Abstract：
:Agents such as 619C89 decrease extracellular glutamate concentrations by a primary action at voltage sensitive sodium channels, but NMDA antagonists also have been shown to decrease extracellular glutamate concentration after ischemia. To address the question as to whether 619C89's effect upon extracellular glutamate concentrations is any different than the effect of the NMDA antagonist dextrorphan, 24 rats were given either optimally neuroprotective doses of these drugs or saline prior to middle cerebral artery occlusion. In caudate, the 619C89-treated, but not dextrorphan-treated rats had less microdialysate glutamate than ischemic controls. In cortex, both 619C89- and dextrorphan-treated groups had significantly decreased glutamate compared with ischemic controls. These results support a specific effect of 619C89 upon glutamate release in caudate but not cortex.
journal_name
Brain Resjournal_title
Brain researchauthors
Chen J,Graham SH,Simon RPdoi
10.1016/0006-8993(95)00868-qsubject
Has Abstractpub_date
1995-11-13 00:00:00pages
121-4issue
1eissn
0006-8993issn
1872-6240pii
0006-8993(95)00868-Qjournal_volume
699pub_type
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