-receptor-mediated inhibition of nigral 5-HT release was demonstrated in this study. Continuous administration of the D1-receptor agonist CY 2082...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(98)00336-9
更新日期：1998-06-15 00:00:00
abstract：:A major mesolimbic projection towards the hippocampal formation (HF) has been extensively described, but no clear evidence of its dopaminergic content has been demonstrated. In order to evaluate the percentage of dopaminergic (DA) cells of ventral tegmental area (VTA-A10) and adjacent substantia nigra (SN-A9) projecti...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(94)90512-6
更新日期：1994-12-30 00:00:00
abstract：:Endogenous opioids play a role in the regulation of LH-RH neurosecretion throughout the estrous cycle and during the preovulatory LH surge on proestrus. Experimental evidence suggests that opioid influence may be altered with age, and it has been hypothesized that these alterations may contribute to the loss of regula...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91717-7
更新日期：1993-01-22 00:00:00
abstract：:The goal of the present study was to identify the projection from the subdivisions of the amygdaloid nuclear complex to specified subregions of the dorsal raphe (DR) nucleus and to attempt to compare the density of amygdaloid input to the DR with that of inputs from other limbic structures. Use of a retrograde tracer,...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2007.01.081
更新日期：2007-04-27 00:00:00
abstract：:Pituitary adenylate cyclase-activating peptide (PACAP) is a 38-amino-acid polypeptide, first isolated from hypothalamus, which directly stimulates in vitro the production of cAMP as well as the release of several pituitary hormones, such as growth hormone and luteinizing hormone. In vivo, PACAP has been shown to stimu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)01011-1
更新日期：1997-10-31 00:00:00
abstract：:Nerve fibers and terminals immunoreactive for cholecystokinin (CCK) were demonstrated in the nucleus of the solitary tract (NTS) of the rat using light and electron microscopic immunocytochemistry. The following morphological and biochemical evidence suggests that CCK in the NTS seems to be of extrinsic, most probably...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)90408-5
更新日期：1982-12-09 00:00:00
abstract：:These studies examined the microsomal brain metabolism of phencyclidine (PCP) in male and female Sprague-Dawley rats. Several monohydroxylated metabolites of PCP were detected including cis- and trans-1-(1-phenyl-4-hydroxycyclohexyl)piperidine (c-PPC and t-PPC) and 1-(1-phenylcyclohexyl)-4-hydroxypiperidine (PCHP). Th...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(97)00203-5
更新日期：1997-05-09 00:00:00
abstract：:A study was undertaken of the role of the external lateral parabrachial subnucleus (PBNLe) in flavor preferences induced by the intragastric administration of predigested/cephalic food. These preferences were developed using two different learning procedures, concurrent and sequential. In the concurrent procedure, two...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/s0006-8993(02)03032-9
更新日期：2002-09-20 00:00:00
abstract：:Central catecholaminergic nerves have been shown to participate in the integration of cardio-cardiac reflexes induced by coronary artery ligation in the rat. In this study we measured the turnover of dopamine, norepinephrine and epinephrine in microdissected brain regions to identify some of the specific neural loci i...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(82)91010-1
更新日期：1982-03-11 00:00:00
abstract：:Recently, a novel method for detection of DNA synthesis has been developed based on the incorporation of 5-ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, into cellular DNA and the subsequent reaction of EdU with a fluorescent azide in a copper-catalyzed [3+2] cycloaddition ("Click" reaction). In the present stud...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.12.092
更新日期：2010-03-10 00:00:00
abstract：:Brain-derived neurotrophic factor (BDNF) is a family of neurotrophins that plays crucial roles in neural development, survival, maintenance and regeneration both in central and peripheral nervous systems. To examine the effects of BDNF on mastication, jaw movement trajectories and masticatory muscle activities were el...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2004.04.061
更新日期：2004-07-30 00:00:00
abstract：:The roles of spinal N-methyl-d-aspartic acid receptor 2B (NR2B) subunit in central sensitization of chronic visceral pain were investigated. A rat model with irritable bowel syndrome (IBS) was established by colorectal distention (CRD) on post-natal days 8-14. Responses of the external oblique muscle of the abdomen to...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.10.008
更新日期：2014-01-13 00:00:00
abstract：:This study assessed the contribution of K+ conductances to dopamine (DA)-induced modulation of evoked depolarizing synaptic responses (DPSPs) in neostriatal slices obtained from rats. Intracellular recordings of membrane properties and DPSPs evoked by local electrical stimulation were obtained from cells bathed in sta...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(96)00124-2
更新日期：1996-04-29 00:00:00
abstract：:The changes in mean arterial pressure (MAP) and respiratory frequency (RF) in response to microinjection of NMDA or AMPA into the commissural subnucleus of the NTS (comNTS) at the calamus scriptorius level of awake rats were evaluated. Under tribromoethanol anesthesia, the rats received guide-cannulae in direction of ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.09.017
更新日期：2005-11-23 00:00:00
abstract：:Molecular events associated with mnemonic processes and neuronal plasticity are postulated to result in functional changes in synaptic structure. One possible site is the post-synaptic density, where activity-dependent changes modulate signal transduction cascades. In this report, we detail spatial-temporal changes fo...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.02.023
更新日期：2005-04-18 00:00:00
abstract：:During aging, estrogen production and circulating levels of estrogen are markedly decreased in females. Although several differences exist in the process of reproductive aging between women and female rats, the results of many studies suggest that the female rat, especially the middle-aged or aged ovariectomized femal...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2013.11.010
更新日期：2014-01-16 00:00:00
abstract：:The number of adults in the US affected by bipolar disorder, depression, or schizophrenia is approaching 15 million. Despite decades of research, etiologies of these illnesses remain elusive. Theories of aberrant brain morphology, neurotransmission, and signal conduction have provided the heuristic framework for a lar...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2006.05.048
更新日期：2006-08-04 00:00:00
abstract：:The insular cortex (IC) has been reported to modulate the cardiac parasympathetic activity of the baroreflex in unanesthetized rats. However, which neurotransmitters are involved in this modulation is still unclear. In the present study, we evaluated the possible involvement of local IC-noradrenergic neurotransmission...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2009.08.013
更新日期：2009-10-27 00:00:00
abstract：:Golgi examination of neurons of self-stimulation areas of the lateral hypothalamus and substantia nigra-ventral tegmental areas of adult Wistar rats that had experienced self-stimulation for 10 days revealed a significantly higher number of dendritic branching points in the two self-stimulation areas, and also in the ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(90)91079-v
更新日期：1990-09-10 00:00:00
abstract：:Considerable disagreement exists concerning the degree to which sparing and/or recovery of function occurs following CNS damage at birth rather than in adulthood. To study this question, the spinal cord was hemisected in neonatal and adult cats and the motor behavior of the two groups was compared when the neonatal op...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(83)90046-9
更新日期：1983-08-01 00:00:00
abstract：:This research examined the electrophysiological, behavioral and neuroanatomical changes following an injection of kainic acid (KA) which destroyed most of the CA3 pyramidal cells in the hippocampus. For 5 days following the injection of KA, the evoked potential (EP) in the CA1 pyramidal cells produced by stimulation o...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(84)90677-2
更新日期：1984-10-29 00:00:00
abstract：:The purpose of this review is to provide strategies and their rationale which can facilitate scientifically productive investigations into genetic, neuronal, brain functional and clinical aspects of bipolar disorder. The presentation addresses both factors that have impeded and those that have facilitated landmark adv...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2008.05.084
更新日期：2008-10-15 00:00:00
abstract：:The accessibility of macromolecules to the postnatal mammalian central nervous system is a subject of controversy and importance. One of the biologically important macromolecules in neural development, nerve growth factor (NGF), is thought to be unable to cross the blood-brain barrier in postnatal mammals. In this stu...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(93)91775-n
更新日期：1993-05-14 00:00:00
abstract：:Eye and head movements during tracking of a smoothly moving visual target were recorded in trained monkeys. The head movement clearly followed the target, although with considerable variability from cycle to cycle. The eye stayed relatively near the primary position and moved in an apparently irregular fashion; howeve...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(78)91127-7
更新日期：1978-09-15 00:00:00
abstract：:Nucleotide-repeat expansions underlie a heterogeneous group of neurodegenerative and neuromuscular disorders for which there are currently no effective therapies. Recently, it was discovered that such repetitive RNA motifs can support translation initiation in the absence of an AUG start codon across a wide variety of...
journal_title：Brain research
pub_type： 杂志文章,评审
doi：10.1016/j.brainres.2016.04.003
更新日期：2016-09-15 00:00:00
abstract：:Synaptosomes prepared from fresh human cerebral cortex were shown to be morphologically similar to those from other species. On incubation, they took up oxygen at a high and linear rate and accumulated potassium against a concentration gradient. In response to depolarization by raised extracellular K+ or addition of v...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(81)90871-4
更新日期：1981-11-16 00:00:00
abstract：:Hippocampal CA1 pyramidal neurons undergo delayed neurodegeneration after transient forebrain ischemia, and the phenomenon is dependent upon hyperactivation of l-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of glutamate receptors, resulting in aberrant intracellular calcium influx. The GluR2 sub...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/j.brainres.2005.12.123
更新日期：2006-02-23 00:00:00
abstract：:Agents such as 619C89 decrease extracellular glutamate concentrations by a primary action at voltage sensitive sodium channels, but NMDA antagonists also have been shown to decrease extracellular glutamate concentration after ischemia. To address the question as to whether 619C89's effect upon extracellular glutamate ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(95)00868-q
更新日期：1995-11-13 00:00:00
abstract：:Microtubule organization in type I hair cells has been investigated during the synaptogenesis of vestibular receptors in mammals. The different steps in the maturation of the synapse between the hair cell and the nerve chalice were: a slight symmetrical membrane densification; the appearance of synaptic bodies alongsi...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0165-3806(86)90161-6
更新日期：1986-02-01 00:00:00
abstract：UNLABELLED:Discordant changes in brain concentrations of immunoreactive (IR-) adrenocorticotropic hormone (ACTH) or beta-endorphin, peptides derived from pro-opiomelanocortin (POMC), have been reported during the latter part of development and with subsequent aging. These changes were believed to be due to age-related ...
journal_title：Brain research
pub_type： 杂志文章
doi：10.1016/0006-8993(86)90847-4
更新日期：1986-02-05 00:00:00
